Target Information
Target General Infomation | |||||
---|---|---|---|---|---|
Target ID |
T78464
|
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Former ID |
TTDS00041
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Target Name |
Prostaglandin G/H synthase 2
|
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Gene Name |
PTGS2
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Synonyms |
COX-2; Cyclooxygenase -2; Cyclooxygenase 2; Cyclooxygenase-2; Heme-protein prostaglandin G/H synthase; PGH synthase 2; PGHS-2; PHS II; Prostaglandin H2 synthase 2; Prostaglandin-endoperoxide synthase 2; PTGS2
|
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Target Type |
Successful
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Disease | Asthma [ICD10: J45] | ||||
Arthritis [ICD9: 710-719; ICD10: M00-M25] | |||||
Alzheimer disease [ICD9: 331; ICD10: G30] | |||||
Cancer [ICD9: 140-229; ICD10: C00-C96] | |||||
Chronic pain; Ankylosing spondylitis [ICD9:338.2, 780, 720; ICD10: R52.1-R52.2, G89, M08.1, M45] | |||||
Colon polyps [ICD10: K63.5] | |||||
Dysmenorrhea [ICD9: 625.3; ICD10: N94.4-N94.6] | |||||
Gout [ICD9: 274.00274.1274.8274.9; ICD10: M10] | |||||
Hyperthermia [ICD10: T68] | |||||
Inflammatory bowel disease [ICD9: 555, 556; ICD10: K50, K51] | |||||
Inflammatory disease [ICD9: 140-229, 147, 173, 573.3, 710-719; ICD10: C11, C44, K75.9, M00-M25] | |||||
Inflammation [ICD10: E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89] | |||||
Joint and muscular pain; Arthritis; Dysmenorrhea [ICD10: M00-M25, N94] | |||||
Knee osteoarthritis [ICD9: 715; ICD10: M15-M19, M47] | |||||
Moderate to severe rheumatoid arthritis [ICD10: M05-M06] | |||||
Neuropathic pain [ICD9: 356.0, 356.8; ICD10: G64, G90.0] | |||||
Non-small cell lung cancer; Pancreatic cancer; Rheumatoid arthritis [ICD9:140-199, 140-229, 157, 210-229, 710-719, 714; ICD10: C33-C34, C25, M05-M06] | |||||
Osteoarthritis [ICD9: 715; ICD10: M15-M19, M47] | |||||
Osteoarthritis; Rheumatoid arthritis [ICD9: 714, 715; ICD10: M05-M06, M15-M19, M47] | |||||
Osteoarthritis; Neuropathic pain [ICD9: 338, 356.0, 356.8, 715,780; ICD10: G64, G90.0, M15-M19, M47, R52, G89] | |||||
Pain [ICD9: 338, 356.0, 356.8,780; ICD10: G64, G90.0, R52, G89] | |||||
Pain; Osteoarthritis [ICD9:338, 356.0, 356.8, 780, 715; ICD10: G64, G90.0, R52, G89, M15-M19, M47] | |||||
Pain; Endometriosis [ICD9: 338, 617.0,780; ICD10: N80, R52, G89] | |||||
Rheumatoid arthritis [ICD9: 710-719, 714; ICD10: M05-M06] | |||||
Rheumatoid arthritis; Dysmenorrhea [ICD9:710-719, 714, 625.3; ICD10: M05-M06, N94.4-N94.6] | |||||
Rheumatold arthritis; Pain [ICD9: 338, 714,780; ICD10: M05-M06, R52, G89] | |||||
Rheumatold arthritis; Osteoarthritis [ICD9: 714, 715; ICD10: M05-M06, M15-M19, M47] | |||||
Rheumatold arthritis; Osteoarthritis; Dysmenorrhea [ICD9:714, 715, 625.3; ICD10: M05-M06, M15-M19, M47, N94.4-N94.6] | |||||
Type 2 diabetes [ICD9: 250; ICD10: E11] | |||||
Unspecified [ICD code not available] | |||||
Function |
Converts arachidonate to prostaglandin H2 (PGH2),a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumorangiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis.
|
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BioChemical Class |
Oxidoreductases acting on paired donors
|
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Target Validation |
T78464
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UniProt ID | |||||
EC Number |
EC 1.14.99.1
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Sequence |
MLARALLLCAVLALSHTANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCSTPEFL
TRIKLFLKPTPNTVHYILTHFKGFWNVVNNIPFLRNAIMSYVLTSRSHLIDSPPTYNADY GYKSWEAFSNLSYYTRALPPVPDDCPTPLGVKGKKQLPDSNEIVEKLLLRRKFIPDPQGS NMMFAFFAQHFTHQFFKTDHKRGPAFTNGLGHGVDLNHIYGETLARQRKLRLFKDGKMKY QIIDGEMYPPTVKDTQAEMIYPPQVPEHLRFAVGQEVFGLVPGLMMYATIWLREHNRVCD VLKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNKQFQYQ NRIAAEFNTLYHWHPLLPDTFQIHDQKYNYQQFIYNNSILLEHGITQFVESFTRQIAGRV AGGRNVPPAVQKVSQASIDQSRQMKYQSFNEYRKRFMLKPYESFEELTGEKEMSAELEAL YGDIDAVELYPALLVEKPRPDAIFGETMVEVGAPFSLKGLMGNVICSPAYWKPSTFGGEV GFQIINTASIQSLICNNVKGCPFTSFSVPDPELIKTVTINASSSRSGLDDINPTVLLKER STEL |
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Drugs and Mode of Action | |||||
Drug(s) | Aminosalicylic Acid | Drug Info | Approved | Inflammatory bowel disease | [551871] |
Carprofen | Drug Info | Approved | Pain | [538508], [542149] | |
Celecoxib | Drug Info | Approved | Rheumatold arthritis; Osteoarthritis | [536772], [539915] | |
Diflunisal | Drug Info | Approved | Pain | [538256], [542171] | |
Etodolac | Drug Info | Approved | Pain | [538288], [542196] | |
Etoricoxib | Drug Info | Approved | Rheumatold arthritis; Osteoarthritis | [536058], [539919] | |
FENBUFEN | Drug Info | Approved | Arthritis | [551871] | |
Flufenamic Acid | Drug Info | Approved | Dysmenorrhea | [539575], [551871] | |
Flurbiprofen | Drug Info | Approved | Rheumatoid arthritis | [467529], [538273] | |
Ibuprofen | Drug Info | Approved | Pain | [536772], [539773] | |
Indomethacin | Drug Info | Approved | Moderate to severe rheumatoid arthritis | [551871] | |
Ketoprofen | Drug Info | Approved | Rheumatold arthritis; Pain | [468024], [538253] | |
Lumiracoxib | Drug Info | Approved | Knee osteoarthritis | [536058], [539920] | |
Meclofenamate Sodium | Drug Info | Approved | Joint and muscular pain; Arthritis; Dysmenorrhea | [551871] | |
Mefenamic acid | Drug Info | Approved | Rheumatold arthritis; Osteoarthritis; Dysmenorrhea | [538469], [539671], [551871] | |
Meloxicam | Drug Info | Approved | Arthritis | [524822], [542235], [551871] | |
Nabumetone | Drug Info | Approved | Pain | [523116], [542262] | |
Naproxen | Drug Info | Approved | Osteoarthritis; Rheumatoid arthritis | [551871] | |
Niflumic Acid | Drug Info | Approved | Rheumatoid arthritis; Dysmenorrhea | [539567], [550701], [551871] | |
Phenylbutazone | Drug Info | Approved | Chronic pain; Ankylosing spondylitis | [536447], [542290], [551871] | |
Rofecoxib | Drug Info | Approved | Osteoarthritis | [536772], [539916] | |
Tenoxicam | Drug Info | Approved | Rheumatold arthritis; Osteoarthritis | [527467], [527583], [550768] | |
Tiaprofenic acid | Drug Info | Approved | Pain; Osteoarthritis | [550690], [551871] | |
Tolmetin | Drug Info | Approved | Rheumatold arthritis; Osteoarthritis | [538251], [542334], [551871] | |
Valdecoxib | Drug Info | Approved | Osteoarthritis; Rheumatoid arthritis | [536232], [539917] | |
IMRECOXIB | Drug Info | Phase 4 | Discovery agent | [524526] | |
Celecoxib | Drug Info | Phase 3 | Pain | [536772], [539915] | |
CG-100649 | Drug Info | Phase 3 | Arthritis | [524183], [543067] | |
Curcumin | Drug Info | Phase 3 | Cancer | [532348], [542031] | |
diclofenac sodium patch | Drug Info | Phase 3 | Unspecified | [1559699] | |
DOCOSAHEXAENOIC ACID | Drug Info | Phase 3 | Alzheimer disease | [538634] | |
Ketoprofen | Drug Info | Phase 3 | Pain | [526212], [526261] | |
ketoprofen patch | Drug Info | Phase 3 | Unspecified | [526212], [526261] | |
ThermoProfen | Drug Info | Phase 3 | Pain | [522046] | |
Darbufelone | Drug Info | Phase 2/3 | Asthma | [532278] | |
CIMICOXIB | Drug Info | Phase 2 | Pain | [522081] | |
FK-3311 | Drug Info | Phase 2 | Rheumatoid arthritis | [528936] | |
Naproxen | Drug Info | Phase 2 | Pain | [468283], [523066] | |
SC-75416 | Drug Info | Phase 2 | Pain | [549824] | |
RWJ-67657 | Drug Info | Phase 1 | Arthritis | [525614] | |
INDOPROFEN | Drug Info | Withdrawn from market | Gout | [551871] | |
Nimesulide | Drug Info | Withdrawn from market | Discovery agent | [523284], [542424] | |
GW-406381 | Drug Info | Discontinued in Phase 3 | Osteoarthritis; Neuropathic pain | [536374] | |
PRINOMIDE TROMETHAMINE | Drug Info | Discontinued in Phase 3 | Inflammation | [544513] | |
Apricoxib | Drug Info | Discontinued in Phase 2 | Non-small cell lung cancer; Pancreatic cancer; Rheumatoid arthritis | [548493] | |
CRx-401 | Drug Info | Discontinued in Phase 2 | Type 2 diabetes | [547745] | |
GSK-644784 | Drug Info | Discontinued in Phase 2 | Neuropathic pain | [536374] | |
R-KETOPROFEN | Drug Info | Discontinued in Phase 2 | Discovery agent | [546255] | |
RQ-00317076 | Drug Info | Discontinued in Phase 2 | Pain | [549268] | |
S-2474 | Drug Info | Discontinued in Phase 2 | Rheumatoid arthritis | [546762] | |
TEBUFELONE | Drug Info | Discontinued in Phase 2 | Pain | [545171] | |
Tilmacoxib | Drug Info | Discontinued in Phase 2 | Colon polyps | [546604] | |
DUP 697 | Drug Info | Discontinued in Phase 1 | Pain | [544772] | |
E-6087 | Drug Info | Discontinued in Phase 1 | Pain | [547425] | |
GR-253035 | Drug Info | Discontinued in Phase 1 | Alzheimer disease | [546666] | |
SC-57666 | Drug Info | Discontinued in Phase 1 | Rheumatoid arthritis | [546187] | |
ATLIPROFEN METHYL ESTER | Drug Info | Terminated | Inflammation | [544774] | |
Flosulide | Drug Info | Terminated | Pain | [544771] | |
FR-123826 | Drug Info | Terminated | Rheumatoid arthritis | [546414] | |
L-745337 | Drug Info | Terminated | Asthma | [545938] | |
L-768277 | Drug Info | Terminated | Hyperthermia | [546606] | |
NMI-150 | Drug Info | Terminated | Pain | [547873] | |
NS398 | Drug Info | Terminated | Pain; Endometriosis | [545169] | |
ON-09300 | Drug Info | Terminated | Cancer | [547989] | |
RPR 200765A | Drug Info | Terminated | Rheumatoid arthritis | [547101] | |
RWJ-63556 | Drug Info | Terminated | Arthritis | [534446] | |
S-33516 | Drug Info | Terminated | Arthritis | [547095] | |
SB 203580 | Drug Info | Terminated | Discovery agent | [540732], [546259] | |
SC-236 | Drug Info | Terminated | Cancer | [547069] | |
SC-58125 | Drug Info | Terminated | Discovery agent | [545991] | |
SC-58451 | Drug Info | Terminated | Discovery agent | [546186] | |
Inhibitor | (11H-Dibenzo[b,e][1,4]dioxepin-2-yl)-acetic acid | Drug Info | [533456] | ||
(11H-Dibenzo[b,e][1,4]dioxepin-7-yl)-acetic acid | Drug Info | [533456] | |||
(11H-Dibenzo[b,e][1,4]dioxepin-8-yl)-acetic acid | Drug Info | [533456] | |||
(E)-2-(4-(methylsulfonyl)styryl)furan | Drug Info | [531229] | |||
(E)-2-(4-(methylsulfonyl)styryl)thiophene | Drug Info | [531229] | |||
(E)-3-(4-(methylsulfonyl)styryl)thiophene | Drug Info | [531229] | |||
(E)-4-(2-(furan-2-yl)vinyl)benzenesulfonamide | Drug Info | [531229] | |||
(E)-4-(2-(thiophen-2-yl)vinyl)benzenesulfonamide | Drug Info | [531229] | |||
(E)-4-(2-(thiophen-3-yl)vinyl)benzenesulfonamide | Drug Info | [531229] | |||
(R)-2-(4-Isobutyl-phenyl)-N-phenyl-propionamide | Drug Info | [527602] | |||
(S)-FLURBIPROFEN | Drug Info | [527602] | |||
(Z)-2'-des-methyl sulindac sulfide | Drug Info | [530116] | |||
1,2-dihydro-3-(2,3,4-trimethoxyphenyl)naphthalene | Drug Info | [528934] | |||
1,3-bis(nitrooxy)propan-2-yl 2-acetoxybenzoate | Drug Info | [530105] | |||
1-(2-hydroxyphenyl)-3-p-tolylprop-2-en-1-one | Drug Info | [529976] | |||
1-(4-(methylsulfonyl)phenyl)-1H-indole | Drug Info | [531135] | |||
1-(4-(methylsulfonyl)phenyl)-1H-pyrrole | Drug Info | [531135] | |||
1-(4-(methylsulfonyl)phenyl)-3-p-tolylurea | Drug Info | [529273] | |||
1-(4-(methylsulfonyl)phenyl)-3-phenylurea | Drug Info | [529273] | |||
1-(4-aminosulfonylphenyl)-2-(2-pyridyl)acetylene | Drug Info | [529156] | |||
2'-hydroxy-3,4,5-trimethoxychalcone | Drug Info | [529976] | |||
2'-Hydroxychalcone | Drug Info | [529976] | |||
2,3-dimethoxy-2'-hydroxychalcone | Drug Info | [529976] | |||
2,4'-Dimethoxy-5,3'-di-(2-propenyl)-biphenyl | Drug Info | [530176] | |||
2,4'-Dimethoxy-5,3'-dipropyl-biphenyl | Drug Info | [530176] | |||
2,4-dimethoxy-2'-hydroxychalcone | Drug Info | [529976] | |||
2,6-dihydroxy-1,7-dimethoxyxanthone | Drug Info | [527828] | |||
2-(2,3,4-trimethoxyphenyl)-1H-indene | Drug Info | [528934] | |||
2-(2-(2,6-dimethylphenylamino)phenyl)acetic acid | Drug Info | [528789] | |||
2-(3-Phenyl-propyl)-1,2-dihydro-indazol-3-one | Drug Info | [529474] | |||
2-(4-(methylsulfonyl)phenyl)-3-phenylquinoline | Drug Info | [530629] | |||
2-(4-(methylsulfonyl)phenyl)pyridine | Drug Info | [531135] | |||
2-(N-(2-Ffuorophenyl)pyrrol-3-yl) acetic acid | Drug Info | [528854] | |||
2-(N-(2-fluorophenyl)pyrrol-2-yl) acetic acid | Drug Info | [528854] | |||
2-(p-Methylsulfonylbenzoyl)furan | Drug Info | [531135] | |||
2-Benzyl-1,2-dihydro-indazol-3-one | Drug Info | [529474] | |||
2-Furan-2-ylmethyl-1,2-dihydro-indazol-3-one | Drug Info | [529474] | |||
2-Methyl-1,2-dihydro-indazol-3-one | Drug Info | [529474] | |||
2-Naphthalen-2-ylmethyl-1,2-dihydro-indazol-3-one | Drug Info | [529474] | |||
2-Phenethyl-1,2-dihydro-indazol-3-one | Drug Info | [529474] | |||
2-Phenyl-1,2-dihydro-indazol-3-one | Drug Info | [529474] | |||
3 beta-O-acetyloleanolic acid | Drug Info | [528272] | |||
3,4-dibenzyloxy-2'-hydroxychalcone | Drug Info | [529976] | |||
3,4-dihydroxyxanthone | Drug Info | [527828] | |||
3-(4-Methanesulfonyl-phenyl)-1-phenyl-propynone | Drug Info | [527727] | |||
3-benzyloxy-4-methoxy-2'-hydroxychalcone | Drug Info | [529976] | |||
3-Bromo-2'-hydroxy-4-methoxychalcone | Drug Info | [529976] | |||
4,5-Bis(4-chlorophenyl)-1,2-selenazole | Drug Info | [529127] | |||
4,5-Bis(4-chlorophenyl)isothiazole | Drug Info | [529881] | |||
4,5-Bis(4-methoxyphenyl)-1,2-selenazole | Drug Info | [529127] | |||
4,5-Bis(4-methoxyphenyl)-3H-1,2-dithiol-3-one | Drug Info | [529881] | |||
4,5-Bis(4-methoxyphenyl)isothiazole | Drug Info | [529881] | |||
4-((4-methoxyphenyl)diazenyl)benzenesulfonamide | Drug Info | [528283] | |||
4-(3-hydroxy-benzylideneamino)-benzenesulfonamide | Drug Info | [529203] | |||
4-(3-methoxy-benzylideneamino)-benzenesulfonamide | Drug Info | [529203] | |||
4-(3-nitro-benzylideneamino)-benzenesulfonamide | Drug Info | [529203] | |||
4-(4-Chlorophenyl)-5-p-tolyl-1,2-selenazole | Drug Info | [529127] | |||
4-(4-fluoro-benzylideneamino)-benzenesulfonamide | Drug Info | [529203] | |||
4-(4-fluoro-phenyliminomethyl)-benzenesulfonamide | Drug Info | [529203] | |||
4-(4-hydroxy-benzylideneamino)-benzenesulfonamide | Drug Info | [529203] | |||
4-(4-methoxy-benzylideneamino)-benzenesulfonamide | Drug Info | [529203] | |||
4-(4-methyl-benzylideneamino)-benzenesulfonamide | Drug Info | [529203] | |||
4-(4-methyl-phenyliminomethyl)-benzenesulfonamide | Drug Info | [529203] | |||
4-(4-nitro-benzylideneamino)-benzenesulfonamide | Drug Info | [529203] | |||
4-(benzylideneamino)benzenesulfonamide | Drug Info | [529203] | |||
4-amino-N-(4-chlorophenyl)benzenesulfonamide | Drug Info | [528508] | |||
4-amino-N-(4-iodophenyl)benzenesulfonamide | Drug Info | [528508] | |||
4-benzyloxy-2'-hydroxychalcone | Drug Info | [529976] | |||
4-fluoro-N-(4-(methylsulfonyl)phenyl)aniline | Drug Info | [531135] | |||
4-phenyliminomethyl-benzenesulfonamide | Drug Info | [529203] | |||
5,3'-Dipropyl-biphenyl-2,4'-diol | Drug Info | [530176] | |||
5-(2-Imidazol-1-yl-ethyl)-7,8-dihydro-quinoline | Drug Info | [525760] | |||
5-(4-Chlorophenyl)-4-p-tolyl-1,2-selenazole | Drug Info | [529127] | |||
5-(4-Methoxyphenyl)-4-p-tolyl-1,2-selenazole | Drug Info | [529127] | |||
5-Ethyl-3,4-diphenyl-isoxazole | Drug Info | [527215] | |||
5-methoxy-2-(4-(methylsulfonyl)phenyl)-1H-indole | Drug Info | [530236] | |||
5-Methyl-3,4-diphenyl-isoxazole | Drug Info | [527215] | |||
5-Phenyl-pentanoic acid benzyl-hydroxy-amide | Drug Info | [532882] | |||
5-thia-8,11,14,17-eicosatetraenoic acid | Drug Info | [526089] | |||
6,7'-oxybis(2-phenyl-4H-chromen-4-one) | Drug Info | [529827] | |||
8alpha,19-dihydroxylabd-13 E-en-15-oic acid | Drug Info | [529467] | |||
Apricoxib | Drug Info | [530463] | |||
B-Octylglucoside | Drug Info | [551393] | |||
Bimetopyrole | Drug Info | [536606] | |||
Carprofen | Drug Info | [536327] | |||
Celecoxib | Drug Info | [536549], [549843], [549974] | |||
CG-100649 | Drug Info | [532911] | |||
CLEMATOMANDSHURICA SAPONIN A | Drug Info | [528538] | |||
CLEMATOMANDSHURICA SAPONIN B | Drug Info | [528538] | |||
COX-2 inhibitors | Drug Info | [543413] | |||
CR-4174 | Drug Info | [543413] | |||
CRx-401 | Drug Info | [522072] | |||
Curcumin | Drug Info | [527489] | |||
CX-9051 | Drug Info | [543413] | |||
DFU | Drug Info | [535003] | |||
Diflunisal | Drug Info | [535160] | |||
DOCOSAHEXAENOIC ACID | Drug Info | [526089] | |||
DUP 697 | Drug Info | [536606] | |||
E-6087 | Drug Info | [527028], [551871] | |||
Etodolac | Drug Info | [535206], [536446] | |||
Etoricoxib | Drug Info | [537000], [537380] | |||
FENBUFEN | Drug Info | [530153] | |||
Firocoxib | Drug Info | [525574] | |||
Flufenamic Acid | Drug Info | [551392] | |||
Fluoro loxoprofen | Drug Info | [531221] | |||
FR-123826 | Drug Info | [546415] | |||
Furan-3-yl(4-(methylsulfonyl)phenyl)methanone | Drug Info | [531135] | |||
GSK-644784 | Drug Info | [536374] | |||
GW-406381 | Drug Info | [536374] | |||
GW-637185X | Drug Info | [530203] | |||
Heme | Drug Info | [551374] | |||
HONOKIOL | Drug Info | [530176] | |||
Ibuprofen | Drug Info | [535585], [537246], [538149] | |||
IMRECOXIB | Drug Info | [530021] | |||
INDOPROFEN | Drug Info | [527602] | |||
Ketoprofen | Drug Info | [536440] | |||
L-748780 | Drug Info | [551313] | |||
L-761000 | Drug Info | [551313] | |||
LINOLENIC ACID | Drug Info | [526089] | |||
LM-4108 | Drug Info | [530627] | |||
Lumiracoxib | Drug Info | [537120] | |||
Mefenamic acid | Drug Info | [538129] | |||
Meloxicam | Drug Info | [534421] | |||
METHYLHONOKIOL | Drug Info | [530176] | |||
Microxine | Drug Info | [537922] | |||
N-(1H-indazol-5-yl)acetamide | Drug Info | [529838] | |||
N-(3-(phenylthio)pyridin-4-yl)methanesulfonamide | Drug Info | [530415] | |||
N-(3-phenoxy-4-pyridinyl)ethanesulfonamide | Drug Info | [527352] | |||
N-(3-phenylamino-4-pyridinyl)methanesulfonamide | Drug Info | [530415] | |||
Nabumetone | Drug Info | [526187] | |||
Naproxen | Drug Info | [525885] | |||
Naproxene | Drug Info | [536772] | |||
Nectamazin C | Drug Info | [530493] | |||
NEOLIGNAN 9-NOR-7,8-DEHYDRO-ISOLICARIN B | Drug Info | [530493] | |||
Niflumic Acid | Drug Info | [536416] | |||
Nimesulide | Drug Info | [551378] | |||
NMI-150 | Drug Info | [544345] | |||
NS398 | Drug Info | [536772] | |||
NSAIDs | Drug Info | [535528] | |||
NSC-27236 | Drug Info | [528283] | |||
OCOPHYLLALS A | Drug Info | [530493] | |||
OCOPHYLLALS B | Drug Info | [530493] | |||
Oxametacin | Drug Info | [529146] | |||
PAC-10649 | Drug Info | [549744] | |||
PHENIDONE | Drug Info | [529474] | |||
Phenylbutazone | Drug Info | [536097] | |||
Prifelone | Drug Info | [527799] | |||
Primary alcohol metabolite of celecoxib | Drug Info | [529754] | |||
PRINOMIDE TROMETHAMINE | Drug Info | [526385], [551871] | |||
Prostaglandin G2 | Drug Info | [551374] | |||
R-KETOPROFEN | Drug Info | [527602] | |||
Resveratrol Potassium3-Sulfate | Drug Info | [530955] | |||
Resveratrol Potassium4,-Sulfate | Drug Info | [530955] | |||
Rofecoxib | Drug Info | [535528], [535660], [535785], [535836], [536549] | |||
RPR 200765A | Drug Info | [535126] | |||
RQ-00317076 | Drug Info | [551562] | |||
RWJ-67657 | Drug Info | [535386] | |||
S-2474 | Drug Info | [526157] | |||
S-33516 | Drug Info | [549752] | |||
SB 202190 | Drug Info | [535059] | |||
SB 203580 | Drug Info | [535005] | |||
SB 239063 | Drug Info | [535290] | |||
SC-236 | Drug Info | [527033] | |||
SC-558 | Drug Info | [530753] | |||
SC-57666 | Drug Info | [534599] | |||
SC-58125 | Drug Info | [530207] | |||
SC-58451 | Drug Info | [551307] | |||
SC-75416 | Drug Info | [529055] | |||
Silicon-modified indomethacin | Drug Info | [543413] | |||
TEBUFELONE | Drug Info | [534599] | |||
TENOSAL | Drug Info | [550917], [551871] | |||
Tenoxicam | Drug Info | [536034], [536149] | |||
ThermoProfen | Drug Info | [530772] | |||
THIOCTIC ACID | Drug Info | [529127] | |||
Tiaprofenic acid | Drug Info | [537672] | |||
Tilmacoxib | Drug Info | [526297] | |||
Tolmetin | Drug Info | [537246] | |||
Topical etoricoxib | Drug Info | [543413] | |||
Valdecoxib | Drug Info | [536232] | |||
WOGONIN | Drug Info | [529976] | |||
XGP-110 | Drug Info | [543413] | |||
Modulator | Aminosalicylic Acid | Drug Info | [556264] | ||
ATLIPROFEN METHYL ESTER | Drug Info | [556264] | |||
CIMICOXIB | Drug Info | ||||
Darbufelone | Drug Info | [532278] | |||
diclofenac sodium patch | Drug Info | ||||
FK-3311 | Drug Info | [528936] | |||
Flosulide | Drug Info | [525636] | |||
Flurbiprofen | Drug Info | ||||
GR-253035 | Drug Info | [544016] | |||
Indomethacin | Drug Info | [556264] | |||
ketoprofen patch | Drug Info | [526212], [526261] | |||
L-745337 | Drug Info | ||||
L-768277 | Drug Info | [551650] | |||
Meclofenamate Sodium | Drug Info | ||||
Nitroflurbiprofen | Drug Info | ||||
ON-09300 | Drug Info | [556264] | |||
RWJ-63556 | Drug Info | [534446] | |||
Regulator (upregulator) | C-myb | Drug Info | [534981] | ||
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM) | |||||
Pathways | |||||
BioCyc Pathway | Aspirin-triggered lipoxin biosynthesis | ||||
Aspirin triggered resolvin D biosynthesis | |||||
C20 prostanoid biosynthesis | |||||
Aspirin triggered resolvin E biosynthesis | |||||
KEGG Pathway | Arachidonic acid metabolism | ||||
Metabolic pathways | |||||
NF-kappa B signaling pathway | |||||
VEGF signaling pathway | |||||
TNF signaling pathway | |||||
Retrograde endocannabinoid signaling | |||||
Serotonergic synapse | |||||
Ovarian steroidogenesis | |||||
Oxytocin signaling pathway | |||||
Regulation of lipolysis in adipocytes | |||||
Leishmaniasis | |||||
Pathways in cancer | |||||
Chemical carcinogenesis | |||||
MicroRNAs in cancer | |||||
Small cell lung cancer | |||||
NetPath Pathway | IL1 Signaling Pathway | ||||
TSH Signaling Pathway | |||||
IL4 Signaling Pathway | |||||
TGF_beta_Receptor Signaling Pathway | |||||
IL5 Signaling Pathway | |||||
PANTHER Pathway | Endothelin signaling pathway | ||||
Inflammation mediated by chemokine and cytokine signaling pathway | |||||
Toll receptor signaling pathway | |||||
CCKR signaling map ST | |||||
Pathway Interaction Database | Calcineurin-regulated NFAT-dependent transcription in lymphocytes | ||||
S1P1 pathway | |||||
C-MYB transcription factor network | |||||
Signaling mediated by p38-alpha and p38-beta | |||||
Calcium signaling in the CD4+ TCR pathway | |||||
PathWhiz Pathway | Arachidonic Acid Metabolism | ||||
WikiPathways | Prostaglandin Synthesis and Regulation | ||||
Arachidonic acid metabolism | |||||
Aryl Hydrocarbon Receptor | |||||
Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis | |||||
Spinal Cord Injury | |||||
Integrated Pancreatic Cancer Pathway | |||||
Eicosanoid Synthesis | |||||
Selenium Micronutrient Network | |||||
References | |||||
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Ref 546606 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009152) | ||||
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Ref 546762 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010176) | ||||
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Ref 547101 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800013076) | ||||
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Ref 547745 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018957) | ||||
Ref 547873 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800020060) | ||||
Ref 547989 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800020980) | ||||
Ref 548493 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800026002) | ||||
Ref 549268 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800034373) | ||||
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Ref 529055 | Modeling and simulation to support dose selection and clinical development of SC-75416, a selective COX-2 inhibitor for the treatment of acute and chronic pain. Clin Pharmacol Ther. 2008 Jun;83(6):857-66. Epub 2007 Sep 19. | ||||
Ref 529127 | Eur J Med Chem. 2008 Jun;43(6):1152-9. Epub 2007 Sep 22.Investigations concerning the COX/5-LOX inhibiting and hydroxyl radical scavenging potencies of novel 4,5-diaryl isoselenazoles. | ||||
Ref 529146 | J Med Chem. 2007 Dec 13;50(25):6367-82. Epub 2007 Nov 10.Structure-based design, synthesis, and biological evaluation of indomethacin derivatives as cyclooxygenase-2 inhibiting nitric oxide donors. | ||||
Ref 529156 | Bioorg Med Chem. 2008 Feb 15;16(4):1948-56. Epub 2007 Nov 5.Synthesis and cyclooxygenase inhibitory activities of linear 1-(methanesulfonylphenyl or benzenesulfonamido)-2-(pyridyl)acetylene regioisomers. | ||||
Ref 529203 | Bioorg Med Chem. 2008 Mar 1;16(5):2697-706. Epub 2007 Nov 17.Selective COX-2 inhibitors. Part 2: synthesis and biological evaluation of 4-benzylideneamino- and 4-phenyliminomethyl-benzenesulfonamides. | ||||
Ref 529273 | Bioorg Med Chem Lett. 2008 Feb 15;18(4):1336-9. Epub 2008 Jan 11.Design and synthesis of 1,3-diarylurea derivatives as selective cyclooxygenase (COX-2) inhibitors. | ||||
Ref 529467 | J Nat Prod. 2008 Jun;71(6):1070-3. Epub 2008 May 13.Cyclooxygenase (COX)-1 and -2 inhibitory labdane diterpenes from Crassocephalum mannii. | ||||
Ref 529474 | J Med Chem. 1991 Mar;34(3):1028-36.Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity. | ||||
Ref 529754 | Bioorg Med Chem. 2008 Nov 15;16(22):9694-8. Epub 2008 Oct 5.Diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of 5-(4-hydroxymethylphenyl)-1-(4-aminosulfonylphenyl)-3-trifluoromethyl-1H-pyrazole and its methanesulfonyl analog: synthesis, biological evaluation and nitric oxide release studies. | ||||
Ref 529827 | Bioorg Med Chem Lett. 2009 Jan 1;19(1):74-6. Epub 2008 Nov 12.Synthesis of biflavones having a 6-O-7'' linkage and effects on cyclooxygenase-2 and inducible nitric oxide synthase. | ||||
Ref 529838 | J Med Chem. 2008 Dec 25;51(24):7800-5.New analgesics synthetically derived from the paracetamol metabolite N-(4-hydroxyphenyl)-(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-enamide. | ||||
Ref 529881 | Bioorg Med Chem. 2009 Jan 15;17(2):558-68. Epub 2008 Dec 6.Diaryl-dithiolanes and -isothiazoles: COX-1/COX-2 and 5-LOX-inhibitory, *OH scavenging and anti-adhesive activities. | ||||
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