Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D08LFZ
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| Former ID |
DAP000152
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| Drug Name |
Diflunisal
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| Synonyms |
Adomal; Algobid; Citidol; Difludol; Diflunisalum; Dolisal; Dolobid; Dolobil; Dolobis; Dolocid; Flovacil; Fluniget; Fluodonil; Flustar; Noaldol; Reuflos; Unisal; Apotex Brand of Diflunisal; Cahill May Roberts Brand of Diflunisal; Diflunisal Novopharm Brand; Frosst SA Brand of Diflunisal; Merck Brand of Diflunisal; Novopharm Brand of Diflunisal; Nu Pharm Brand of Diflunisal; MK 647; MK647; Apo-Diflunisal; Diflunisalum [INN-Latin]; Dolobid (TN); MK-647; Merck Sharp & Dohme Brand of Diflunisal; Novo-Diflunisal; Nu-Diflunisal; Nu-Pharm Brand of Diflunisal; Diflunisal (JAN/USP/INN); Diflunisal [USAN:INN:BAN:JAN]; 2',4'-Difluoro-4-hydroxy-(1,1'-biphenyl)-3-carboxylic acid; 2',4'-Difluoro-4-hydroxy-3-biphenylcarboxylic acid; 2',4'-difluoro-4-hydroxybiphenyl-3-carboxylic acid; 2-(Hydroxy)-5-(2,4-difluorophenyl)benzoic acid; 5-(2,4-DIFLUOROPHENYL)-2-HYDROXY-BENZOIC ACID; 5-(2,4-Difluorophenyl)salicylic acid; 5-(2,4-difluorophenyl)-2-hydroxybenzoic acid; 5-[2,4-Difluorophenyl]salicylic acid
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| Drug Type |
Small molecular drug
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| Therapeutic Class |
Analgesics
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| Company |
Merck & Co
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| Structure |
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Download2D MOL |
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| Formula |
C13H8F2O3
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| InChI |
InChI=1S/C13H8F2O3/c14-8-2-3-9(11(15)6-8)7-1-4-12(16)10(5-7)13(17)18/h1-6,16H,(H,17,18)
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| InChIKey |
HUPFGZXOMWLGNK-UHFFFAOYSA-N
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| CAS Number |
CAS 22494-42-4
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| PubChem Compound ID | |||||
| PubChem Substance ID |
4832, 855794, 3220269, 5635336, 7847198, 7885083, 7979080, 8027938, 8149302, 8151945, 10321268, 10514228, 11112675, 11336113, 11361352, 11363856, 11366418, 11368980, 11371523, 11374224, 11377142, 11462324, 11466067, 11467187, 11484899, 11485794, 11488828, 11490208, 11492328, 11494776, 12013398, 15221177, 24893742, 26611703, 26679788, 26697369, 26746997, 26746998, 29222205, 46507807, 47216844, 47365272, 47440348, 47589066, 47736568, 47810827, 47959840, 48415892, 49698694, 49738138
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| ChEBI ID |
ChEBI:39669
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| SuperDrug ATC ID |
N02BA11
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| SuperDrug CAS ID |
cas=022494424
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| Target and Pathway | |||||
| Target(s) | Prostaglandin G/H synthase 2 | Target Info | Inhibitor | [535160] | |
| KEGG Pathway | Arachidonic acid metabolism | ||||
| Metabolic pathways | |||||
| NF-kappa B signaling pathway | |||||
| VEGF signaling pathway | |||||
| TNF signaling pathway | |||||
| Retrograde endocannabinoid signaling | |||||
| Serotonergic synapse | |||||
| Ovarian steroidogenesis | |||||
| Oxytocin signaling pathway | |||||
| Regulation of lipolysis in adipocytes | |||||
| Leishmaniasis | |||||
| Pathways in cancer | |||||
| Chemical carcinogenesis | |||||
| MicroRNAs in cancer | |||||
| Small cell lung cancer | |||||
| PathWhiz Pathway | Arachidonic Acid Metabolism | ||||
| References | |||||
| Ref 538256 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 073562. | ||||
| Ref 542171 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7162). | ||||
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