Target Information

Target General Infomation
Target ID
T78464
Former ID
TTDS00041
Target Name
Prostaglandin G/H synthase 2
Gene Name
PTGS2
Synonyms
COX-2; Cyclooxygenase -2; Cyclooxygenase 2; Cyclooxygenase-2; Heme-protein prostaglandin G/H synthase; PGH synthase 2; PGHS-2; PHS II; Prostaglandin H2 synthase 2; Prostaglandin-endoperoxide synthase 2; PTGS2
Target Type
Successful
Disease Alzheimer disease [ICD9: 331; ICD10: G30]
Asthma [ICD10: J45]
Arthritis [ICD9: 710-719; ICD10: M00-M25]
Chronic pain; Ankylosing spondylitis [ICD9:338.2, 780, 720; ICD10: R52.1-R52.2, G89, M08.1, M45]
Colon polyps [ICD10: K63.5]
Cancer [ICD9: 140-229; ICD10: C00-C96]
Dysmenorrhea [ICD9: 625.3; ICD10: N94.4-N94.6]
Gout [ICD9: 274.00274.1274.8274.9; ICD10: M10]
Hyperthermia [ICD10: T68]
Inflammation [ICD10: E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89]
Inflammatory bowel disease [ICD9: 555, 556; ICD10: K50, K51]
Inflammatory disease [ICD9: 140-229, 147, 173, 573.3, 710-719; ICD10: C11, C44, K75.9, M00-M25]
Joint and muscular pain; Arthritis; Dysmenorrhea [ICD10: M00-M25, N94]
Knee osteoarthritis [ICD9: 715; ICD10: M15-M19, M47]
Moderate to severe rheumatoid arthritis [ICD10: M05-M06]
Neuropathic pain [ICD9: 356.0, 356.8; ICD10: G64, G90.0]
Non-small cell lung cancer; Pancreatic cancer; Rheumatoid arthritis [ICD9:140-199, 140-229, 157, 210-229, 710-719, 714; ICD10: C33-C34, C25, M05-M06]
Osteoarthritis; Neuropathic pain [ICD9: 338, 356.0, 356.8, 715,780; ICD10: G64, G90.0, M15-M19, M47, R52, G89]
Osteoarthritis [ICD9: 715; ICD10: M15-M19, M47]
Osteoarthritis; Rheumatoid arthritis [ICD9: 714, 715; ICD10: M05-M06, M15-M19, M47]
Pain; Osteoarthritis [ICD9:338, 356.0, 356.8, 780, 715; ICD10: G64, G90.0, R52, G89, M15-M19, M47]
Pain; Endometriosis [ICD9: 338, 617.0,780; ICD10: N80, R52, G89]
Pain [ICD9: 338, 356.0, 356.8,780; ICD10: G64, G90.0, R52, G89]
Rheumatold arthritis; Pain [ICD9: 338, 714,780; ICD10: M05-M06, R52, G89]
Rheumatold arthritis; Osteoarthritis [ICD9: 714, 715; ICD10: M05-M06, M15-M19, M47]
Rheumatold arthritis; Osteoarthritis; Dysmenorrhea [ICD9:714, 715, 625.3; ICD10: M05-M06, M15-M19, M47, N94.4-N94.6]
Rheumatoid arthritis [ICD9: 710-719, 714; ICD10: M05-M06]
Rheumatoid arthritis; Dysmenorrhea [ICD9:710-719, 714, 625.3; ICD10: M05-M06, N94.4-N94.6]
Type 2 diabetes [ICD9: 250; ICD10: E11]
Unspecified [ICD code not available]
Function
Converts arachidonate to prostaglandin H2 (PGH2),a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumorangiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis.
BioChemical Class
Oxidoreductases acting on paired donors
Target Validation
T78464
UniProt ID
P35354
EC Number
EC 1.14.99.1
Sequence
MLARALLLCAVLALSHTANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCSTPEFL
TRIKLFLKPTPNTVHYILTHFKGFWNVVNNIPFLRNAIMSYVLTSRSHLIDSPPTYNADY
GYKSWEAFSNLSYYTRALPPVPDDCPTPLGVKGKKQLPDSNEIVEKLLLRRKFIPDPQGS
NMMFAFFAQHFTHQFFKTDHKRGPAFTNGLGHGVDLNHIYGETLARQRKLRLFKDGKMKY
QIIDGEMYPPTVKDTQAEMIYPPQVPEHLRFAVGQEVFGLVPGLMMYATIWLREHNRVCD
VLKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNKQFQYQ
NRIAAEFNTLYHWHPLLPDTFQIHDQKYNYQQFIYNNSILLEHGITQFVESFTRQIAGRV
AGGRNVPPAVQKVSQASIDQSRQMKYQSFNEYRKRFMLKPYESFEELTGEKEMSAELEAL
YGDIDAVELYPALLVEKPRPDAIFGETMVEVGAPFSLKGLMGNVICSPAYWKPSTFGGEV
GFQIINTASIQSLICNNVKGCPFTSFSVPDPELIKTVTINASSSRSGLDDINPTVLLKER
STEL
Drugs and Mode of Action
Drug(s) Aminosalicylic Acid Drug Info Approved Inflammatory bowel disease [551871]
Carprofen Drug Info Approved Pain [538508], [542149]
Celecoxib Drug Info Approved Rheumatold arthritis; Osteoarthritis [536772], [539915]
Diflunisal Drug Info Approved Pain [538256], [542171]
Etodolac Drug Info Approved Pain [538288], [542196]
Etoricoxib Drug Info Approved Rheumatold arthritis; Osteoarthritis [536058], [539919]
FENBUFEN Drug Info Approved Arthritis [551871]
Flufenamic Acid Drug Info Approved Dysmenorrhea [539575], [551871]
Flurbiprofen Drug Info Approved Rheumatoid arthritis [467529], [538273]
Ibuprofen Drug Info Approved Pain [536772], [539773]
Indomethacin Drug Info Approved Moderate to severe rheumatoid arthritis [551871]
Ketoprofen Drug Info Approved Rheumatold arthritis; Pain [468024], [538253]
Lumiracoxib Drug Info Approved Knee osteoarthritis [536058], [539920]
Meclofenamate Sodium Drug Info Approved Joint and muscular pain; Arthritis; Dysmenorrhea [551871]
Mefenamic acid Drug Info Approved Rheumatold arthritis; Osteoarthritis; Dysmenorrhea [538469], [539671], [551871]
Meloxicam Drug Info Approved Arthritis [524822], [542235], [551871]
Nabumetone Drug Info Approved Pain [523116], [542262]
Naproxen Drug Info Approved Osteoarthritis; Rheumatoid arthritis [551871]
Niflumic Acid Drug Info Approved Rheumatoid arthritis; Dysmenorrhea [539567], [550701], [551871]
Phenylbutazone Drug Info Approved Chronic pain; Ankylosing spondylitis [536447], [542290], [551871]
Rofecoxib Drug Info Approved Osteoarthritis [536772], [539916]
Tenoxicam Drug Info Approved Rheumatold arthritis; Osteoarthritis [527467], [527583], [550768]
Tiaprofenic acid Drug Info Approved Pain; Osteoarthritis [550690], [551871]
Tolmetin Drug Info Approved Rheumatold arthritis; Osteoarthritis [538251], [542334], [551871]
Valdecoxib Drug Info Approved Osteoarthritis; Rheumatoid arthritis [536232], [539917]
IMRECOXIB Drug Info Phase 4 Discovery agent [524526]
Celecoxib Drug Info Phase 3 Pain [536772], [539915]
CG-100649 Drug Info Phase 3 Arthritis [524183], [543067]
Curcumin Drug Info Phase 3 Cancer [532348], [542031]
diclofenac sodium patch Drug Info Phase 3 Unspecified [1559699]
DOCOSAHEXAENOIC ACID Drug Info Phase 3 Alzheimer disease [538634]
Ketoprofen Drug Info Phase 3 Pain [526212], [526261]
ketoprofen patch Drug Info Phase 3 Unspecified [526212], [526261]
ThermoProfen Drug Info Phase 3 Pain [522046]
Darbufelone Drug Info Phase 2/3 Asthma [532278]
CIMICOXIB Drug Info Phase 2 Pain [522081]
FK-3311 Drug Info Phase 2 Rheumatoid arthritis [528936]
Naproxen Drug Info Phase 2 Pain [468283], [523066]
SC-75416 Drug Info Phase 2 Pain [549824]
RWJ-67657 Drug Info Phase 1 Arthritis [525614]
INDOPROFEN Drug Info Withdrawn from market Gout [551871]
Nimesulide Drug Info Withdrawn from market Discovery agent [523284], [542424]
GW-406381 Drug Info Discontinued in Phase 3 Osteoarthritis; Neuropathic pain [536374]
PRINOMIDE TROMETHAMINE Drug Info Discontinued in Phase 3 Inflammation [544513]
Apricoxib Drug Info Discontinued in Phase 2 Non-small cell lung cancer; Pancreatic cancer; Rheumatoid arthritis [548493]
CRx-401 Drug Info Discontinued in Phase 2 Type 2 diabetes [547745]
GSK-644784 Drug Info Discontinued in Phase 2 Neuropathic pain [536374]
R-KETOPROFEN Drug Info Discontinued in Phase 2 Discovery agent [546255]
RQ-00317076 Drug Info Discontinued in Phase 2 Pain [549268]
S-2474 Drug Info Discontinued in Phase 2 Rheumatoid arthritis [546762]
TEBUFELONE Drug Info Discontinued in Phase 2 Pain [545171]
Tilmacoxib Drug Info Discontinued in Phase 2 Colon polyps [546604]
DUP 697 Drug Info Discontinued in Phase 1 Pain [544772]
E-6087 Drug Info Discontinued in Phase 1 Pain [547425]
GR-253035 Drug Info Discontinued in Phase 1 Alzheimer disease [546666]
SC-57666 Drug Info Discontinued in Phase 1 Rheumatoid arthritis [546187]
ATLIPROFEN METHYL ESTER Drug Info Terminated Inflammation [544774]
Flosulide Drug Info Terminated Pain [544771]
FR-123826 Drug Info Terminated Rheumatoid arthritis [546414]
L-745337 Drug Info Terminated Asthma [545938]
L-768277 Drug Info Terminated Hyperthermia [546606]
NMI-150 Drug Info Terminated Pain [547873]
NS398 Drug Info Terminated Pain; Endometriosis [545169]
ON-09300 Drug Info Terminated Cancer [547989]
RPR 200765A Drug Info Terminated Rheumatoid arthritis [547101]
RWJ-63556 Drug Info Terminated Arthritis [534446]
S-33516 Drug Info Terminated Arthritis [547095]
SB 203580 Drug Info Terminated Discovery agent [540732], [546259]
SC-236 Drug Info Terminated Cancer [547069]
SC-58125 Drug Info Terminated Discovery agent [545991]
SC-58451 Drug Info Terminated Discovery agent [546186]
Inhibitor (11H-Dibenzo[b,e][1,4]dioxepin-2-yl)-acetic acid Drug Info [533456]
(11H-Dibenzo[b,e][1,4]dioxepin-7-yl)-acetic acid Drug Info [533456]
(11H-Dibenzo[b,e][1,4]dioxepin-8-yl)-acetic acid Drug Info [533456]
(E)-2-(4-(methylsulfonyl)styryl)furan Drug Info [531229]
(E)-2-(4-(methylsulfonyl)styryl)thiophene Drug Info [531229]
(E)-3-(4-(methylsulfonyl)styryl)thiophene Drug Info [531229]
(E)-4-(2-(furan-2-yl)vinyl)benzenesulfonamide Drug Info [531229]
(E)-4-(2-(thiophen-2-yl)vinyl)benzenesulfonamide Drug Info [531229]
(E)-4-(2-(thiophen-3-yl)vinyl)benzenesulfonamide Drug Info [531229]
(R)-2-(4-Isobutyl-phenyl)-N-phenyl-propionamide Drug Info [527602]
(S)-FLURBIPROFEN Drug Info [527602]
(Z)-2'-des-methyl sulindac sulfide Drug Info [530116]
1,2-dihydro-3-(2,3,4-trimethoxyphenyl)naphthalene Drug Info [528934]
1,3-bis(nitrooxy)propan-2-yl 2-acetoxybenzoate Drug Info [530105]
1-(2-hydroxyphenyl)-3-p-tolylprop-2-en-1-one Drug Info [529976]
1-(4-(methylsulfonyl)phenyl)-1H-indole Drug Info [531135]
1-(4-(methylsulfonyl)phenyl)-1H-pyrrole Drug Info [531135]
1-(4-(methylsulfonyl)phenyl)-3-p-tolylurea Drug Info [529273]
1-(4-(methylsulfonyl)phenyl)-3-phenylurea Drug Info [529273]
1-(4-aminosulfonylphenyl)-2-(2-pyridyl)acetylene Drug Info [529156]
2'-hydroxy-3,4,5-trimethoxychalcone Drug Info [529976]
2'-Hydroxychalcone Drug Info [529976]
2,3-dimethoxy-2'-hydroxychalcone Drug Info [529976]
2,4'-Dimethoxy-5,3'-di-(2-propenyl)-biphenyl Drug Info [530176]
2,4'-Dimethoxy-5,3'-dipropyl-biphenyl Drug Info [530176]
2,4-dimethoxy-2'-hydroxychalcone Drug Info [529976]
2,6-dihydroxy-1,7-dimethoxyxanthone Drug Info [527828]
2-(2,3,4-trimethoxyphenyl)-1H-indene Drug Info [528934]
2-(2-(2,6-dimethylphenylamino)phenyl)acetic acid Drug Info [528789]
2-(3-Phenyl-propyl)-1,2-dihydro-indazol-3-one Drug Info [529474]
2-(4-(methylsulfonyl)phenyl)-3-phenylquinoline Drug Info [530629]
2-(4-(methylsulfonyl)phenyl)pyridine Drug Info [531135]
2-(N-(2-Ffuorophenyl)pyrrol-3-yl) acetic acid Drug Info [528854]
2-(N-(2-fluorophenyl)pyrrol-2-yl) acetic acid Drug Info [528854]
2-(p-Methylsulfonylbenzoyl)furan Drug Info [531135]
2-Benzyl-1,2-dihydro-indazol-3-one Drug Info [529474]
2-Furan-2-ylmethyl-1,2-dihydro-indazol-3-one Drug Info [529474]
2-Methyl-1,2-dihydro-indazol-3-one Drug Info [529474]
2-Naphthalen-2-ylmethyl-1,2-dihydro-indazol-3-one Drug Info [529474]
2-Phenethyl-1,2-dihydro-indazol-3-one Drug Info [529474]
2-Phenyl-1,2-dihydro-indazol-3-one Drug Info [529474]
3 beta-O-acetyloleanolic acid Drug Info [528272]
3,4-dibenzyloxy-2'-hydroxychalcone Drug Info [529976]
3,4-dihydroxyxanthone Drug Info [527828]
3-(4-Methanesulfonyl-phenyl)-1-phenyl-propynone Drug Info [527727]
3-benzyloxy-4-methoxy-2'-hydroxychalcone Drug Info [529976]
3-Bromo-2'-hydroxy-4-methoxychalcone Drug Info [529976]
4,5-Bis(4-chlorophenyl)-1,2-selenazole Drug Info [529127]
4,5-Bis(4-chlorophenyl)isothiazole Drug Info [529881]
4,5-Bis(4-methoxyphenyl)-1,2-selenazole Drug Info [529127]
4,5-Bis(4-methoxyphenyl)-3H-1,2-dithiol-3-one Drug Info [529881]
4,5-Bis(4-methoxyphenyl)isothiazole Drug Info [529881]
4-((4-methoxyphenyl)diazenyl)benzenesulfonamide Drug Info [528283]
4-(3-hydroxy-benzylideneamino)-benzenesulfonamide Drug Info [529203]
4-(3-methoxy-benzylideneamino)-benzenesulfonamide Drug Info [529203]
4-(3-nitro-benzylideneamino)-benzenesulfonamide Drug Info [529203]
4-(4-Chlorophenyl)-5-p-tolyl-1,2-selenazole Drug Info [529127]
4-(4-fluoro-benzylideneamino)-benzenesulfonamide Drug Info [529203]
4-(4-fluoro-phenyliminomethyl)-benzenesulfonamide Drug Info [529203]
4-(4-hydroxy-benzylideneamino)-benzenesulfonamide Drug Info [529203]
4-(4-methoxy-benzylideneamino)-benzenesulfonamide Drug Info [529203]
4-(4-methyl-benzylideneamino)-benzenesulfonamide Drug Info [529203]
4-(4-methyl-phenyliminomethyl)-benzenesulfonamide Drug Info [529203]
4-(4-nitro-benzylideneamino)-benzenesulfonamide Drug Info [529203]
4-(benzylideneamino)benzenesulfonamide Drug Info [529203]
4-amino-N-(4-chlorophenyl)benzenesulfonamide Drug Info [528508]
4-amino-N-(4-iodophenyl)benzenesulfonamide Drug Info [528508]
4-benzyloxy-2'-hydroxychalcone Drug Info [529976]
4-fluoro-N-(4-(methylsulfonyl)phenyl)aniline Drug Info [531135]
4-phenyliminomethyl-benzenesulfonamide Drug Info [529203]
5,3'-Dipropyl-biphenyl-2,4'-diol Drug Info [530176]
5-(2-Imidazol-1-yl-ethyl)-7,8-dihydro-quinoline Drug Info [525760]
5-(4-Chlorophenyl)-4-p-tolyl-1,2-selenazole Drug Info [529127]
5-(4-Methoxyphenyl)-4-p-tolyl-1,2-selenazole Drug Info [529127]
5-Ethyl-3,4-diphenyl-isoxazole Drug Info [527215]
5-methoxy-2-(4-(methylsulfonyl)phenyl)-1H-indole Drug Info [530236]
5-Methyl-3,4-diphenyl-isoxazole Drug Info [527215]
5-Phenyl-pentanoic acid benzyl-hydroxy-amide Drug Info [532882]
5-thia-8,11,14,17-eicosatetraenoic acid Drug Info [526089]
6,7'-oxybis(2-phenyl-4H-chromen-4-one) Drug Info [529827]
8alpha,19-dihydroxylabd-13 E-en-15-oic acid Drug Info [529467]
Apricoxib Drug Info [530463]
B-Octylglucoside Drug Info [551393]
Bimetopyrole Drug Info [536606]
Carprofen Drug Info [536327]
Celecoxib Drug Info [536549], [549843], [549974]
CG-100649 Drug Info [532911]
CLEMATOMANDSHURICA SAPONIN A Drug Info [528538]
CLEMATOMANDSHURICA SAPONIN B Drug Info [528538]
COX-2 inhibitors Drug Info [543413]
CR-4174 Drug Info [543413]
CRx-401 Drug Info [522072]
Curcumin Drug Info [527489]
CX-9051 Drug Info [543413]
DFU Drug Info [535003]
Diflunisal Drug Info [535160]
DOCOSAHEXAENOIC ACID Drug Info [526089]
DUP 697 Drug Info [536606]
E-6087 Drug Info [527028], [551871]
Etodolac Drug Info [535206], [536446]
Etoricoxib Drug Info [537000], [537380]
FENBUFEN Drug Info [530153]
Firocoxib Drug Info [525574]
Flufenamic Acid Drug Info [551392]
Fluoro loxoprofen Drug Info [531221]
FR-123826 Drug Info [546415]
Furan-3-yl(4-(methylsulfonyl)phenyl)methanone Drug Info [531135]
GSK-644784 Drug Info [536374]
GW-406381 Drug Info [536374]
GW-637185X Drug Info [530203]
Heme Drug Info [551374]
HONOKIOL Drug Info [530176]
Ibuprofen Drug Info [535585], [537246], [538149]
IMRECOXIB Drug Info [530021]
INDOPROFEN Drug Info [527602]
Ketoprofen Drug Info [536440]
L-748780 Drug Info [551313]
L-761000 Drug Info [551313]
LINOLENIC ACID Drug Info [526089]
LM-4108 Drug Info [530627]
Lumiracoxib Drug Info [537120]
Mefenamic acid Drug Info [538129]
Meloxicam Drug Info [534421]
METHYLHONOKIOL Drug Info [530176]
Microxine Drug Info [537922]
N-(1H-indazol-5-yl)acetamide Drug Info [529838]
N-(3-(phenylthio)pyridin-4-yl)methanesulfonamide Drug Info [530415]
N-(3-phenoxy-4-pyridinyl)ethanesulfonamide Drug Info [527352]
N-(3-phenylamino-4-pyridinyl)methanesulfonamide Drug Info [530415]
Nabumetone Drug Info [526187]
Naproxen Drug Info [525885]
Naproxene Drug Info [536772]
Nectamazin C Drug Info [530493]
NEOLIGNAN 9-NOR-7,8-DEHYDRO-ISOLICARIN B Drug Info [530493]
Niflumic Acid Drug Info [536416]
Nimesulide Drug Info [551378]
NMI-150 Drug Info [544345]
NS398 Drug Info [536772]
NSAIDs Drug Info [535528]
NSC-27236 Drug Info [528283]
OCOPHYLLALS A Drug Info [530493]
OCOPHYLLALS B Drug Info [530493]
Oxametacin Drug Info [529146]
PAC-10649 Drug Info [549744]
PHENIDONE Drug Info [529474]
Phenylbutazone Drug Info [536097]
Prifelone Drug Info [527799]
Primary alcohol metabolite of celecoxib Drug Info [529754]
PRINOMIDE TROMETHAMINE Drug Info [526385], [551871]
Prostaglandin G2 Drug Info [551374]
R-KETOPROFEN Drug Info [527602]
Resveratrol Potassium3-Sulfate Drug Info [530955]
Resveratrol Potassium4,-Sulfate Drug Info [530955]
Rofecoxib Drug Info [535528], [535660], [535785], [535836], [536549]
RPR 200765A Drug Info [535126]
RQ-00317076 Drug Info [551562]
RWJ-67657 Drug Info [535386]
S-2474 Drug Info [526157]
S-33516 Drug Info [549752]
SB 202190 Drug Info [535059]
SB 203580 Drug Info [535005]
SB 239063 Drug Info [535290]
SC-236 Drug Info [527033]
SC-558 Drug Info [530753]
SC-57666 Drug Info [534599]
SC-58125 Drug Info [530207]
SC-58451 Drug Info [551307]
SC-75416 Drug Info [529055]
Silicon-modified indomethacin Drug Info [543413]
TEBUFELONE Drug Info [534599]
TENOSAL Drug Info [550917], [551871]
Tenoxicam Drug Info [536034], [536149]
ThermoProfen Drug Info [530772]
THIOCTIC ACID Drug Info [529127]
Tiaprofenic acid Drug Info [537672]
Tilmacoxib Drug Info [526297]
Tolmetin Drug Info [537246]
Topical etoricoxib Drug Info [543413]
Valdecoxib Drug Info [536232]
WOGONIN Drug Info [529976]
XGP-110 Drug Info [543413]
Modulator Aminosalicylic Acid Drug Info [556264]
ATLIPROFEN METHYL ESTER Drug Info [556264]
CIMICOXIB Drug Info
Darbufelone Drug Info [532278]
diclofenac sodium patch Drug Info
FK-3311 Drug Info [528936]
Flosulide Drug Info [525636]
Flurbiprofen Drug Info
GR-253035 Drug Info [544016]
Indomethacin Drug Info [556264]
ketoprofen patch Drug Info [526212], [526261]
L-745337 Drug Info
L-768277 Drug Info [551650]
Meclofenamate Sodium Drug Info
Nitroflurbiprofen Drug Info
ON-09300 Drug Info [556264]
RWJ-63556 Drug Info [534446]
Regulator (upregulator) C-myb Drug Info [534981]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
DRM DRM Info
Pathways
BioCyc Pathway Aspirin-triggered lipoxin biosynthesis
Aspirin triggered resolvin D biosynthesis
C20 prostanoid biosynthesis
Aspirin triggered resolvin E biosynthesis
KEGG Pathway Arachidonic acid metabolism
Metabolic pathways
NF-kappa B signaling pathway
VEGF signaling pathway
TNF signaling pathway
Retrograde endocannabinoid signaling
Serotonergic synapse
Ovarian steroidogenesis
Oxytocin signaling pathway
Regulation of lipolysis in adipocytes
Leishmaniasis
Pathways in cancer
Chemical carcinogenesis
MicroRNAs in cancer
Small cell lung cancer
NetPath Pathway IL1 Signaling Pathway
TSH Signaling Pathway
IL4 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
IL5 Signaling Pathway
PANTHER Pathway Endothelin signaling pathway
Inflammation mediated by chemokine and cytokine signaling pathway
Toll receptor signaling pathway
CCKR signaling map ST
Pathway Interaction Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes
S1P1 pathway
C-MYB transcription factor network
Signaling mediated by p38-alpha and p38-beta
Calcium signaling in the CD4+ TCR pathway
PathWhiz Pathway Arachidonic Acid Metabolism
WikiPathways Prostaglandin Synthesis and Regulation
Arachidonic acid metabolism
Aryl Hydrocarbon Receptor
Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
Spinal Cord Injury
Integrated Pancreatic Cancer Pathway
Eicosanoid Synthesis
Selenium Micronutrient Network
References
Ref 467529(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4194).
Ref 468024(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4795).
Ref 468283(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5230).
Ref 522046ClinicalTrials.gov (NCT00488267) Efficacy of ThermoProfen in Patients With Mild to Moderate Pain Associated With Osteoarthritis of the Knee. U.S. National Institutes of Health.
Ref 522081ClinicalTrials.gov (NCT00510822) Cimicoxib for the Treatment of Major Depression (SECIM). U.S. National Institutes of Health.
Ref 523066ClinicalTrials.gov (NCT01139190) Clinical Trial Evaluating Gastrointestinal Damage Following Administration PL3100 or Naproxen in At-Risk Adults. U.S. National Institutes of Health.
Ref 523116ClinicalTrials.gov (NCT01164826) Bioequivalence Study of Nabumetone 750 mg Tablets of Dr. Reddy's Under Fed Conditions. U.S. National Institutes of Health.
Ref 523284ClinicalTrials.gov (NCT01257126) Efficacy of Diclofenac Potassium vs Nimesulide in the Treatment of Fever and Pain in Children With Upper Respiratory Tract Infection. U.S. National Institutes of Health.
Ref 524183ClinicalTrials.gov (NCT01765296) Phase III Study of CG100649 in Osteoarthritis Patients. U.S. National Institutes of Health.
Ref 524526ClinicalTrials.gov (NCT01985165) A Phase 4 Study of Imrecoxib in Treatment of Knee Osteoarthritis. U.S. National Institutes of Health.
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