| Drug General Information |
| Drug ID |
D0B2WJ
|
| Former ID |
DNC002446
|
| Drug Name |
Flufenamic Acid
|
| Drug Type |
Small molecular drug
|
| Indication |
Dysmenorrhea [ICD9: 625.3; ICD10:N94.4-N94.6]
|
Approved |
[1],
[2]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C14H10F3NO2
|
| InChI |
InChI=1S/C14H10F3NO2/c15-14(16,17)9-4-3-5-10(8-9)18-12-7-2-1-6-11(12)13(19)20/h1-8,18H,(H,19,20)
|
| InChIKey |
LPEPZBJOKDYZAD-UHFFFAOYSA-N
|
| CAS Number |
CAS 530-78-9
|
| PubChem Compound ID |
|
| PubChem Substance ID |
121213, 129884, 583427, 825185, 832225, 855855, 3136545, 3296204, 5329923, 7848644, 7887502, 7979236, 8149699, 8152145, 10321320, 10525534, 11112395, 11119923, 11120411, 11120899, 11121384, 11121864, 11141586, 11147006, 11335756, 11360995, 11362453, 11364151, 11364681, 11365015, 11366713, 11367243, 11367577, 11369275, 11369805, 11370177, 11370178, 11372465, 11372846, 11373178, 11373563, 11375405, 11375739, 11377437, 11377968, 11461967, 11466231, 11467351, 11484634, 11485842
|
| SuperDrug ATC ID |
M01AG03
|
| Target and Pathway |
| Target(s) |
Androgen receptor |
Target Info |
Inhibitor |
[3]
|
|---|
| Prostaglandin G/H synthase 2 |
Target Info |
Inhibitor |
[3]
|
| Prostaglandin G/H synthase 1 |
Target Info |
Inhibitor |
[3]
|
| Aldo-keto reductase family 1 member C3 |
Target Info |
Inhibitor |
[3]
|
|
BioCyc Pathway
|
Aspirin-triggered lipoxin biosynthesis
|
|
Aspirin triggered resolvin D biosynthesis
|
|
C20 prostanoid biosynthesis
|
|
Aspirin triggered resolvin E biosynthesisPWY66-374:C20 prostanoid biosynthesisPWY-7305:Superpathway of steroid hormone biosynthesis
|
|
Allopregnanolone biosynthesis
|
|
Androgen biosynthesis
|
|
KEGG Pathway
|
Oocyte meiosis
|
|
Pathways in cancer
|
|
Prostate cancerhsa00590:Arachidonic acid metabolism
|
|
Metabolic pathways
|
|
NF-kappa B signaling pathway
|
|
VEGF signaling pathway
|
|
TNF signaling pathway
|
|
Retrograde endocannabinoid signaling
|
|
Serotonergic synapse
|
|
Ovarian steroidogenesis
|
|
Oxytocin signaling pathway
|
|
Regulation of lipolysis in adipocytes
|
|
Leishmaniasis
|
|
Chemical carcinogenesis
|
|
MicroRNAs in cancer
|
|
Small cell lung cancerhsa00590:Arachidonic acid metabolism
|
|
Platelet activation
|
|
Serotonergic synapsehsa00140:Steroid hormone biosynthesis
|
|
Arachidonic acid metabolism
|
|
NetPath Pathway
|
EGFR1 Signaling Pathway
|
|
AndrogenReceptor Signaling Pathway
|
|
FSH Signaling PathwayNetPath_13:IL1 Signaling Pathway
|
|
TSH Signaling Pathway
|
|
IL4 Signaling Pathway
|
|
TGF_beta_Receptor Signaling Pathway
|
|
IL5 Signaling PathwayNetPath_7:TGF_beta_Receptor Signaling PathwayNetPath_7:TGF_beta_Receptor Signaling Pathway
|
|
PANTHER Pathway
|
Endothelin signaling pathway
|
|
Inflammation mediated by chemokine and cytokine signaling pathway
|
|
Toll receptor signaling pathway
|
|
CCKR signaling map STP00031:Inflammation mediated by chemokine and cytokine signaling pathway
|
|
Pathway Interaction Database
|
Regulation of nuclear SMAD2/3 signaling
|
|
Coregulation of Androgen receptor activity
|
|
Regulation of Androgen receptor activity
|
|
Nongenotropic Androgen signaling
|
|
Regulation of nuclear beta catenin signaling and target gene transcription
|
|
FOXA1 transcription factor network
|
|
Notch-mediated HES/HEY networknfat_tfpathway:Calcineurin-regulated NFAT-dependent transcription in lymphocytes
|
|
S1P1 pathway
|
|
C-MYB transcription factor network
|
|
Signaling mediated by p38-alpha and p38-beta
|
|
Calcium signaling in the CD4+ TCR pathway
|
|
PathWhiz Pathway
|
Arachidonic Acid MetabolismPW000044:Arachidonic Acid MetabolismPW000044:Arachidonic Acid Metabolism
|
|
Reactome
|
Nuclear Receptor transcription pathway
|
|
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3R-HSA-975634:Retinoid metabolism and transport
|
|
WikiPathways
|
SIDS Susceptibility Pathways
|
|
Integrated Pancreatic Cancer Pathway
|
|
Prostate Cancer
|
|
Integrated Breast Cancer Pathway
|
|
Nuclear Receptors
|
|
Androgen receptor signaling pathwayWP98:Prostaglandin Synthesis and Regulation
|
|
Arachidonic acid metabolism
|
|
Aryl Hydrocarbon Receptor
|
|
Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
|
|
Spinal Cord Injury
|
|
Eicosanoid Synthesis
|
|
Selenium Micronutrient NetworkWP98:Prostaglandin Synthesis and Regulation
|
|
Phase 1 - Functionalization of compounds
|
|
Selenium Micronutrient NetworkWP702:Metapathway biotransformation
|
|
Benzo(a)pyrene metabolism
|
| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2447). |
|---|
| REF 2 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 |
|---|
| REF 3 | Ouellet M, Percival MD: Effect of inhibitor time-dependency on selectivity towards cyclooxygenase isoforms. Biochem J. 1995 Feb 15;306 ( Pt 1):247-51. |
|---|
