Drug General Information
Drug ID	D05REH
Former ID	DIB011182
Drug Name	Flosulide
Synonyms	CGP-28238; CGP-28328; CGS-28238; SH-459; ZK-38997
Drug Type	Small molecular drug
Indication	Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89]		Terminated	[544771]
Company	Novartis AG
Structure		Download 2D MOL 3D MOL
Formula	C16H13F2NO4S
Canonical SMILES	S(=O)(=O)(Nc1c(cc2c(c1)CCC2=O)Oc1c(cc(cc1)F)F)C
CAS Number	CAS 80937-31-1
PubChem Compound ID	71246
Target and Pathway
Target(s)	Prostaglandin G/H synthase 2	Target Info	Modulator	[525636]
BioCyc Pathway	Aspirin-triggered lipoxin biosynthesis
	Aspirin triggered resolvin D biosynthesis
	C20 prostanoid biosynthesis
	Aspirin triggered resolvin E biosynthesis
KEGG Pathway	Arachidonic acid metabolism
	Metabolic pathways
	NF-kappa B signaling pathway
	VEGF signaling pathway
	TNF signaling pathway
	Retrograde endocannabinoid signaling
	Serotonergic synapse
	Ovarian steroidogenesis
	Oxytocin signaling pathway
	Regulation of lipolysis in adipocytes
	Leishmaniasis
	Pathways in cancer
	Chemical carcinogenesis
	MicroRNAs in cancer
	Small cell lung cancer
NetPath Pathway	IL1 Signaling Pathway
	TSH Signaling Pathway
	IL4 Signaling Pathway
	TGF_beta_Receptor Signaling Pathway
	IL5 Signaling Pathway
PANTHER Pathway	Endothelin signaling pathway
	Inflammation mediated by chemokine and cytokine signaling pathway
	Toll receptor signaling pathway
	CCKR signaling map ST
Pathway Interaction Database	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
	S1P1 pathway
	C-MYB transcription factor network
	Signaling mediated by p38-alpha and p38-beta
	Calcium signaling in the CD4+ TCR pathway
PathWhiz Pathway	Arachidonic Acid Metabolism
WikiPathways	Prostaglandin Synthesis and Regulation
	Arachidonic acid metabolism
	Aryl Hydrocarbon Receptor
	Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
	Spinal Cord Injury
	Integrated Pancreatic Cancer Pathway
	Eicosanoid Synthesis
	Selenium Micronutrient Network
References
Ref 544771	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000942)
Ref 525636	Effect of flosulide, a selective cyclooxygenase 2 inhibitor, on passive heymann nephritis in the rat. Kidney Int. 1999 Nov;56(5):1770-8.

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