Drug Information
Drug General Information | |||||
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Drug ID |
D04TNI
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Drug Name |
Nitroflurbiprofen
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Synonyms |
Flurbinitroxybutylester; Flurbiprofen nitroxybutylester; HCT 1026; NO-flurbiprofen
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Drug Type |
Small molecular drug
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Structure |
Download2D MOL |
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Formula |
C19H20FNO5
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | Prostaglandin G/H synthase 1 | Target Info | Modulator | ||
Prostaglandin G/H synthase 2 | Target Info | Modulator | |||
KEGG Pathway | Arachidonic acid metabolism | ||||
Metabolic pathways | |||||
Platelet activation | |||||
Serotonergic synapsehsa00590:Arachidonic acid metabolism | |||||
NF-kappa B signaling pathway | |||||
VEGF signaling pathway | |||||
TNF signaling pathway | |||||
Retrograde endocannabinoid signaling | |||||
Serotonergic synapse | |||||
Ovarian steroidogenesis | |||||
Oxytocin signaling pathway | |||||
Regulation of lipolysis in adipocytes | |||||
Leishmaniasis | |||||
Pathways in cancer | |||||
Chemical carcinogenesis | |||||
MicroRNAs in cancer | |||||
Small cell lung cancer | |||||
PathWhiz Pathway | Arachidonic Acid MetabolismPW000044:Arachidonic Acid Metabolism | ||||
WikiPathways | Prostaglandin Synthesis and Regulation | ||||
Arachidonic acid metabolism | |||||
Phase 1 - Functionalization of compounds | |||||
Eicosanoid Synthesis | |||||
Selenium Micronutrient NetworkWP98:Prostaglandin Synthesis and Regulation | |||||
Aryl Hydrocarbon Receptor | |||||
Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis | |||||
Spinal Cord Injury | |||||
Integrated Pancreatic Cancer Pathway | |||||
Selenium Micronutrient Network | |||||
References | |||||
Ref 1559748 | Flurbiprofen, a cyclooxygenase inhibitor, protects mice from hepatic ischemia/reperfusion injury by inhibiting GSK-3 signaling and mitochondrial permeability transition.Mol Med.2012 Sep 25;18:1128-35. | ||||
Ref 1559749 | Flurbiprofen: A Nonselective Cyclooxygenase (COX) Inhibitor for Treatment of Noninfectious, Non-necrotizing Anterior Scleritis.Ocul Immunol Inflamm.2016;24(1):35-42. | ||||
Ref 1560392 | The cyclooxygenase inhibitor flurbiprofen reduces radiation-induced angiogenic growth factor secretion of squamous cell carcinoma cell lines. |
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