Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D06OZJ
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| Former ID |
DNC001245
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| Drug Name |
RWJ-67657
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| Drug Type |
Small molecular drug
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| Indication | Arthritis [ICD9: 710-719; ICD10:M00-M25] | Phase 1 | [525614] | ||
| Therapeutic Class |
Analgesics
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| Structure |
|
Download2D MOL |
|||
| Formula |
C27H24FN3O
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| Canonical SMILES |
C1=CC=C(C=C1)CCCN2C(=NC(=C2C3=CC=NC=C3)C4=CC=C(C=C4)F)C<br />#CCCO
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| InChI |
1S/C27H24FN3O/c28-24-13-11-22(12-14-24)26-27(23-15-17-29-18-16-23)31(25(30-26)10-4-5-20-32)19-6-9-21-7-2-1-3-8-21/h1-3,7-8,11-18,32H,5-6,9,19-20H2
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| InChIKey |
QSUSKMBNZQHHPA-UHFFFAOYSA-N
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| CAS Number |
CAS 215303-72-3
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| PubChem Compound ID | |||||
| PubChem Substance ID |
3720130, 10038746, 14782797, 36057105, 57410202, 79140398, 103461888, 104137084, 111624293, 124950173, 125697878, 126671721, 129070177, 134340457, 135141704, 135685296, 135685297, 135685316, 135698854, 137275843, 140058336, 152344436, 162815368, 164233574, 164764920, 174560978, 180371708, 204360619, 223664282, 223798817, 226524969, 241376206, 249617731, 252156935, 252216243, 252543343
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| Target and Pathway | |||||
| Target(s) | Prostaglandin G/H synthase 2 | Target Info | Inhibitor | [535386] | |
| KEGG Pathway | Arachidonic acid metabolism | ||||
| Metabolic pathways | |||||
| NF-kappa B signaling pathway | |||||
| VEGF signaling pathway | |||||
| TNF signaling pathway | |||||
| Retrograde endocannabinoid signaling | |||||
| Serotonergic synapse | |||||
| Ovarian steroidogenesis | |||||
| Oxytocin signaling pathway | |||||
| Regulation of lipolysis in adipocytes | |||||
| Leishmaniasis | |||||
| Pathways in cancer | |||||
| Chemical carcinogenesis | |||||
| MicroRNAs in cancer | |||||
| Small cell lung cancer | |||||
| PathWhiz Pathway | Arachidonic Acid Metabolism | ||||
| References | |||||
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