| Drug General Information |
| Drug ID |
D0C0JT
|
| Former ID |
DNC003303
|
| Drug Name |
Nimesulide
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Withdrawn from market |
[1],
[2]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C13H12N2O5S
|
| InChI |
InChI=1S/C13H12N2O5S/c1-21(18,19)14-12-8-7-10(15(16)17)9-13(12)20-11-5-3-2-4-6-11/h2-9,14H,1H3
|
| InChIKey |
HYWYRSMBCFDLJT-UHFFFAOYSA-N
|
| CAS Number |
CAS 51803-78-2
|
| PubChem Compound ID |
|
| PubChem Substance ID |
855635, 5912186, 6436673, 7404099, 7848112, 7889413, 7980127, 8149946, 8152768, 10321585, 11111520, 11111521, 11121727, 11122207, 11335868, 11361107, 11362857, 11364471, 11365419, 11367033, 11367981, 11369595, 11370925, 11370926, 11372711, 11373582, 11373834, 11376143, 11377757, 11462079, 11466222, 11467342, 11485118, 11485804, 11489357, 11491391, 11491993, 11495391, 12012650, 14752054, 17405416, 24277576, 24278583, 26612437, 26680139, 26697157, 26746940, 26746941, 26751468, 29215000
|
| SuperDrug ATC ID |
M01AX17; M02AA26
|
| Target and Pathway |
| Target(s) |
Prostaglandin G/H synthase 2 |
Target Info |
Inhibitor |
[3]
|
|---|
| Lactotransferrin |
Target Info |
Inhibitor |
[3]
|
|
BioCyc Pathway
|
Aspirin-triggered lipoxin biosynthesis
|
|
Aspirin triggered resolvin D biosynthesis
|
|
C20 prostanoid biosynthesis
|
|
Aspirin triggered resolvin E biosynthesis
|
|
KEGG Pathway
|
Arachidonic acid metabolism
|
|
Metabolic pathways
|
|
NF-kappa B signaling pathway
|
|
VEGF signaling pathway
|
|
TNF signaling pathway
|
|
Retrograde endocannabinoid signaling
|
|
Serotonergic synapse
|
|
Ovarian steroidogenesis
|
|
Oxytocin signaling pathway
|
|
Regulation of lipolysis in adipocytes
|
|
Leishmaniasis
|
|
Pathways in cancer
|
|
Chemical carcinogenesis
|
|
MicroRNAs in cancer
|
|
Small cell lung cancer
|
|
NetPath Pathway
|
IL1 Signaling Pathway
|
|
TSH Signaling Pathway
|
|
IL4 Signaling Pathway
|
|
TGF_beta_Receptor Signaling Pathway
|
|
IL5 Signaling PathwayNetPath_7:TGF_beta_Receptor Signaling Pathway
|
|
TCR Signaling Pathway
|
|
PANTHER Pathway
|
Endothelin signaling pathway
|
|
Inflammation mediated by chemokine and cytokine signaling pathway
|
|
Toll receptor signaling pathway
|
|
CCKR signaling map ST
|
|
Pathway Interaction Database
|
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
|
|
S1P1 pathway
|
|
C-MYB transcription factor network
|
|
Signaling mediated by p38-alpha and p38-beta
|
|
Calcium signaling in the CD4+ TCR pathway
|
|
PathWhiz Pathway
|
Arachidonic Acid Metabolism
|
|
Reactome
|
ROS production in response to bacteria
|
|
Amyloid formation
|
|
WikiPathways
|
Prostaglandin Synthesis and Regulation
|
|
Arachidonic acid metabolism
|
|
Aryl Hydrocarbon Receptor
|
|
Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
|
|
Spinal Cord Injury
|
|
Integrated Pancreatic Cancer Pathway
|
|
Eicosanoid Synthesis
|
|
Selenium Micronutrient NetworkWP2700:Latent infection of Homo sapiens with Mycobacterium tuberculosis
|
| References |
| REF 1 | ClinicalTrials.gov (NCT01257126) Efficacy of Diclofenac Potassium vs Nimesulide in the Treatment of Fever and Pain in Children With Upper Respiratory Tract Infection. U.S. National Institutes of Health. |
|---|
| REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7401). |
|---|
| REF 3 | Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. |
|---|
