Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0S7VO
|
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| Former ID |
DAP000973
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| Drug Name |
Tiaprofenic acid
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| Synonyms |
Surgam; Tiaprofensaeure; Acide tiaprofenique; Acido tiaprofenico; Acidum tiaprofenicum; Surgam SR; FC 3001; RU 15060; Acide tiaprofenique [INN-French]; Acido tiaprofenico [INN-Spanish]; Acidum tiaprofenicum [INN-Latin]; Apo-Tiaprofenic Tablets; Dom-tiaprofenic; Surgam (TN); Surgamyl (TN); Tiaprofen (TN); Tiaprofenic acid (JAN/INN); Tiaprofenic-200-Tab; Tiaprofenic-300-Tab; Tiaprofenic acid [INN:BAN:DCF:JAN]; Alpha-methyl-5-benzoyl-2-thienylacetic acid; 2-(5-Benzyl-2-thienyl)propionsaeure; 2-(5-benzoylthiophen-2-yl)propanoic acid; 2-[5-(phenylcarbonyl)-2-thienyl]propanoic acid; 5-Benzoyl-alpha-methyl-2-thiopheneacetic acid; 5-benzoyl-alpha-methylthiophene-2-acetic acid
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| Drug Type |
Small molecular drug
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| Indication | Pain; Osteoarthritis [ICD9: 338, 356.0, 356.8, 780, 715; ICD10:G64, G90.0, R52, G89, M15-M19, M47] | Approved | [1], [2] | ||
| Therapeutic Class |
Analgesics
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| Structure |
|
Download2D MOL |
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| Formula |
C14H12O3S
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| Canonical SMILES |
CC(C1=CC=C(S1)C(=O)C2=CC=CC=C2)C(=O)O
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| InChI |
1S/C14H12O3S/c1-9(14(16)17)11-7-8-12(18-11)13(15)10-5-3-2-4-6-10/h2-9H,1H3,(H,16,17)
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| InChIKey |
GUHPRPJDBZHYCJ-UHFFFAOYSA-N
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| CAS Number |
CAS 33005-95-7
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| PubChem Compound ID | |||||
| PubChem Substance ID |
5650057, 7848388, 7980789, 8153359, 10321760, 11466524, 11467644, 11486048, 15197037, 29224513, 46504590, 47879648, 48029210, 48104706, 48403971, 48416624, 49698523, 50053804, 51058482, 56463054, 57322793, 85788872, 92125357, 92729714, 96079567, 103459194, 103914245, 104309320, 121363028, 124799389, 126452085, 126626764, 126645614, 128007314, 134338244, 135049034, 137237350, 140021568, 144204178, 152108477, 160964837, 162311284, 162313185, 162838029, 163693606, 164765592, 170465577, 172820851, 175442537, 175611886
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| SuperDrug ATC ID |
M01AE11
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| SuperDrug CAS ID |
cas=033005957
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| Target and Pathway | |||||
| Target(s) | Prostaglandin G/H synthase 2 | Target Info | Inhibitor | [3] | |
| BioCyc Pathway | Aspirin-triggered lipoxin biosynthesis | ||||
| Aspirin triggered resolvin D biosynthesis | |||||
| C20 prostanoid biosynthesis | |||||
| Aspirin triggered resolvin E biosynthesis | |||||
| KEGG Pathway | Arachidonic acid metabolism | ||||
| Metabolic pathways | |||||
| NF-kappa B signaling pathway | |||||
| VEGF signaling pathway | |||||
| TNF signaling pathway | |||||
| Retrograde endocannabinoid signaling | |||||
| Serotonergic synapse | |||||
| Ovarian steroidogenesis | |||||
| Oxytocin signaling pathway | |||||
| Regulation of lipolysis in adipocytes | |||||
| Leishmaniasis | |||||
| Pathways in cancer | |||||
| Chemical carcinogenesis | |||||
| MicroRNAs in cancer | |||||
| Small cell lung cancer | |||||
| NetPath Pathway | IL1 Signaling Pathway | ||||
| TSH Signaling Pathway | |||||
| IL4 Signaling Pathway | |||||
| TGF_beta_Receptor Signaling Pathway | |||||
| IL5 Signaling Pathway | |||||
| PANTHER Pathway | Endothelin signaling pathway | ||||
| Inflammation mediated by chemokine and cytokine signaling pathway | |||||
| Toll receptor signaling pathway | |||||
| CCKR signaling map ST | |||||
| Pathway Interaction Database | Calcineurin-regulated NFAT-dependent transcription in lymphocytes | ||||
| S1P1 pathway | |||||
| C-MYB transcription factor network | |||||
| Signaling mediated by p38-alpha and p38-beta | |||||
| Calcium signaling in the CD4+ TCR pathway | |||||
| PathWhiz Pathway | Arachidonic Acid Metabolism | ||||
| WikiPathways | Prostaglandin Synthesis and Regulation | ||||
| Arachidonic acid metabolism | |||||
| Aryl Hydrocarbon Receptor | |||||
| Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis | |||||
| Spinal Cord Injury | |||||
| Integrated Pancreatic Cancer Pathway | |||||
| Eicosanoid Synthesis | |||||
| Selenium Micronutrient Network | |||||
| References | |||||
| REF 1 | Drug information of Tiaprofenic acid, 2008. eduDrugs. | ||||
| REF 2 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | ||||
| REF 3 | Effects of tiaprofenic acid on the concentration and metabolism of proteoglycans in normal and degenerating canine articular cartilage. J Clin Pharmacol. 1990 Sep;30(9):808-14. | ||||
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