| Drug General Information |
| Drug ID |
D0U8OD
|
| Former ID |
DNC007166
|
| Drug Name |
CIMICOXIB
|
| Drug Type |
Small molecular drug
|
| Indication |
Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89]
|
Phase 2 |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C16H13ClFN3O3S
|
| Canonical SMILES |
COC1=C(C=C(C=C1)C2=C(N=CN2C3=CC=C(C=C3)S(=O)(=O)N)Cl)F
|
| InChIKey |
KYXDNECMRLFQMZ-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Prostaglandin G/H synthase 2 |
Target Info |
Modulator |
|
|---|
|
BioCyc Pathway
|
Aspirin-triggered lipoxin biosynthesis
|
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Aspirin triggered resolvin D biosynthesis
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C20 prostanoid biosynthesis
|
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Aspirin triggered resolvin E biosynthesis
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KEGG Pathway
|
Arachidonic acid metabolism
|
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Metabolic pathways
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NF-kappa B signaling pathway
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VEGF signaling pathway
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TNF signaling pathway
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Retrograde endocannabinoid signaling
|
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Serotonergic synapse
|
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Ovarian steroidogenesis
|
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Oxytocin signaling pathway
|
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Regulation of lipolysis in adipocytes
|
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Leishmaniasis
|
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Pathways in cancer
|
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Chemical carcinogenesis
|
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MicroRNAs in cancer
|
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Small cell lung cancer
|
|
NetPath Pathway
|
IL1 Signaling Pathway
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TSH Signaling Pathway
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IL4 Signaling Pathway
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TGF_beta_Receptor Signaling Pathway
|
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IL5 Signaling Pathway
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PANTHER Pathway
|
Endothelin signaling pathway
|
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Inflammation mediated by chemokine and cytokine signaling pathway
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Toll receptor signaling pathway
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CCKR signaling map ST
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|
Pathway Interaction Database
|
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
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S1P1 pathway
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C-MYB transcription factor network
|
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Signaling mediated by p38-alpha and p38-beta
|
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Calcium signaling in the CD4+ TCR pathway
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PathWhiz Pathway
|
Arachidonic Acid Metabolism
|
|
WikiPathways
|
Prostaglandin Synthesis and Regulation
|
|
Arachidonic acid metabolism
|
|
Aryl Hydrocarbon Receptor
|
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Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
|
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Spinal Cord Injury
|
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Integrated Pancreatic Cancer Pathway
|
|
Eicosanoid Synthesis
|
|
Selenium Micronutrient Network
|
| References |
| REF 1 | ClinicalTrials.gov (NCT00510822) Cimicoxib for the Treatment of Major Depression (SECIM). U.S. National Institutes of Health. |
|---|
