| Drug General Information |
| Drug ID |
D04DUJ
|
| Former ID |
DIB002534
|
| Drug Name |
S-2474
|
| Drug Type |
Small molecular drug
|
| Indication |
Rheumatoid arthritis [ICD9: 710-719, 714; ICD10:M05-M06]
|
Discontinued in Phase 2 |
[1]
|
|---|
| Company |
Shionogi & Co Ltd
|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C20H31NO3S
|
| Canonical SMILES |
CCN1CCC(=CC2=CC(=C(C(=C2)C(C)(C)C)O)C(C)(C)C)S1(=O)=O
|
| InChI |
1S/C20H31NO3S/c1-8-21-10-9-15(25(21,23)24)11-14-12-16(19(2,3)4)18(22)17(13-14)20(5,6)7/h11-13,22H,8-10H2,1-7H3
|
| InChIKey |
HFWZBWTWCKQUCB-UHFFFAOYSA-N
|
| CAS Number |
CAS 158089-95-3
|
| PubChem Compound ID |
|
| PubChem Substance ID |
|
| Target and Pathway |
| Target(s) |
Prostaglandin G/H synthase 2 |
Target Info |
Inhibitor |
[2]
|
|---|
|
BioCyc Pathway
|
Aspirin-triggered lipoxin biosynthesis
|
|
Aspirin triggered resolvin D biosynthesis
|
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C20 prostanoid biosynthesis
|
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Aspirin triggered resolvin E biosynthesis
|
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KEGG Pathway
|
Arachidonic acid metabolism
|
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Metabolic pathways
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NF-kappa B signaling pathway
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VEGF signaling pathway
|
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TNF signaling pathway
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Retrograde endocannabinoid signaling
|
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Serotonergic synapse
|
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Ovarian steroidogenesis
|
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Oxytocin signaling pathway
|
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Regulation of lipolysis in adipocytes
|
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Leishmaniasis
|
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Pathways in cancer
|
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Chemical carcinogenesis
|
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MicroRNAs in cancer
|
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Small cell lung cancer
|
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NetPath Pathway
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IL1 Signaling Pathway
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TSH Signaling Pathway
|
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IL4 Signaling Pathway
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TGF_beta_Receptor Signaling Pathway
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IL5 Signaling Pathway
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PANTHER Pathway
|
Endothelin signaling pathway
|
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Inflammation mediated by chemokine and cytokine signaling pathway
|
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Toll receptor signaling pathway
|
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CCKR signaling map ST
|
|
Pathway Interaction Database
|
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
|
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S1P1 pathway
|
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C-MYB transcription factor network
|
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Signaling mediated by p38-alpha and p38-beta
|
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Calcium signaling in the CD4+ TCR pathway
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PathWhiz Pathway
|
Arachidonic Acid Metabolism
|
|
WikiPathways
|
Prostaglandin Synthesis and Regulation
|
|
Arachidonic acid metabolism
|
|
Aryl Hydrocarbon Receptor
|
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Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
|
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Spinal Cord Injury
|
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Integrated Pancreatic Cancer Pathway
|
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Eicosanoid Synthesis
|
|
Selenium Micronutrient Network
|
| References |
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010176) |
|---|
| REF 2 | Effects of S-2474, a novel nonsteroidal anti-inflammatory drug, on amyloid beta protein-induced neuronal cell death. Br J Pharmacol. 2001 Oct;134(3):673-81. |
|---|
