Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0R1RS
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| Former ID |
DAP000617
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| Drug Name |
Indomethacin
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| Synonyms |
Aconip; Amuno; Arthrexin; Artracin; Artrinovo; Artrivia; Bonidin; Bonidon; Catlep; Confortid; Dolcidium; Dolovin; Durametacin; Elmetacin; Hicin; IMN; Idomethine; Imbrilon; Inacid; Indacin; Indameth; Indmethacine; Indocid; Indocin; Indomecol; Indomed; Indomee; Indometacin; Indometacina; Indometacine; Indometacinum; Indometacyna; Indomethacine; Indomethacinum; Indomethancin; Indomethazine; Indomethegan; Indomethine; Indometicina; Indomo; Indomod; Indoptic; Indoptol; Indorektal; Indoxen; Inflazon; Infrocin; Lausit; Liometacen; Metacen; Metartril; Methazine; Metindol; Mezolin; Miametan; Mikametan; Mobilan; Novomethacin; Reumacide; Sadoreum; Tannex; Vonum; Bonidon Gel; DESMETHYL INDOMETHACIN; Dolcidium PL;Flexin continus; Indocid Pda; Indocid Sr; Indocin Sr; Indolar SR; Indometacyna [Polish]; Indometicina [Spanish]; Inteban sp; Rhemacin LA; Rheumacin LA; I 7378; IN1454; Indomet 140; Aconip (TN); Apo-Indomethacin; Chibro-amuno; Chrono-indicid; Chrono-indocid; Indo-Lemmon; Indo-Spray; Indo-phlogont; Indo-rectolmin; Indo-tablinen; Indocid (TN); Indocid (pharmaceutical); Indocin (TN); Indocin I.V; Indometacina [INN-Spanish]; Indometacine [INN-French]; Indometacinum [INN-Latin]; Indomethacin (USP); Indomethacin [USAN:BAN]; Novo-Methacin; Indochron E-R (TN); Indocin I.V.; Indocin-SR (TN); Indometacin (JP15/INN); Indomethacin & MAP-30; Indomethacin, Indochron E-R, Indocin-SR, Indocid, Indocin, Indomethacin
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| Drug Type |
Small molecular drug
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| Indication | Moderate to severe rheumatoid arthritis [ICD10:M05-M06] | Approved | [1] | ||
| Therapeutic Class |
Antiinflammatory Agents
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| Company |
Recordati Rare Diseases Inc
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| Structure |
|
Download2D MOL |
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| Formula |
C19H16ClNO4
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| InChI |
InChI=1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)
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| InChIKey |
CGIGDMFJXJATDK-UHFFFAOYSA-N
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| CAS Number |
CAS 53-86-1
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| PubChem Compound ID | |||||
| PubChem Substance ID |
5032, 611045, 612102, 832223, 841055, 856012, 3225554, 5208606, 6435989, 7847209, 7888379, 7979604, 8027945, 8027950, 8027958, 8149387, 8152346, 10321568, 10525985, 11111328, 11111329, 11113361, 11121750, 11122230, 11335446, 11360685, 11362903, 11363813, 11365465, 11366375, 11368027, 11368937, 11370997, 11370998, 11371496, 11373534, 11373628, 11376189, 11377099, 11404374, 11446060, 11461657, 11466300, 11467420, 11484715, 11486099, 11488786, 11490284, 11491833, 11494733
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| ChEBI ID |
ChEBI:49662
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| SuperDrug ATC ID |
C01EB03; M01AB01; M02AA23; S01BC01
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| SuperDrug CAS ID |
cas=000053861
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| Target and Pathway | |||||
| Target(s) | Prostaglandin G/H synthase 2 | Target Info | Modulator | [2] | |
| BioCyc Pathway | Aspirin-triggered lipoxin biosynthesis | ||||
| Aspirin triggered resolvin D biosynthesis | |||||
| C20 prostanoid biosynthesis | |||||
| Aspirin triggered resolvin E biosynthesis | |||||
| KEGG Pathway | Arachidonic acid metabolism | ||||
| Metabolic pathways | |||||
| NF-kappa B signaling pathway | |||||
| VEGF signaling pathway | |||||
| TNF signaling pathway | |||||
| Retrograde endocannabinoid signaling | |||||
| Serotonergic synapse | |||||
| Ovarian steroidogenesis | |||||
| Oxytocin signaling pathway | |||||
| Regulation of lipolysis in adipocytes | |||||
| Leishmaniasis | |||||
| Pathways in cancer | |||||
| Chemical carcinogenesis | |||||
| MicroRNAs in cancer | |||||
| Small cell lung cancer | |||||
| NetPath Pathway | IL1 Signaling Pathway | ||||
| TSH Signaling Pathway | |||||
| IL4 Signaling Pathway | |||||
| TGF_beta_Receptor Signaling Pathway | |||||
| IL5 Signaling Pathway | |||||
| PANTHER Pathway | Endothelin signaling pathway | ||||
| Inflammation mediated by chemokine and cytokine signaling pathway | |||||
| Toll receptor signaling pathway | |||||
| CCKR signaling map ST | |||||
| Pathway Interaction Database | Calcineurin-regulated NFAT-dependent transcription in lymphocytes | ||||
| S1P1 pathway | |||||
| C-MYB transcription factor network | |||||
| Signaling mediated by p38-alpha and p38-beta | |||||
| Calcium signaling in the CD4+ TCR pathway | |||||
| PathWhiz Pathway | Arachidonic Acid Metabolism | ||||
| WikiPathways | Prostaglandin Synthesis and Regulation | ||||
| Arachidonic acid metabolism | |||||
| Aryl Hydrocarbon Receptor | |||||
| Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis | |||||
| Spinal Cord Injury | |||||
| Integrated Pancreatic Cancer Pathway | |||||
| Eicosanoid Synthesis | |||||
| Selenium Micronutrient Network | |||||
| References | |||||
| REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | ||||
| REF 2 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. | ||||
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