Drug Information
Drug General Information | |||||
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Drug ID |
D05RAB
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Former ID |
DNC011194
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Drug Name |
1,4-Dihydro-1-methyl-4-oxo-3-pyridinesulfonamide
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [530978] | ||
Structure |
Download2D MOL |
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Formula |
C6H8N2O3S
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Canonical SMILES |
CN1C=CC(=O)C(=C1)S(=O)(=O)N
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InChI |
1S/C6H8N2O3S/c1-8-3-2-5(9)6(4-8)12(7,10)11/h2-4H,1H3,(H2,7,10,11)
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InChIKey |
HTPSIFNKXNIAJZ-UHFFFAOYSA-N
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | Carbonic anhydrase IX | Target Info | Inhibitor | [530978] | |
Carbonic anhydrase I | Target Info | Inhibitor | [530978] | ||
Carbonic anhydrase XII | Target Info | Inhibitor | [530978] | ||
Carbonic anhydrase II | Target Info | Inhibitor | [530978] | ||
Pathway Interaction Database | HIF-1-alpha transcription factor networkcmyb_pathway:C-MYB transcription factor network | ||||
PathWhiz Pathway | Gastric Acid Production | ||||
Reactome | Regulation of gene expression by Hypoxia-inducible Factor | ||||
Reversible hydration of carbon dioxideR-HSA-1237044:Erythrocytes take up carbon dioxide and release oxygen | |||||
Erythrocytes take up oxygen and release carbon dioxide | |||||
Reversible hydration of carbon dioxideR-HSA-1475029:Reversible hydration of carbon dioxideR-HSA-1237044:Erythrocytes take up carbon dioxide and release oxygen | |||||
Reversible hydration of carbon dioxide | |||||
WikiPathways | Vitamin D Receptor Pathway | ||||
Reversible Hydration of Carbon Dioxide | |||||
Regulation of Hypoxia-inducible Factor (HIF) by OxygenWP2770:Reversible Hydration of Carbon Dioxide | |||||
Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes | |||||
Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP2770:Reversible Hydration of Carbon Dioxide | |||||
miR-targeted genes in muscle cell - TarBase | |||||
miR-targeted genes in leukocytes - TarBase | |||||
miR-targeted genes in epithelium - TarBaseWP2770:Reversible Hydration of Carbon Dioxide | |||||
Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes | |||||
References | |||||
Ref 530978 | Eur J Med Chem. 2010 Sep;45(9):3656-61. Epub 2010 May 12.Carbonic anhydrase inhibitors. Regioselective synthesis of novel 1-substituted 1,4-dihydro-4-oxo-3-pyridinesulfonamides and their inhibition of the human cytosolic isozymes I and II and transmembrane cancer-associated isozymes IX and XII. | ||||
Ref 530978 | Eur J Med Chem. 2010 Sep;45(9):3656-61. Epub 2010 May 12.Carbonic anhydrase inhibitors. Regioselective synthesis of novel 1-substituted 1,4-dihydro-4-oxo-3-pyridinesulfonamides and their inhibition of the human cytosolic isozymes I and II and transmembrane cancer-associated isozymes IX and XII. |
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