| Drug General Information |
| Drug ID |
D09UQM
|
| Former ID |
DNC006812
|
| Drug Name |
1-(3,4-dichlorophenyl)-3-hydroxyurea
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C7H6Cl2N2O2
|
| Canonical SMILES |
C1=CC(=C(C=C1NC(=O)NO)Cl)Cl
|
| InChI |
1S/C7H6Cl2N2O2/c8-5-2-1-4(3-6(5)9)10-7(12)11-13/h1-3,13H,(H2,10,11,12)
|
| InChIKey |
VKYZMAVGJARVPE-UHFFFAOYSA-N
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| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Carbonic anhydrase |
Target Info |
Inhibitor |
[1]
|
|---|
| Carbonic anhydrase IV |
Target Info |
Inhibitor |
[1]
|
| Carbonic anhydrase IX |
Target Info |
Inhibitor |
[1]
|
| Carbonic anhydrase II |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
Nitrogen metabolism
|
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Proximal tubule bicarbonate reclamationhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolism
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Proximal tubule bicarbonate reclamation
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Collecting duct acid secretion
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Gastric acid secretion
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Pancreatic secretion
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Bile secretion
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NetPath Pathway
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IL4 Signaling Pathway
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EGFR1 Signaling Pathway
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Pathway Interaction Database
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HIF-1-alpha transcription factor network
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Reactome
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Erythrocytes take up carbon dioxide and release oxygen
|
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Erythrocytes take up oxygen and release carbon dioxide
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Reversible hydration of carbon dioxideR-HSA-1234158:Regulation of gene expression by Hypoxia-inducible Factor
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Reversible hydration of carbon dioxideR-HSA-1237044:Erythrocytes take up carbon dioxide and release oxygen
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Reversible hydration of carbon dioxide
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WikiPathways
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Reversible Hydration of Carbon Dioxide
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Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
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Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP2877:Vitamin D Receptor Pathway
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Regulation of Hypoxia-inducible Factor (HIF) by OxygenWP2770:Reversible Hydration of Carbon Dioxide
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Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes
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| References |
| REF 1 | Bioorg Med Chem Lett. 2006 Aug 15;16(16):4316-20. Epub 2006 Jun 12.N-hydroxyurea--a versatile zinc binding function in the design of metalloenzyme inhibitors. |
|---|
