| Drug General Information |
| Drug ID |
D0Y3TZ
|
| Former ID |
DNC007143
|
| Drug Name |
GALLICACID
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C7H6O5
|
| InChI |
InChI=1S/C7H6O5/c8-4-1-3(7(11)12)2-5(9)6(4)10/h1-2,8-10H,(H,11,12)
|
| InChIKey |
LNTHITQWFMADLM-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
4609, 82806, 93480, 515619, 597137, 623400, 841193, 3139303, 6189885, 8001876, 8145227, 8150599, 10508685, 11341578, 11361761, 11363236, 11365798, 11368360, 11371268, 11375146, 11376522, 11484353, 11487163, 11488215, 11490070, 11493358, 11494156, 11537513, 12015396, 15219485, 17389871, 24438743, 24864730, 24895304, 25623933, 26613118, 26679367, 26747307, 26747308, 29204161, 47291482, 47589331, 48110832, 48413806, 48423452, 48425162, 49855037, 50105531, 50626002, 53787072
|
| Target and Pathway |
| Target(s) |
Carbonic anhydrase |
Target Info |
Inhibitor |
[2]
|
|---|
| Carbonic anhydrase IV |
Target Info |
Inhibitor |
[2]
|
| Carbonic anhydrase I |
Target Info |
Inhibitor |
[2]
|
| Carbonic anhydrase XIV |
Target Info |
Inhibitor |
[2]
|
| Carbonic anhydrase VI |
Target Info |
Inhibitor |
[2]
|
| P-selectin |
Target Info |
Inhibitor |
[3]
|
| Carbonic anhydrase IX |
Target Info |
Inhibitor |
[2]
|
| Carbonic anhydrase XII |
Target Info |
Inhibitor |
[2]
|
| Carbonic anhydrase II |
Target Info |
Inhibitor |
[2]
|
|
KEGG Pathway
|
Nitrogen metabolism
|
|
Proximal tubule bicarbonate reclamationhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolismhsa04514:Cell adhesion molecules (CAMs)
|
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Malaria
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Staphylococcus aureus infectionhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolism
|
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Proximal tubule bicarbonate reclamation
|
|
Collecting duct acid secretion
|
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Gastric acid secretion
|
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Pancreatic secretion
|
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Bile secretion
|
|
NetPath Pathway
|
TGF_beta_Receptor Signaling PathwayNetPath_16:IL4 Signaling Pathway
|
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EGFR1 Signaling Pathway
|
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Pathway Interaction Database
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C-MYB transcription factor networkil4_2pathway:IL4-mediated signaling events
|
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amb2 Integrin signalinghif1_tfpathway:HIF-1-alpha transcription factor network
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PathWhiz Pathway
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Gastric Acid Production
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|
Reactome
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Erythrocytes take up carbon dioxide and release oxygen
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Erythrocytes take up oxygen and release carbon dioxide
|
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Reversible hydration of carbon dioxideR-HSA-1237044:Erythrocytes take up carbon dioxide and release oxygen
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Reversible hydration of carbon dioxideR-HSA-1475029:Reversible hydration of carbon dioxideR-HSA-1475029:Reversible hydration of carbon dioxideR-HSA-114608:Platelet degranulation
|
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Cell surface interactions at the vascular wallR-HSA-1234158:Regulation of gene expression by Hypoxia-inducible Factor
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Reversible hydration of carbon dioxideR-HSA-1475029:Reversible hydration of carbon dioxideR-HSA-1237044:Erythrocytes take up carbon dioxide and release oxygen
|
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Reversible hydration of carbon dioxide
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WikiPathways
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Reversible Hydration of Carbon Dioxide
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Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
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Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP2770:Reversible Hydration of Carbon Dioxide
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Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP2770:Reversible Hydration of Carbon DioxideWP2770:Reversible Hydration of Carbon DioxideWP2806:Human Complement System
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Spinal Cord Injury
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Cell surface interactions at the vascular wallWP2877:Vitamin D Receptor Pathway
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Regulation of Hypoxia-inducible Factor (HIF) by OxygenWP2770:Reversible Hydration of Carbon Dioxide
|
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miR-targeted genes in muscle cell - TarBase
|
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miR-targeted genes in leukocytes - TarBase
|
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miR-targeted genes in epithelium - TarBaseWP2770:Reversible Hydration of Carbon Dioxide
|
|
Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes
|
| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5549). |
|---|
| REF 2 | Bioorg Med Chem. 2010 Mar 15;18(6):2159-64. Epub 2010 Feb 6.Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. |
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| REF 3 | J Med Chem. 2007 Mar 22;50(6):1101-15. Epub 2007 Feb 16.Rational design of novel, potent small molecule pan-selectin antagonists. |
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