Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D00XIB
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| Former ID |
DNC005130
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| Drug Name |
1-acetamido-5-sulfonamidoindane
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| Synonyms |
N-(5-Sulfamoyl-indan-1-yl)-acetamide
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| Indication | Discovery agent | Investigative | [528160] | ||
| Structure |
|
Download2D MOL |
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| Canonical SMILES |
CC(=O)NC1CCC2=C1C=CC(=C2)S(=O)(=O)N
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| InChI |
1S/C11H14N2O3S/c1-7(14)13-11-5-2-8-6-9(17(12,15)16)3-4-10(8)11/h3-4,6,11H,2,5H2,1H3,(H,13,14)(H2,12,15,16)
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| InChIKey |
RUUYVLNZHGCPRP-UHFFFAOYSA-N
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| Target and Pathway | |||||
| Target(s) | Carbonic anhydrase I | Target Info | Inhibitor | [527262] | |
| Carbonic anhydrase II | Target Info | Inhibitor | [528160] | ||
| Carbonic anhydrase IX | Target Info | Inhibitor | [528160] | ||
| NetPath Pathway | IL4 Signaling Pathway | ||||
| EGFR1 Signaling Pathway | |||||
| Pathway Interaction Database | C-MYB transcription factor networkhif1_tfpathway:HIF-1-alpha transcription factor network | ||||
| PathWhiz Pathway | Gastric Acid Production | ||||
| Reactome | Erythrocytes take up carbon dioxide and release oxygen | ||||
| Erythrocytes take up oxygen and release carbon dioxide | |||||
| Reversible hydration of carbon dioxideR-HSA-1237044:Erythrocytes take up carbon dioxide and release oxygen | |||||
| Reversible hydration of carbon dioxideR-HSA-1234158:Regulation of gene expression by Hypoxia-inducible Factor | |||||
| Reversible hydration of carbon dioxide | |||||
| WikiPathways | Reversible Hydration of Carbon Dioxide | ||||
| Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes | |||||
| Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP2770:Reversible Hydration of Carbon Dioxide | |||||
| Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP2877:Vitamin D Receptor Pathway | |||||
| Regulation of Hypoxia-inducible Factor (HIF) by Oxygen | |||||
| References | |||||
| Ref 527262 | Bioorg Med Chem Lett. 2004 Dec 6;14(23):5781-6.Carbonic anhydrase inhibitors. Design of anticonvulsant sulfonamides incorporating indane moieties. | ||||
| Ref 528160 | J Med Chem. 2006 May 4;49(9):2743-9.Indanesulfonamides as carbonic anhydrase inhibitors. Toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX. | ||||
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