Drug General Information
Drug ID	D09OSN
Former ID	DNC009810
Drug Name	Biphenyl-4-ylboronic acid
Synonyms	Biphenylboronic acid
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[530086]
Structure		Download 2D MOL 3D MOL
Formula	C12H11BO2
PubChem Compound ID	151253
Target and Pathway
Target(s)	Carbonic anhydrase I	Target Info	Inhibitor	[530086]
	Carbonic anhydrase	Target Info	Inhibitor	[530086]
	Fatty-acid amide hydrolase	Target Info	Inhibitor	[529790]
	Carbonic anhydrase II	Target Info	Inhibitor	[530086]
BioCyc Pathway	Anandamide degradation
KEGG Pathway	Nitrogen metabolismhsa04723:Retrograde endocannabinoid signalinghsa00910:Nitrogen metabolism
	Proximal tubule bicarbonate reclamation
	Collecting duct acid secretion
	Gastric acid secretion
	Pancreatic secretion
	Bile secretion
NetPath Pathway	IL4 Signaling Pathway
	EGFR1 Signaling Pathway
PANTHER Pathway	Anandamide degradation
Pathway Interaction Database	C-MYB transcription factor network
PathWhiz Pathway	Gastric Acid Production
Reactome	Erythrocytes take up carbon dioxide and release oxygen
	Erythrocytes take up oxygen and release carbon dioxide
	Reversible hydration of carbon dioxideR-HSA-1237044:Erythrocytes take up carbon dioxide and release oxygen
	Reversible hydration of carbon dioxide
WikiPathways	Reversible Hydration of Carbon Dioxide
	Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
	Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP2770:Reversible Hydration of Carbon Dioxide
	Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes
References
Ref 530086	Bioorg Med Chem Lett. 2009 May 15;19(10):2642-5. Epub 2009 Apr 5.Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids.
Ref 529790	J Med Chem. 2008 Nov 27;51(22):7057-60.Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase.
Ref 530086	Bioorg Med Chem Lett. 2009 May 15;19(10):2642-5. Epub 2009 Apr 5.Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids.

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