Drug Information

Drug General Information
Drug ID
D0G0OP
Former ID
DNC007389
Drug Name
2-(4-chlorobenzyloxyamino)-N-hydroxypropanamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528653]
Structure
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2D MOL

3D MOL
Formula
C10H13ClN2O3
Canonical SMILES
CC(C(=O)NO)NOCC1=CC=C(C=C1)Cl
InChI
1S/C10H13ClN2O3/c1-7(10(14)12-15)13-16-6-8-2-4-9(11)5-3-8/h2-5,7,13,15H,6H2,1H3,(H,12,14)
InChIKey
JNDVWCINXNIDOF-UHFFFAOYSA-N
PubChem Compound ID
44423685
Target and Pathway
Target(s) Carbonic anhydrase IX Target Info Inhibitor [528653]
Carbonic anhydrase II Target Info Inhibitor [528653]
Carbonic anhydrase I Target Info Inhibitor [528653]
KEGG Pathway Nitrogen metabolismhsa00910:Nitrogen metabolism
Proximal tubule bicarbonate reclamation
Collecting duct acid secretion
Gastric acid secretion
Pancreatic secretion
Bile secretionhsa00910:Nitrogen metabolism
NetPath Pathway IL4 Signaling Pathway
EGFR1 Signaling Pathway
Pathway Interaction Database HIF-1-alpha transcription factor networkcmyb_pathway:C-MYB transcription factor network
PathWhiz Pathway Gastric Acid Production
Reactome Regulation of gene expression by Hypoxia-inducible Factor
Reversible hydration of carbon dioxideR-HSA-1237044:Erythrocytes take up carbon dioxide and release oxygen
Erythrocytes take up oxygen and release carbon dioxide
Reversible hydration of carbon dioxide
WikiPathways Vitamin D Receptor Pathway
Reversible Hydration of Carbon Dioxide
Regulation of Hypoxia-inducible Factor (HIF) by OxygenWP2770:Reversible Hydration of Carbon Dioxide
Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP2770:Reversible Hydration of Carbon Dioxide
Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes
References
Ref 528653Bioorg Med Chem. 2007 Mar 15;15(6):2298-311. Epub 2007 Jan 19.Carbonic anhydrase and matrix metalloproteinase inhibitors. Inhibition of human tumor-associated isozymes IX and cytosolic isozyme I andII with sulfonylated hydroxamates.
Ref 528653Bioorg Med Chem. 2007 Mar 15;15(6):2298-311. Epub 2007 Jan 19.Carbonic anhydrase and matrix metalloproteinase inhibitors. Inhibition of human tumor-associated isozymes IX and cytosolic isozyme I andII with sulfonylated hydroxamates.

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