| Drug General Information |
| Drug ID |
D0PA5L
|
| Former ID |
DNC005675
|
| Drug Name |
N-(pentafluorophenyl)sulfamide
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C6H3F5N2O2S
|
| Canonical SMILES |
C1(=C(C(=C(C(=C1F)F)F)F)F)NS(=O)(=O)N
|
| InChI |
1S/C6H3F5N2O2S/c7-1-2(8)4(10)6(5(11)3(1)9)13-16(12,14)15/h13H,(H2,12,14,15)
|
| InChIKey |
UPYNRFQXRYOBBD-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Carbonic anhydrase I |
Target Info |
Inhibitor |
[1]
|
|---|
| Carbonic anhydrase XII |
Target Info |
Inhibitor |
[1]
|
| Carbonic anhydrase II |
Target Info |
Inhibitor |
[1]
|
| Carbonic anhydrase IX |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
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Nitrogen metabolismhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolism
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Proximal tubule bicarbonate reclamation
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Collecting duct acid secretion
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Gastric acid secretion
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Pancreatic secretion
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Bile secretionhsa00910:Nitrogen metabolism
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NetPath Pathway
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TGF_beta_Receptor Signaling PathwayNetPath_16:IL4 Signaling Pathway
|
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EGFR1 Signaling Pathway
|
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Pathway Interaction Database
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C-MYB transcription factor networkhif1_tfpathway:HIF-1-alpha transcription factor network
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PathWhiz Pathway
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Gastric Acid Production
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Reactome
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Erythrocytes take up carbon dioxide and release oxygen
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Erythrocytes take up oxygen and release carbon dioxide
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Reversible hydration of carbon dioxideR-HSA-1475029:Reversible hydration of carbon dioxideR-HSA-1237044:Erythrocytes take up carbon dioxide and release oxygen
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Reversible hydration of carbon dioxideR-HSA-1234158:Regulation of gene expression by Hypoxia-inducible Factor
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Reversible hydration of carbon dioxide
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WikiPathways
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Reversible Hydration of Carbon Dioxide
|
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Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
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Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP2770:Reversible Hydration of Carbon Dioxide
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miR-targeted genes in muscle cell - TarBase
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miR-targeted genes in leukocytes - TarBase
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miR-targeted genes in epithelium - TarBaseWP2770:Reversible Hydration of Carbon Dioxide
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Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP2877:Vitamin D Receptor Pathway
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Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
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| References |
| REF 1 | Bioorg Med Chem Lett. 2005 May 2;15(9):2353-8.Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with N-hydroxysulfamides--a new zinc-binding function in the design of inhibitors. |
|---|
