Drug General Information
Drug ID	D0N1AW
Former ID	DNC010072
Drug Name	6-(aminomethyl)-2H-chromen-2-one
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[530514]
Structure		Download 2D MOL 3D MOL
Formula	C10H9NO2
Canonical SMILES	C1=CC2=C(C=CC(=O)O2)C=C1CN
InChI	1S/C10H9NO2/c11-6-7-1-3-9-8(5-7)2-4-10(12)13-9/h1-5H,6,11H2
InChIKey	MXXNUQUOHJMQEU-UHFFFAOYSA-N
PubChem Compound ID	45485270
Target and Pathway
Target(s)	Carbonic anhydrase XII	Target Info	Inhibitor	[530514]
	Carbonic anhydrase II	Target Info	Inhibitor	[530514]
	Carbonic anhydrase XIV	Target Info	Inhibitor	[530514]
	Carbonic anhydrase VI	Target Info	Inhibitor	[530514]
	Carbonic anhydrase IX	Target Info	Inhibitor	[530514]
	Carbonic anhydrase I	Target Info	Inhibitor	[530514]
	Carbonic anhydrase IV	Target Info	Inhibitor	[530514]
	Carbonic anhydrase	Target Info	Inhibitor	[530514]
KEGG Pathway	Nitrogen metabolismhsa00910:Nitrogen metabolism
	Proximal tubule bicarbonate reclamation
	Collecting duct acid secretion
	Gastric acid secretion
	Pancreatic secretion
	Bile secretionhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolism
NetPath Pathway	TGF_beta_Receptor Signaling PathwayNetPath_16:IL4 Signaling Pathway
	EGFR1 Signaling Pathway
Pathway Interaction Database	HIF-1-alpha transcription factor networkcmyb_pathway:C-MYB transcription factor network
PathWhiz Pathway	Gastric Acid Production
Reactome	Reversible hydration of carbon dioxideR-HSA-1237044:Erythrocytes take up carbon dioxide and release oxygen
	Erythrocytes take up oxygen and release carbon dioxide
	Reversible hydration of carbon dioxideR-HSA-1475029:Reversible hydration of carbon dioxideR-HSA-1475029:Reversible hydration of carbon dioxideR-HSA-1234158:Regulation of gene expression by Hypoxia-inducible Factor
	Reversible hydration of carbon dioxide
WikiPathways	Reversible Hydration of Carbon Dioxide
	miR-targeted genes in muscle cell - TarBase
	miR-targeted genes in leukocytes - TarBase
	miR-targeted genes in epithelium - TarBaseWP2770:Reversible Hydration of Carbon Dioxide
	Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
	Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP2770:Reversible Hydration of Carbon DioxideWP2770:Reversible Hydration of Carbon DioxideWP2877:Vitamin D Receptor Pathway
	Regulation of Hypoxia-inducible Factor (HIF) by OxygenWP2770:Reversible Hydration of Carbon Dioxide
	Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP2770:Reversible Hydration of Carbon Dioxide
	Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes
References
Ref 530514	J Med Chem. 2010 Jan 14;53(1):335-44.Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins.
Ref 530514	J Med Chem. 2010 Jan 14;53(1):335-44.Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins.

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