| Drug General Information |
| Drug ID |
D09CXX
|
| Former ID |
DNC010904
|
| Drug Name |
N-hydroxysulfamide
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
H4N2O3S
|
| Canonical SMILES |
NS(=O)(=O)NO
|
| InChI |
1S/H4N2O3S/c1-6(4,5)2-3/h2-3H,(H2,1,4,5)
|
| InChIKey |
FZTCJYJKHSXPEX-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Carbonic anhydrase IX |
Target Info |
Inhibitor |
[1]
|
|---|
| Carbonic anhydrase II |
Target Info |
Inhibitor |
[1]
|
| Carbonic anhydrase XII |
Target Info |
Inhibitor |
[1]
|
| Carbonic anhydrase I |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
Nitrogen metabolismhsa00910:Nitrogen metabolism
|
|
Proximal tubule bicarbonate reclamation
|
|
Collecting duct acid secretion
|
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Gastric acid secretion
|
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Pancreatic secretion
|
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Bile secretionhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolism
|
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NetPath Pathway
|
IL4 Signaling Pathway
|
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EGFR1 Signaling PathwayNetPath_7:TGF_beta_Receptor Signaling Pathway
|
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Pathway Interaction Database
|
HIF-1-alpha transcription factor networkcmyb_pathway:C-MYB transcription factor network
|
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PathWhiz Pathway
|
Gastric Acid Production
|
|
Reactome
|
Regulation of gene expression by Hypoxia-inducible Factor
|
|
Reversible hydration of carbon dioxideR-HSA-1237044:Erythrocytes take up carbon dioxide and release oxygen
|
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Erythrocytes take up oxygen and release carbon dioxide
|
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Reversible hydration of carbon dioxideR-HSA-1475029:Reversible hydration of carbon dioxideR-HSA-1237044:Erythrocytes take up carbon dioxide and release oxygen
|
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Reversible hydration of carbon dioxide
|
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WikiPathways
|
Vitamin D Receptor Pathway
|
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Reversible Hydration of Carbon Dioxide
|
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Regulation of Hypoxia-inducible Factor (HIF) by OxygenWP2770:Reversible Hydration of Carbon Dioxide
|
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Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
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Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP2770:Reversible Hydration of Carbon Dioxide
|
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miR-targeted genes in muscle cell - TarBase
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miR-targeted genes in leukocytes - TarBase
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miR-targeted genes in epithelium - TarBaseWP2770:Reversible Hydration of Carbon Dioxide
|
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Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes
|
| References |
| REF 1 | Bioorg Med Chem Lett. 2010 Jun 15;20(12):3601-5. Epub 2010 Apr 28.Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV. |
|---|
