Drug General Information
Drug ID	D0A8JP
Former ID	DNC008509
Drug Name	PARABEN
Indication	Discovery agent		Phase 3	[524059]
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	Carbonic anhydrase XIV	Target Info	Inhibitor	[530751]
	Carbonic anhydrase VI	Target Info	Inhibitor	[530751]
	Carbonic anhydrase IX	Target Info	Inhibitor	[530751]
	Carbonic anhydrase XII	Target Info	Inhibitor	[530751]
	Carbonic anhydrase II	Target Info	Inhibitor	[530751]
	Carbonic anhydrase	Target Info	Inhibitor	[530751]
	Carbonic anhydrase IV	Target Info	Inhibitor	[530751]
	Carbonic anhydrase I	Target Info	Inhibitor	[530751]
KEGG Pathway	Nitrogen metabolismhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolism
	Proximal tubule bicarbonate reclamation
	Collecting duct acid secretion
	Gastric acid secretion
	Pancreatic secretion
	Bile secretionhsa00910:Nitrogen metabolism
	Proximal tubule bicarbonate reclamationhsa00910:Nitrogen metabolism
NetPath Pathway	TGF_beta_Receptor Signaling PathwayNetPath_16:IL4 Signaling Pathway
	EGFR1 Signaling Pathway
Pathway Interaction Database	HIF-1-alpha transcription factor networkcmyb_pathway:C-MYB transcription factor network
PathWhiz Pathway	Gastric Acid Production
Reactome	Reversible hydration of carbon dioxideR-HSA-1475029:Reversible hydration of carbon dioxideR-HSA-1234158:Regulation of gene expression by Hypoxia-inducible Factor
	Reversible hydration of carbon dioxideR-HSA-1475029:Reversible hydration of carbon dioxideR-HSA-1237044:Erythrocytes take up carbon dioxide and release oxygen
	Erythrocytes take up oxygen and release carbon dioxide
	Reversible hydration of carbon dioxideR-HSA-1237044:Erythrocytes take up carbon dioxide and release oxygen
	Reversible hydration of carbon dioxide
WikiPathways	Reversible Hydration of Carbon DioxideWP2770:Reversible Hydration of Carbon DioxideWP2877:Vitamin D Receptor Pathway
	Reversible Hydration of Carbon Dioxide
	Regulation of Hypoxia-inducible Factor (HIF) by OxygenWP2770:Reversible Hydration of Carbon Dioxide
	miR-targeted genes in muscle cell - TarBase
	miR-targeted genes in leukocytes - TarBase
	miR-targeted genes in epithelium - TarBaseWP2770:Reversible Hydration of Carbon Dioxide
	Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
	Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP2770:Reversible Hydration of Carbon Dioxide
	Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes
References
Ref 524059	ClinicalTrials.gov (NCT01688479) Trial Comparing Calendula Officinalis With Aqueous Cream "Essex" to Treat Skin Reactions From Radiotherapy of Breast Cancer. U.S. National Institutes of Health.
Ref 530751	Bioorg Med Chem. 2010 Mar 15;18(6):2159-64. Epub 2010 Feb 6.Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids.

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