| Drug General Information |
| Drug ID |
D03VUQ
|
| Former ID |
DNC008213
|
| Drug Name |
4-(4-hydroxy-benzylideneamino)-benzenesulfonamide
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| Synonyms |
4-(4-hydroxybenzylideneamino)benzenesulfonamide
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| Indication |
Discovery agent
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Investigative |
[1]
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| Structure |
|
Download
2D MOL
3D MOL
|
| Canonical SMILES |
C1=CC(=O)C=CC1=CNC2=CC=C(C=C2)S(=O)(=O)N
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| InChI |
1S/C13H12N2O3S/c14-19(17,18)13-7-3-11(4-8-13)15-9-10-1-5-12(16)6-2-10/h1-9,15H,(H2,14,17,18)
|
| InChIKey |
QNCWACMNLQTFIY-UHFFFAOYSA-N
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| Target and Pathway |
| Target(s) |
Carbonic anhydrase II |
Target Info |
Inhibitor |
[2]
|
|---|
| Prostaglandin G/H synthase 2 |
Target Info |
Inhibitor |
[1]
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BioCyc Pathway
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Aspirin-triggered lipoxin biosynthesis
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Aspirin triggered resolvin D biosynthesis
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C20 prostanoid biosynthesis
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Aspirin triggered resolvin E biosynthesis
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KEGG Pathway
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Nitrogen metabolism
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Proximal tubule bicarbonate reclamation
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Collecting duct acid secretion
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Gastric acid secretion
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Pancreatic secretion
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Bile secretionhsa00590:Arachidonic acid metabolism
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Metabolic pathways
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NF-kappa B signaling pathway
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VEGF signaling pathway
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TNF signaling pathway
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Retrograde endocannabinoid signaling
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Serotonergic synapse
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Ovarian steroidogenesis
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Oxytocin signaling pathway
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Regulation of lipolysis in adipocytes
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Leishmaniasis
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Pathways in cancer
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Chemical carcinogenesis
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MicroRNAs in cancer
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Small cell lung cancer
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NetPath Pathway
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IL4 Signaling Pathway
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EGFR1 Signaling PathwayNetPath_13:IL1 Signaling Pathway
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TSH Signaling Pathway
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TGF_beta_Receptor Signaling Pathway
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IL5 Signaling Pathway
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PANTHER Pathway
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Endothelin signaling pathway
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Inflammation mediated by chemokine and cytokine signaling pathway
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Toll receptor signaling pathway
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CCKR signaling map ST
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Pathway Interaction Database
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Calcineurin-regulated NFAT-dependent transcription in lymphocytes
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S1P1 pathway
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C-MYB transcription factor network
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Signaling mediated by p38-alpha and p38-beta
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Calcium signaling in the CD4+ TCR pathway
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PathWhiz Pathway
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Arachidonic Acid Metabolism
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Reactome
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Erythrocytes take up carbon dioxide and release oxygen
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Erythrocytes take up oxygen and release carbon dioxide
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Reversible hydration of carbon dioxide
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WikiPathways
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Reversible Hydration of Carbon Dioxide
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Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
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Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP98:Prostaglandin Synthesis and Regulation
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Arachidonic acid metabolism
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Aryl Hydrocarbon Receptor
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Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
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Spinal Cord Injury
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Integrated Pancreatic Cancer Pathway
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Eicosanoid Synthesis
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Selenium Micronutrient Network
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| References |
| REF 1 | Bioorg Med Chem. 2008 Mar 1;16(5):2697-706. Epub 2007 Nov 17.Selective COX-2 inhibitors. Part 2: synthesis and biological evaluation of 4-benzylideneamino- and 4-phenyliminomethyl-benzenesulfonamides. |
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| REF 2 | Bioorg Med Chem Lett. 2009 Nov 1;19(21):6014-7. Epub 2009 Sep 17.Carbonic anhydrase II-induced selection of inhibitors from a dynamic combinatorial library of Schiff's bases. |
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