| Drug General Information |
| Drug ID |
D06IOI
|
| Former ID |
DNC010952
|
| Drug Name |
4-Benzythiopyridine-3-sulfonamide
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C12H12N2O2S2
|
| Canonical SMILES |
C1=CC=C(C=C1)CSC2=C(C=NC=C2)S(=O)(=O)N
|
| InChI |
1S/C12H12N2O2S2/c13-18(15,16)12-8-14-7-6-11(12)17-9-10-4-2-1-3-5-10/h1-8H,9H2,(H2,13,15,16)
|
| InChIKey |
FUJBJSOIYVUFSM-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Carbonic anhydrase IX |
Target Info |
Inhibitor |
[1]
|
|---|
| Carbonic anhydrase XIV |
Target Info |
Inhibitor |
[1]
|
| Carbonic anhydrase II |
Target Info |
Inhibitor |
[1]
|
| Carbonic anhydrase XII |
Target Info |
Inhibitor |
[1]
|
| Carbonic anhydrase I |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
Nitrogen metabolismhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolism
|
|
Proximal tubule bicarbonate reclamation
|
|
Collecting duct acid secretion
|
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Gastric acid secretion
|
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Pancreatic secretion
|
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Bile secretionhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolism
|
|
NetPath Pathway
|
IL4 Signaling Pathway
|
|
EGFR1 Signaling PathwayNetPath_7:TGF_beta_Receptor Signaling Pathway
|
|
Pathway Interaction Database
|
HIF-1-alpha transcription factor networkcmyb_pathway:C-MYB transcription factor network
|
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PathWhiz Pathway
|
Gastric Acid Production
|
|
Reactome
|
Regulation of gene expression by Hypoxia-inducible Factor
|
|
Reversible hydration of carbon dioxideR-HSA-1475029:Reversible hydration of carbon dioxideR-HSA-1237044:Erythrocytes take up carbon dioxide and release oxygen
|
|
Erythrocytes take up oxygen and release carbon dioxide
|
|
Reversible hydration of carbon dioxide
|
|
WikiPathways
|
Vitamin D Receptor Pathway
|
|
Reversible Hydration of Carbon Dioxide
|
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Regulation of Hypoxia-inducible Factor (HIF) by OxygenWP2770:Reversible Hydration of Carbon DioxideWP2770:Reversible Hydration of Carbon Dioxide
|
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Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
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Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP2770:Reversible Hydration of Carbon Dioxide
|
|
miR-targeted genes in muscle cell - TarBase
|
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miR-targeted genes in leukocytes - TarBase
|
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miR-targeted genes in epithelium - TarBaseWP2770:Reversible Hydration of Carbon Dioxide
|
|
Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes
|
| References |
| REF 1 | Eur J Med Chem. 2010 Jun;45(6):2396-404. Epub 2010 Feb 12.Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with 4-substituted 3-pyridinesulfonamides. |
|---|
