Drug Information

Drug General Information
Drug ID
D0E3VJ
Former ID
DNC009405
Drug Name
N-[5-(ethylthio)-1,3,4-thiadiazol-2-yl]sulfamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529794]
Structure
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2D MOL

3D MOL
Formula
C4H8N4O2S3
Canonical SMILES
CCSC1=NN=C(S1)NS(=O)(=O)N
InChI
1S/C4H8N4O2S3/c1-2-11-4-7-6-3(12-4)8-13(5,9)10/h2H2,1H3,(H,6,8)(H2,5,9,10)
InChIKey
CHUOTDNKSODBJL-UHFFFAOYSA-N
PubChem Compound ID
25154731
Target and Pathway
Target(s) Carbonic anhydrase I Target Info Inhibitor [529794]
Carbonic anhydrase IV Target Info Inhibitor [529794]
Carbonic anhydrase Target Info Inhibitor [529794]
Carbonic anhydrase II Target Info Inhibitor [529794]
KEGG Pathway Nitrogen metabolismhsa00910:Nitrogen metabolism
Proximal tubule bicarbonate reclamationhsa00910:Nitrogen metabolism
Proximal tubule bicarbonate reclamation
Collecting duct acid secretion
Gastric acid secretion
Pancreatic secretion
Bile secretion
NetPath Pathway IL4 Signaling Pathway
EGFR1 Signaling Pathway
Pathway Interaction Database C-MYB transcription factor network
PathWhiz Pathway Gastric Acid Production
Reactome Erythrocytes take up carbon dioxide and release oxygen
Erythrocytes take up oxygen and release carbon dioxide
Reversible hydration of carbon dioxideR-HSA-1237044:Erythrocytes take up carbon dioxide and release oxygen
Reversible hydration of carbon dioxide
WikiPathways Reversible Hydration of Carbon Dioxide
Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP2770:Reversible Hydration of Carbon Dioxide
Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes
References
Ref 529794Bioorg Med Chem Lett. 2008 Dec 15;18(24):6332-5. Epub 2008 Nov 1.Carbonic anhydrase inhibitors: 2-substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes VA and VB over the cytosolic and membrane-associated carbonic anhydrases I, II and IV.
Ref 529794Bioorg Med Chem Lett. 2008 Dec 15;18(24):6332-5. Epub 2008 Nov 1.Carbonic anhydrase inhibitors: 2-substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes VA and VB over the cytosolic and membrane-associated carbonic anhydrases I, II and IV.

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