Target Information
Target General Infomation | |||||
---|---|---|---|---|---|
Target ID |
T78709
|
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Former ID |
TTDS00098
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Target Name |
5-hydroxytryptamine 1A receptor
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Gene Name |
HTR1A
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Synonyms |
5-HT-1A; 5-HT1A; 5-HT1A receptor; 5-hydroxytryptamine receptor 1A; G-21; Serotonin receptor; Serotonin receptor 1A; HTR1A
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Target Type |
Successful
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Disease | Alzheimer disease; Peripheral sensory neuropathies; Lateral sclerosis [ICD9:331.0, 356.0, 356.8; ICD10: G30, G64, G90.0, G12.2] | ||||
Alzheimer disease [ICD9: 331; ICD10: G30] | |||||
Addiction [ICD code not available] | |||||
Aggressive non-hodgkin's lymphoma [ICD9: 200, 201, 202, 202.8, 208.9; ICD10: C81, C81-C86, C82-C85, C91-C95] | |||||
Anxiety disorder [ICD9: 300, 311; ICD10: F32, F40-F42] | |||||
Bulimia nervosa; Severe mood disorders [ICD9: 296, 307.51; ICD10: F30-F39, F50.2] | |||||
Cognitive disorders [ICD9: 290-294, 294.0, 780.09, 780.9, 780.93; ICD10: F01-F07, F04, F05, R41.3] | |||||
Coronary artery disease [ICD9: 410-414, 429.2; ICD10: I20-I25] | |||||
Cervical dystonia; Spasm [ICD9:333.83, 728.85; ICD10: G24.3, R25.2] | |||||
Depression [ICD9: 311; ICD10: F30-F39] | |||||
Eating disorder [ICD9: 278, 307.5, 401, 428.0; ICD10: E66, F50, I10-I16, I50] | |||||
Female sexual dysfunction [ICD9: 302.7; ICD10: F52] | |||||
Generalized anxiety disorder [ICD9: 300, 300.02, 311; ICD10: F32, F40-F42, F41.1] | |||||
Generalized anxiety disorder; Social phobia [ICD9: 300, 300.02, 300.23; ICD10: F40-F42, F40.1, F41.1, F93.2] | |||||
Hypoactive sexual desire disorder [ICD10: F52.0] | |||||
Hypertension [ICD9: 401; ICD10: I10-I16] | |||||
Insomnia [ICD9: 307.41, 307.42, 327.0, 780.51, 780.52; ICD10: F51.0, G47.0] | |||||
Mood disorder [ICD10: F30-F39] | |||||
Migraine [ICD9: 346; ICD10: G43] | |||||
Major depressive disorder; Episode; Anxiety [ICD9: 296.2, 296.3, 300; ICD10: F32, F32.2, F32.3, F33, F40-F42] | |||||
Major depressive disorder [ICD9: 296.2, 296.3, 710.0; ICD10: F32, F33, M32] | |||||
Psychiatric disorder [ICD9: 290-319; ICD10: F01-F99] | |||||
Parkinson's disease [ICD9: 332; ICD10: G20] | |||||
Psychotic disorders [ICD9: 290-299; ICD10: F20-F29] | |||||
Premature ejaculation [ICD9: 302.75; ICD10: F52.4] | |||||
Post-traumatic stress disorder [ICD9: 309.81; ICD10: F43.1] | |||||
Pain [ICD9: 338, 356.0, 356.8,780; ICD10: G64, G90.0, R52, G89] | |||||
Schizophrenia [ICD9: 295; ICD10: F20] | |||||
Severe mood disorders [ICD9: 296; ICD10: F30-F39] | |||||
Schizoaffective disorder; Schizophrenia [ICD9: 295, 295.70; ICD10: F20, F25] | |||||
Urinary incontinence [ICD9: 788.3; ICD10: N39.3, N39.4, R32] | |||||
Unspecified [ICD code not available] | |||||
Function |
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5- hydroxytryptamine release and in the regulation of dopamine and 5- hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli.
|
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BioChemical Class |
GPCR rhodopsin
|
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Target Validation |
T78709
|
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UniProt ID | |||||
Sequence |
MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAA
IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED RSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADT RHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGN SKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLP FFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC RQ |
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Drugs and Mode of Action | |||||
Drug(s) | Buspirone | Drug Info | Approved | Anxiety disorder | [536505], [540478] |
Flibanserin | Drug Info | Approved | Mood disorder | [532651], [542987] | |
OPC-34712 | Drug Info | Approved | Major depressive disorder | [523551], [542651] | |
TERTATOLOL | Drug Info | Approved | Hypertension | [541537], [551871] | |
Trazodone | Drug Info | Approved | Depression | [536306], [539351] | |
Treximet | Drug Info | Approved | Migraine | [538578] | |
Urapidil | Drug Info | Approved | Hypertension | [551871] | |
Vilazodone | Drug Info | Approved | Major depressive disorder | [531783], [542450] | |
CM-2395 | Drug Info | Phase 3 | Schizophrenia | [551513] | |
Flibanserin | Drug Info | Phase 3 | Female sexual dysfunction | [536493], [542987] | |
LECOZOTAN HYDROCHLORIDE | Drug Info | Phase 2/3 | Cognitive disorders | [521788] | |
Eltoprazine | Drug Info | Phase 2 | Aggressive non-hodgkin's lymphoma | [523309] | |
Ensaculin hydrochloride | Drug Info | Phase 2 | Parkinson's disease | [526403] | |
Mazapertine succinate | Drug Info | Phase 2 | Psychotic disorders | [534644] | |
MIN-117 | Drug Info | Phase 2 | Major depressive disorder | [549451] | |
MN-305 | Drug Info | Phase 2 | Severe mood disorders | [536580] | |
Neu-P11 | Drug Info | Phase 2 | Insomnia | [523722] | |
OPC-14523 | Drug Info | Phase 2 | Bulimia nervosa; Severe mood disorders | [536493] | |
ORG-13011 | Drug Info | Phase 2 | Psychotic disorders | [521409] | |
RP5063 | Drug Info | Phase 2 | Schizoaffective disorder; Schizophrenia | [523723] | |
S-15535 | Drug Info | Phase 2 | Anxiety disorder | [539677], [545119] | |
S-16924 | Drug Info | Phase 2 | Anxiety disorder | [525424], [534704], [539033] | |
SDZ-MAR-327 | Drug Info | Phase 2 | Psychotic disorders | [534772], [536463] | |
SUN N4057 | Drug Info | Phase 2 | Coronary artery disease | [521780] | |
TGBA01AD | Drug Info | Phase 2 | Severe mood disorders | [536580] | |
TGFK08AA-ER | Drug Info | Phase 2 | Generalized anxiety disorder | [550644] | |
TGFK09SD-ER | Drug Info | Phase 2 | Hypoactive sexual desire disorder | [550647] | |
TGWOOAA | Drug Info | Phase 2 | Generalized anxiety disorder; Social phobia | [550646] | |
Zalospirone | Drug Info | Phase 2 | Anxiety disorder | [533189], [541119] | |
1192U90 | Drug Info | Phase 1 | Psychotic disorders | [534252] | |
AV-965 | Drug Info | Phase 1 | Alzheimer disease | [548413] | |
DSP-1053 | Drug Info | Phase 1 | Major depressive disorder | [524195] | |
GSK-958108 | Drug Info | Phase 1 | Premature ejaculation | [522300] | |
OPC-14523 | Drug Info | Phase 1 | Female sexual dysfunction | [536493] | |
SSR-181507 | Drug Info | Phase 1 | Schizophrenia | [536463] | |
Umespirone | Drug Info | Phase 1 | Anxiety disorder | [544712] | |
CM-2236 | Drug Info | Preclinical | Post-traumatic stress disorder | [548834] | |
PD-158771 | Drug Info | Preclinical | Schizophrenia | [536463] | |
LYSERGIC ACID DIETHYLAMIDE | Drug Info | Withdrawn from market | Addiction | [526769], [539053] | |
Bifeprunox | Drug Info | Discontinued in Phase 3 | Schizophrenia | [536463] | |
BMS-181100 | Drug Info | Discontinued in Phase 3 | Psychotic disorders | [542913], [544706] | |
Flesinoxan | Drug Info | Discontinued in Phase 3 | Anxiety disorder | [538607], [544790] | |
Sunepitron | Drug Info | Discontinued in Phase 3 | Discovery agent | [545699] | |
TIOSPIRONE | Drug Info | Discontinued in Phase 3 | Discovery agent | [538617], [544679] | |
Xaliproden | Drug Info | Discontinued in Phase 3 | Alzheimer disease; Peripheral sensory neuropathies; Lateral sclerosis | [544941] | |
Adatanserin | Drug Info | Discontinued in Phase 2 | Severe mood disorders | [536580] | |
ALNESPIRONE | Drug Info | Discontinued in Phase 2 | Anxiety disorder | [544887] | |
AP-521 | Drug Info | Discontinued in Phase 2 | Anxiety disorder | [545798] | |
DU 125530 | Drug Info | Discontinued in Phase 2 | Mood disorder | [547248] | |
GSK163090 | Drug Info | Discontinued in Phase 2 | Major depressive disorder; Episode; Anxiety | [548510] | |
LESOPITRON DIHYDROCHLORIDE | Drug Info | Discontinued in Phase 2 | Mood disorder | [544898] | |
MAZAPERTINE | Drug Info | Discontinued in Phase 2 | Discovery agent | [545274] | |
PRX-00023 | Drug Info | Discontinued in Phase 2 | Severe mood disorders | [536580] | |
REC-15/3079 | Drug Info | Discontinued in Phase 2 | Urinary incontinence | [542421], [546820] | |
Robalzotan | Drug Info | Discontinued in Phase 2 | Anxiety disorder | [542212], [546103] | |
Sarizotan | Drug Info | Discontinued in Phase 2 | Parkinson's disease | [536923] | |
BINOSPIRONE MESYLATE | Drug Info | Discontinued in Phase 1 | Anxiety disorder | [544704] | |
DU-29894 | Drug Info | Discontinued in Phase 1 | Psychotic disorders | [544888] | |
E2101 | Drug Info | Discontinued in Phase 1 | Cervical dystonia; Spasm | [547174] | |
Ebalzotan | Drug Info | Discontinued in Phase 1 | Anxiety disorder | [546211] | |
Eptapirone | Drug Info | Discontinued in Phase 1 | Anxiety disorder | [546879] | |
GR-127607 | Drug Info | Discontinued in Phase 1 | Migraine | [545504] | |
Nerisopam | Drug Info | Discontinued in Phase 1 | Anxiety disorder | [544884] | |
SLV-313 | Drug Info | Discontinued in Phase 1 | Schizophrenia | [536463] | |
SUN-8399 | Drug Info | Discontinued in Phase 1 | Anxiety disorder | [544893] | |
U-93385 | Drug Info | Discontinued in Phase 1 | Anxiety disorder | [545114] | |
1192U90 | Drug Info | Terminated | Schizophrenia | [536463] | |
A-74283 | Drug Info | Terminated | Hypertension | [545136] | |
A-80426 | Drug Info | Terminated | Discovery agent | [546043] | |
Anpirtoline | Drug Info | Terminated | Pain | [528148] | |
BMY-7378 | Drug Info | Terminated | Discovery agent | [543289], [544847] | |
BTS-79018 | Drug Info | Terminated | Schizophrenia | [536463] | |
CGS-18102A | Drug Info | Terminated | Anxiety disorder | [545030] | |
CP-293019 | Drug Info | Terminated | Discovery agent | [543340], [546533] | |
Du-123015 | Drug Info | Terminated | Anxiety disorder | [550366] | |
Gepirone ER | Drug Info | Terminated | Depression | [536580] | |
HT-90B | Drug Info | Terminated | Anxiety disorder | [545512] | |
Ipsapirone | Drug Info | Terminated | Anxiety disorder | [467532], [544710] | |
LY-293284 | Drug Info | Terminated | Anxiety disorder | [539199], [545514] | |
NAN-190 | Drug Info | Terminated | Discovery agent | [542320], [544809] | |
RWJ-25730 | Drug Info | Terminated | Psychotic disorders | [544892] | |
S-14506 | Drug Info | Terminated | Anxiety disorder | [539527], [544866] | |
SDZ 216-525 | Drug Info | Terminated | Discovery agent | [542751], [544906] | |
SDZ-MAR-327 | Drug Info | Terminated | Schizophrenia | [536463] | |
SLV-307 | Drug Info | Terminated | Parkinson's disease | [551583] | |
WAY 100135 | Drug Info | Terminated | Discovery agent | [542821], [545080] | |
WAY-100635 | Drug Info | Terminated | Eating disorder | [542914], [545310] | |
WB-4101 | Drug Info | Terminated | Discovery agent | [468117], [545656] | |
Sunepitron | Drug Info | Investigative | Unspecified | [528210] | |
Inhibitor | (3-Chloro-phenyl)-piperazin-1-yl-methanone | Drug Info | [533476] | ||
(R)-(-)-10-methyl-11-hydroxyaporphine | Drug Info | [528876] | |||
(R)-11-Amino-2-methoxyaporphine | Drug Info | [529541] | |||
(R)-2,11-Diaminoaporphine | Drug Info | [529541] | |||
1,2,3,4-Tetrahydro-naphthalen-2-ylamine | Drug Info | [533482] | |||
1,6-bis(4-(3-chlorophenyl)piperazin-1-yl)hexane | Drug Info | [530927] | |||
1,6-bis(4-(3-methoxyphenyl)piperazin-1-yl)hexane | Drug Info | [530927] | |||
1,6-bis(4-(pyridin-2-yl)piperazin-1-yl)hexane | Drug Info | [530927] | |||
1,6-bis(4-m-tolylpiperazin-1-yl)hexane | Drug Info | [530927] | |||
1,6-bis(4-phenylpiperazin-1-yl)hexane | Drug Info | [530927] | |||
1-((S)-2-aminopropyl)-1H-indazol-6-ol | Drug Info | [527952] | |||
1-(2,5-Dimethoxy-4-methyl-phenyl)-piperazine | Drug Info | [533476] | |||
1-(2,5-Dimethoxy-phenyl)-piperazine | Drug Info | [533476] | |||
1-(2,5-dimethoxyphenyl)propan-2-amine | Drug Info | [533498] | |||
1-(2-((3-fluorophenoxy)methyl)phenyl)piperazine | Drug Info | [530474] | |||
1-(2-(2-chlorophenoxy)pyridin-3-yl)piperazine | Drug Info | [530596] | |||
1-(2-(2-fluorobenzyloxy)phenyl)piperazine | Drug Info | [530474] | |||
1-(2-(3-fluorophenoxy)phenyl)piperazine | Drug Info | [530474] | |||
1-(2-(4-fluorophenoxy)phenyl)piperazine | Drug Info | [530474] | |||
1-(2-(benzyloxy)phenyl)piperazine | Drug Info | [530474] | |||
1-(2-(phenoxymethyl)phenyl)piperazine | Drug Info | [530474] | |||
1-(2-Butoxy-phenyl)-piperazine | Drug Info | [533134] | |||
1-(2-Chloro-phenyl)-piperazine | Drug Info | [528039] | |||
1-(2-Ethoxy-phenyl)-piperazine | Drug Info | [533134] | |||
1-(2-Fluoro-phenyl)-piperazine | Drug Info | [533134] | |||
1-(2-Isopropoxy-phenyl)-piperazine | Drug Info | [533134] | |||
1-(2-Methoxy-phenyl)-4-propyl-piperazine | Drug Info | [533873] | |||
1-(2-Methoxy-phenyl)-piperazine | Drug Info | [528039] | |||
1-(2-methoxyphenyl)-4-pentylpiperazine | Drug Info | [531189] | |||
1-(2-phenoxyphenyl)piperazine | Drug Info | [530474] | |||
1-(3-(pentafluorosulfanyl)phenyl)propan-2-amine | Drug Info | [529013] | |||
1-(3-Fluoro-phenyl)-piperazine | Drug Info | [533134] | |||
1-(3-Nitro-phenyl)-piperazine | Drug Info | [533134] | |||
1-(3-Trifluoromethyl-phenyl)-piperazine | Drug Info | [533476] | |||
1-(4-Bromo-2,5-dimethoxy-phenyl)-piperazine | Drug Info | [533476] | |||
1-(7-Methoxy-naphthalen-2-yl)-piperazine | Drug Info | [534528] | |||
1-(benzyloxy)-2-(2-phenylethyl)benzene | Drug Info | [528493] | |||
1-(benzyloxy)-2-[2-(3-methoxyphenyl)ethyl]benzene | Drug Info | [528493] | |||
1-Benzyl-4-chroman-2-ylmethyl-piperazine | Drug Info | [527368] | |||
1-Butyl-4-(2-methoxy-phenyl)-piperazine | Drug Info | [533873] | |||
1-Ethyl-4-(2-methoxy-phenyl)-piperazine | Drug Info | [533873] | |||
1-Methyl-1,3-dihydro-indol-2-one | Drug Info | [526055] | |||
1-Naphthalen-1-yl-piperazine | Drug Info | [533482] | |||
1-Naphthalen-2-yl-piperazine | Drug Info | [533482] | |||
1-Propyl-3-(3-trifluoromethyl-phenyl)-pyrrolidine | Drug Info | [551334] | |||
1-[(3-methoxybenzyl)oxy]-2-(2-phenylethyl)benzene | Drug Info | [528493] | |||
2-(2'-methyl-biphenyl-3-yl)-ethylamine | Drug Info | [528780] | |||
2-(2-Amino-propyl)-5-bromo-4-methoxy-phenol | Drug Info | [533498] | |||
2-(2-chlorophenoxy)-3-(piperidin-4-yl)pyridine | Drug Info | [530596] | |||
2-(2-fluorophenoxy)-3-(piperidin-4-yl)pyridine | Drug Info | [530596] | |||
2-(2-Methoxy-phenyl)-1-methyl-ethylamine | Drug Info | [533498] | |||
2-(2-methoxyphenoxy)-3-(piperidin-4-yl)pyridine | Drug Info | [530596] | |||
2-(3-Bromophenylthio)-N,N-dimethylethanamine | Drug Info | [530699] | |||
2-(3-Methoxy-phenyl)-1-methyl-ethylamine | Drug Info | [533498] | |||
2-(4-Benzyl-piperidin-1-ylmethyl)-chroman-4-one | Drug Info | [527368] | |||
2-(4-Bromo-2-methoxy-phenyl)-1-methyl-ethylamine | Drug Info | [533498] | |||
2-(4-Bromo-phenyl)-1-methyl-ethylamine | Drug Info | [533498] | |||
2-(4-Methyl-piperazin-1-yl)-4-phenyl-pyrimidine | Drug Info | [551319] | |||
2-(5-Methoxy-1H-indol-3-yl)-1-methyl-ethylamine | Drug Info | [526713] | |||
2-(Biphenyl-3-ylthio)-N,N-dimethylethanamine | Drug Info | [530699] | |||
2-Dipropylamino-1,2,3,4-tetrahydro-anthracen-9-ol | Drug Info | [551246] | |||
2-phenoxy-3-(piperidin-4-yl)pyridine | Drug Info | [530596] | |||
2-Piperazin-1-yl-benzonitrile | Drug Info | [533134] | |||
2-Piperazin-1-yl-phenol | Drug Info | [533476] | |||
2-{[2-(2-phenylethyl)phenoxy]methyl}pyridine | Drug Info | [528493] | |||
3-(1,2,3,6-Tetrahydro-pyridin-4-yl)-1H-indole | Drug Info | [532389] | |||
3-(1-Propyl-pyrrolidin-3-yl)-phenol | Drug Info | [551334] | |||
3-(2-Amino-propyl)-1H-indol-5-ol | Drug Info | [526713] | |||
3-(2-Benzylamino-ethoxy)-phenol | Drug Info | [534787] | |||
3-(3-Methanesulfonyl-phenyl)-1-propyl-pyrrolidine | Drug Info | [551334] | |||
3-(4-Benzyl-piperidin-1-ylmethyl)-chroman-4-one | Drug Info | [527368] | |||
3-(4-Benzyl-piperidin-1-ylmethyl)-chromen-4-one | Drug Info | [527368] | |||
3-(piperidin-4-yl)-2-(o-tolyloxy)pyridine | Drug Info | [530596] | |||
3-Amino-1-(2-amino-5-methoxy-phenyl)-propan-1-one | Drug Info | [533476] | |||
3-Butyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-6-ol | Drug Info | [526822] | |||
3-Ethyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-6-ol | Drug Info | [526822] | |||
3-Naphthalen-1-yl-1-propyl-pyrrolidine | Drug Info | [551334] | |||
3-Naphthalen-1-yl-pyrrolidine | Drug Info | [551334] | |||
3-Phenyl-1-propyl-pyrrolidine | Drug Info | [551334] | |||
3-{[2-(2-phenylethyl)phenoxy]methyl}pyridine | Drug Info | [528493] | |||
4-(1H-indol-4-yloxy)-1-(isopropylamino)butan-2-ol | Drug Info | [529018] | |||
4-(2-(2-fluoro-5-methylphenoxy)phenyl)piperidine | Drug Info | [530474] | |||
4-(2-(2-fluorobenzyloxy)phenyl)piperidine | Drug Info | [530474] | |||
4-(2-(3-chlorophenoxy)phenyl)piperidine | Drug Info | [530474] | |||
4-(2-(3-fluorophenoxy)phenyl)piperidine | Drug Info | [530474] | |||
4-(2-(4-fluorobenzyloxy)phenyl)piperidine | Drug Info | [530474] | |||
4-(2-(4-fluorophenoxy)phenyl)piperidine | Drug Info | [530474] | |||
4-(2-(benzyloxy)-3-fluorophenyl)piperidine | Drug Info | [530474] | |||
4-(2-(benzyloxy)-6-fluorophenyl)piperidine | Drug Info | [530474] | |||
4-(2-(benzyloxy)phenyl)piperidine | Drug Info | [530474] | |||
4-(2-fluoro-6-(2-fluorophenoxy)phenyl)piperidine | Drug Info | [530596] | |||
4-(2-fluoro-6-(3-fluorophenoxy)phenyl)piperidine | Drug Info | [530474] | |||
4-(2-fluoro-6-(4-fluorophenoxy)phenyl)piperidine | Drug Info | [530474] | |||
4-(2-fluoro-6-phenoxyphenyl)piperidine | Drug Info | [530474] | |||
4-(2-phenoxyphenyl)piperidine | Drug Info | [530474] | |||
4-(3-fluoro-2-phenoxyphenyl)piperidine | Drug Info | [530474] | |||
4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one | Drug Info | [531079] | |||
4-Benzyl-1-chroman-2-ylmethyl-piperidine | Drug Info | [527368] | |||
4-Benzyl-1-chroman-3-ylmethyl-piperidine | Drug Info | [527368] | |||
5,6-dichloro-3,4-dihydroquinazolin-2-amine | Drug Info | [529148] | |||
5-chloro-3,4-dihydroquinazolin-2-amine | Drug Info | [529148] | |||
5-chloro-4-ethyl-3,4-dihydroquinazolin-2-amine | Drug Info | [529148] | |||
5-chloro-4-methyl-3,4-dihydroquinazolin-2-amine | Drug Info | [529148] | |||
8-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-ylamine | Drug Info | [551246] | |||
8-Methoxy-2-(4-methyl-piperazin-1-yl)-quinoline | Drug Info | [533482] | |||
8-Methoxy-2-piperazin-1-yl-quinoline | Drug Info | [533482] | |||
8-methoxy-4-methyl-3,4-dihydroquinazolin-2-amine | Drug Info | [529148] | |||
8-Methoxy-quinolin-2-ylamine | Drug Info | [533482] | |||
9-Methoxy-1,2,3,4-tetrahydro-anthracen-2-ylamine | Drug Info | [551246] | |||
A-80426 | Drug Info | [527799] | |||
A-987306 | Drug Info | [529789] | |||
AGROCLAVINE | Drug Info | [532683] | |||
BMY-7378 | Drug Info | [534142] | |||
Brolamfetamine | Drug Info | [533498] | |||
CHLOROPHENYLPIPERAZINE | Drug Info | [533134] | |||
CP-293019 | Drug Info | [534783] | |||
ESCHOLTZINE | Drug Info | [528095] | |||
Etisulergine | Drug Info | [533501] | |||
JNJ-10392980 | Drug Info | [529569] | |||
LYSERGIC ACID DIETHYLAMIDE | Drug Info | [533701] | |||
MAZAPERTINE | Drug Info | [533800] | |||
MCL-516 | Drug Info | [529541] | |||
N-(3-(1H-indol-4-yloxy)propyl)cyclohexanamine | Drug Info | [529018] | |||
N-(3-(1H-indol-4-yloxy)propyl)cyclopentanamine | Drug Info | [529018] | |||
N-Benzyl-4-(2-diphenyl)-1-piperazinehexanamide | Drug Info | [529703] | |||
N-methyllaurotetanine | Drug Info | [528095] | |||
N-[4-(4-Phenyl-piperazin-1-yl)-butyl]-benzamide | Drug Info | [533428] | |||
PB-28 | Drug Info | [534094] | |||
PG-01037 | Drug Info | [528974] | |||
PHENYLPIPERAZINE | Drug Info | [533482] | |||
QUIPAZINE | Drug Info | [530451] | |||
SB-271046 | Drug Info | [529191] | |||
SB-656104 | Drug Info | [527395] | |||
SEROTONIN | Drug Info | [530451] | |||
SNAP-8719 | Drug Info | [527512] | |||
SPIPERONE | Drug Info | [533936] | |||
Sunepitron | Drug Info | [528210] | |||
TERTATOLOL | Drug Info | [551246] | |||
TIOSPIRONE | Drug Info | [528304] | |||
UH-232 | Drug Info | [551330] | |||
UH-301 | Drug Info | [534363] | |||
WAY-466 | Drug Info | [527381] | |||
WB-4101 | Drug Info | [533936] | |||
Antagonist | (R)-flurocarazolol | Drug Info | [526124] | ||
(S)-flurocarazolol | Drug Info | [526124] | |||
(S)-UH-301 | Drug Info | [538050] | |||
(S)-WAY 100135 | Drug Info | [538050] | |||
9-OH-risperidone | Drug Info | [534281] | |||
AV-965 | Drug Info | [548414] | |||
BINOSPIRONE MESYLATE | Drug Info | [526194], [551871] | |||
cyamemazine | Drug Info | [526510] | |||
DSP-1053 | Drug Info | [533288] | |||
DU 125530 | Drug Info | [535456] | |||
GR 125,743 | Drug Info | [534412] | |||
GSK-958108 | Drug Info | [551853] | |||
GSK163090 | Drug Info | [550963] | |||
LECOZOTAN HYDROCHLORIDE | Drug Info | [528845], [551871] | |||
LY433221 | Drug Info | [536286] | |||
MIN-117 | Drug Info | [550002] | |||
MPDT | Drug Info | [525722] | |||
NAN-190 | Drug Info | [538050] | |||
ORG-13011 | Drug Info | [525547], [551871] | |||
P-MPPI | Drug Info | [538050], [538142] | |||
p-[18F]MPPF | Drug Info | [527909] | |||
PD-158771 | Drug Info | [536463] | |||
REC-15/3079 | Drug Info | [526201] | |||
repinotan | Drug Info | [534575] | |||
Robalzotan | Drug Info | [535041] | |||
RP5063 | Drug Info | [549962], [551645] | |||
S-15535 | Drug Info | [525641], [551871] | |||
SB 272183 | Drug Info | [526100] | |||
SB 649915 | Drug Info | [527551] | |||
SB 714786 | Drug Info | [527551] | |||
SDZ 216-525 | Drug Info | [538050] | |||
SLV-307 | Drug Info | [527204] | |||
TGWOOAA | Drug Info | [550645] | |||
Treximet | Drug Info | [550963] | |||
Umespirone | Drug Info | [528329] | |||
WAY 100135 | Drug Info | [538050] | |||
WAY-100635 | Drug Info | [535073], [535298], [535456] | |||
Xaliproden | Drug Info | [549823] | |||
[11C]WAY100635 | Drug Info | [527424] | |||
[3H]p-MPPF | Drug Info | [527360] | |||
[3H]robalzotan | Drug Info | [534771] | |||
[3H]WAY100635 | Drug Info | [534329] | |||
Agonist | 1-naphthylpiperazine | Drug Info | [534528] | ||
1192U90 | Drug Info | [536463] | |||
5-CT | Drug Info | [534412] | |||
7-methoxy-1-naphthylpiperazine | Drug Info | [534528] | |||
A-74283 | Drug Info | [534558] | |||
Adatanserin | Drug Info | [534942], [536580] | |||
ALNESPIRONE | Drug Info | [534835], [551871] | |||
AP-521 | Drug Info | [533147], [551871] | |||
BRL-15572 | Drug Info | [534475] | |||
Buspirone | Drug Info | [536213] | |||
CM-2236 | Drug Info | [550867] | |||
CM-2395 | Drug Info | [548980] | |||
CP 93129 | Drug Info | [534412] | |||
Dual norepinephrine reuptake inhibitors/5-HT1A partial agonists | Drug Info | [543357] | |||
Ebalzotan | Drug Info | [526199] | |||
Eltoprazine | Drug Info | [551057] | |||
EMDT | Drug Info | [525722] | |||
Eptapirone | Drug Info | [527844] | |||
FG-5893 | Drug Info | [534714] | |||
Flesinoxan | Drug Info | [525612] | |||
Gepirone ER | Drug Info | [536580] | |||
GR-127607 | Drug Info | [545505] | |||
Ipsapirone | Drug Info | [536988] | |||
L-772,405 | Drug Info | [525646] | |||
LESOPITRON DIHYDROCHLORIDE | Drug Info | [533618] | |||
LP-12 | Drug Info | [528956] | |||
LP-211 | Drug Info | [529703] | |||
LP-44 | Drug Info | [528956] | |||
LY 165,163 | Drug Info | [534714] | |||
LY-293284 | Drug Info | [533615] | |||
MN-305 | Drug Info | [536580] | |||
nafadotride | Drug Info | [534714] | |||
Nerisopam | Drug Info | [534238] | |||
Neu-P11 | Drug Info | [551415] | |||
piribedil | Drug Info | [526443] | |||
S-14671 | Drug Info | [534606] | |||
SB 216641 | Drug Info | [534475] | |||
spiroxatrine | Drug Info | [534714] | |||
SUN N4057 | Drug Info | [535277] | |||
SUN-8399 | Drug Info | [533869] | |||
U-93385 | Drug Info | [533820], [551871] | |||
U92016A | Drug Info | [533822] | |||
Urapidil | Drug Info | [538139] | |||
Zalospirone | Drug Info | [533189] | |||
[3H]8-OH-DPAT | Drug Info | [525927] | |||
[3H]NLX-112 | Drug Info | [531129] | |||
[3H]S-15535 | Drug Info | [534606] | |||
Modulator | Anpirtoline | Drug Info | [528148] | ||
Bifeprunox | Drug Info | ||||
BMS-181100 | Drug Info | ||||
CGS-18102A | Drug Info | [526784] | |||
CGS-19480A | Drug Info | [550159], [551871] | |||
Du-123015 | Drug Info | [550367] | |||
DU-29894 | Drug Info | [533724] | |||
E2101 | Drug Info | [535482] | |||
EMD 56551 | Drug Info | ||||
Ensaculin hydrochloride | Drug Info | [526403] | |||
Flibanserin | Drug Info | [532651] | |||
HT-90B | Drug Info | [534198] | |||
Mazapertine succinate | Drug Info | ||||
NLX-101 | Drug Info | ||||
NPT-500 | Drug Info | [543357] | |||
OPC-14523 | Drug Info | [552279] | |||
OPC-34712 | Drug Info | ||||
PRX-00023 | Drug Info | ||||
RWJ-25730 | Drug Info | ||||
S-14506 | Drug Info | ||||
S-16924 | Drug Info | [525424], [534704] | |||
Sarizotan | Drug Info | ||||
SDZ-MAR-327 | Drug Info | ||||
SEL-73 | Drug Info | [543357] | |||
SKL-PSY | Drug Info | [543357] | |||
SLV-313 | Drug Info | ||||
SR-59026 | Drug Info | ||||
SSR-181507 | Drug Info | ||||
TGBA01AD | Drug Info | ||||
TGFK08AA-ER | Drug Info | [525395] | |||
TGFK09SD-ER | Drug Info | [549115] | |||
Trazodone | Drug Info | [556264] | |||
Vilazodone | Drug Info | [531783] | |||
Binder | BTS-79018 | Drug Info | [536463] | ||
Modulator (allosteric modulator) | RS-30199 | Drug Info | [534687] | ||
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM) | |||||
TEP | EXP Info | ||||
Pathways | |||||
KEGG Pathway | cAMP signaling pathway | ||||
Neuroactive ligand-receptor interaction | |||||
Serotonergic synapse | |||||
PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
5HT1 type receptor mediated signaling pathway | |||||
Reactome | Serotonin receptors | ||||
G alpha (i) signalling events | |||||
WikiPathways | Serotonin HTR1 Group and FOS Pathway | ||||
SIDS Susceptibility Pathways | |||||
Monoamine GPCRs | |||||
GPCRs, Class A Rhodopsin-like | |||||
GPCR ligand binding | |||||
GPCR downstream signaling | |||||
References | |||||
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Ref 534704 | S 16924 ((R)-2-[1-[2-(2,3-dihydro-benzo[1,4] dioxin-5-Yloxy)-ethyl]-pyrrolidin-3yl]-1-(4-fluoro-phenyl)-ethanone), a novel, potential antipsychotic with marked serotonin (5-HT)1A agonist properties: I. Receptorial and neurochemical profile in comparison with clozapine and haloperidol. J Pharmacol Exp Ther. 1998 Sep;286(3):1341-55. | ||||
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Ref 538617 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 101). | ||||
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Ref 539527 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 24). | ||||
Ref 539677 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 26). | ||||
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Ref 542212 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 72). | ||||
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Ref 544679 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000562) | ||||
Ref 544704 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000677) | ||||
Ref 544706 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000679) | ||||
Ref 544710 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000695) | ||||
Ref 544712 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000698) | ||||
Ref 544790 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001126) | ||||
Ref 544809 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001193) | ||||
Ref 544847 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001317) | ||||
Ref 544866 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001368) | ||||
Ref 544884 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001415) | ||||
Ref 544887 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001421) | ||||
Ref 544888 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001422) | ||||
Ref 544892 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001430) | ||||
Ref 544893 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001433) | ||||
Ref 544898 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001441) | ||||
Ref 544906 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001469) | ||||
Ref 544941 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001601) | ||||
Ref 545030 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001927) | ||||
Ref 545080 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002060) | ||||
Ref 545114 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002172) | ||||
Ref 545119 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002186) | ||||
Ref 545136 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002258) | ||||
Ref 545274 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002662) | ||||
Ref 545310 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002783) | ||||
Ref 545504 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003531) | ||||
Ref 545512 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003558) | ||||
Ref 545514 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003567) | ||||
Ref 545656 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004048) | ||||
Ref 545699 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004255) | ||||
Ref 545798 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004776) | ||||
Ref 546043 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006017) | ||||
Ref 546103 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006370) | ||||
Ref 546211 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006909) | ||||
Ref 546533 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008823) | ||||
Ref 546820 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010455) | ||||
Ref 546879 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010848) | ||||
Ref 547174 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800013610) | ||||
Ref 547248 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800014469) | ||||
Ref 548413 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025412) | ||||
Ref 548510 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800026154) | ||||
Ref 548834 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800029346) | ||||
Ref 549451 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800037483) | ||||
Ref 550366 | Neither in vivo MRI nor behavioural assessment indicate therapeutic efficacy for a novel 5HT1A agonist in rat models of ischaemic stroke. BMC Neuroscience 2009, 10:82. | ||||
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