| Drug General Information |
| Drug ID |
D0CG2Y
|
| Former ID |
DNC010331
|
| Drug Name |
2-phenoxy-3-(piperidin-4-yl)pyridine
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C16H18N2O
|
| Canonical SMILES |
C1CNCCC1C2=C(N=CC=C2)OC3=CC=CC=C3
|
| InChI |
1S/C16H18N2O/c1-2-5-14(6-3-1)19-16-15(7-4-10-18-16)13-8-11-17-12-9-13/h1-7,10,13,17H,8-9,11-12H2
|
| InChIKey |
LKVOLTSPLLAMPJ-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Sodium-dependent serotonin transporter |
Target Info |
Inhibitor |
[1]
|
|---|
| 5-hydroxytryptamine 1A receptor |
Target Info |
Inhibitor |
[1]
|
| Sodium-dependent dopamine transporter |
Target Info |
Inhibitor |
[1]
|
| Sodium-dependent noradrenaline transporter |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
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Serotonergic synapsehsa04024:cAMP signaling pathway
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Neuroactive ligand-receptor interaction
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Serotonergic synapsehsa04728:Dopaminergic synapse
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Parkinson's disease
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Cocaine addiction
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Amphetamine addiction
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Alcoholism
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NetPath Pathway
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TCR Signaling Pathway
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PANTHER Pathway
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5HT1 type receptor mediated signaling pathway
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5HT2 type receptor mediated signaling pathway
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5HT3 type receptor mediated signaling pathway
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5HT4 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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5HT1 type receptor mediated signaling pathwayP00001:Adrenaline and noradrenaline biosynthesis
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Parkinson disease
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Dopamine receptor mediated signaling pathwayP00001:Adrenaline and noradrenaline biosynthesis
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Pathway Interaction Database
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Alpha-synuclein signaling
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Reactome
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Serotonin receptors
|
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G alpha (i) signalling eventsR-HSA-442660:Na+/Cl- dependent neurotransmitter transportersR-HSA-442660:Na+/Cl- dependent neurotransmitter transporters
|
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WikiPathways
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Monoamine Transport
|
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SIDS Susceptibility Pathways
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NRF2 pathway
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Synaptic Vesicle Pathway
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Serotonin Transporter ActivityWP722:Serotonin HTR1 Group and FOS Pathway
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Monoamine GPCRs
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GPCRs, Class A Rhodopsin-like
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GPCR ligand binding
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GPCR downstream signalingWP727:Monoamine Transport
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Dopaminergic Neurogenesis
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Parkinsons Disease Pathway
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Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
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Neurotransmitter Clearance In The Synaptic CleftWP727:Monoamine Transport
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| References |
| REF 1 | Bioorg Med Chem Lett. 2010 Feb 1;20(3):1114-7. Epub 2009 Dec 6.Design, synthesis, and pharmacological evaluation of phenoxy pyridyl derivatives as dual norepinephrine reuptake inhibitors and 5-HT1A partial agonists. |
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