Drug Information

Drug General Information
Drug ID
D0ZU5W
Former ID
DNC010045
Drug Name
1-(2-(benzyloxy)phenyl)piperazine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530474]
Structure
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2D MOL

3D MOL
Formula
C17H20N2O
Canonical SMILES
C1CN(CCN1)C2=CC=CC=C2OCC3=CC=CC=C3
InChI
1S/C17H20N2O/c1-2-6-15(7-3-1)14-20-17-9-5-4-8-16(17)19-12-10-18-11-13-19/h1-9,18H,10-14H2
InChIKey
PPQUPQGZDGZYJI-UHFFFAOYSA-N
PubChem Compound ID
22615724
Target and Pathway
Target(s) Sodium-dependent noradrenaline transporter Target Info Inhibitor [530474]
Sodium-dependent serotonin transporter Target Info Inhibitor [530474]
5-hydroxytryptamine 1A receptor Target Info Inhibitor [530474]
KEGG Pathway Serotonergic synapsehsa04024:cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Adrenaline and noradrenaline biosynthesisP04373:5HT1 type receptor mediated signaling pathway
5HT2 type receptor mediated signaling pathway
5HT3 type receptor mediated signaling pathway
5HT4 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Na+/Cl- dependent neurotransmitter transportersR-HSA-390666:Serotonin receptors
G alpha (i) signalling events
WikiPathways Monoamine Transport
NRF2 pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsWP727:Monoamine Transport
SIDS Susceptibility Pathways
Synaptic Vesicle Pathway
Serotonin Transporter ActivityWP722:Serotonin HTR1 Group and FOS Pathway
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 530474Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. Epub 2009 Oct 12.Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1A partial agonists.
Ref 530474Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. Epub 2009 Oct 12.Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1A partial agonists.

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