| Drug General Information |
| Drug ID |
D0M2ZE
|
| Former ID |
DNC003670
|
| Drug Name |
UH-232
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C18H27NO
|
| InChI |
InChI=1S/C18H27NO/c1-5-12-19(13-6-2)17-11-10-16-15(14(17)3)8-7-9-18(16)20-4/h7-11,14,17H,5-6,12-13H2,1-4H3/t14-,17+/m0/s1
|
| InChIKey |
YNNTVNSZMGTKJL-WMLDXEAASA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
|
| Target and Pathway |
| Target(s) |
D(4) dopamine receptor |
Target Info |
Inhibitor |
[2]
|
|---|
| D(2) dopamine receptor |
Target Info |
Inhibitor |
[2]
|
| 5-hydroxytryptamine 1A receptor |
Target Info |
Inhibitor |
[2]
|
| D(3) dopamine receptor |
Target Info |
Inhibitor |
[2]
|
|
KEGG Pathway
|
Neuroactive ligand-receptor interaction
|
|
Dopaminergic synapsehsa04015:Rap1 signaling pathway
|
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cAMP signaling pathway
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Gap junction
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Dopaminergic synapse
|
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Parkinson's disease
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Cocaine addiction
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Alcoholismhsa04024:cAMP signaling pathway
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Serotonergic synapsehsa04080:Neuroactive ligand-receptor interaction
|
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PANTHER Pathway
|
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
|
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Dopamine receptor mediated signaling pathway
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Nicotine pharmacodynamics pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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5HT1 type receptor mediated signaling pathway
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Reactome
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Dopamine receptors
|
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G alpha (i) signalling eventsR-HSA-390651:Dopamine receptors
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G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
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G alpha (i) signalling events
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WikiPathways
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Hypothetical Network for Drug Addiction
|
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Monoamine GPCRs
|
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GPCRs, Class A Rhodopsin-like
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Genes and (Common) Pathways Underlying Drug Addiction
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GPCR ligand binding
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GPCR downstream signaling
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Nicotine Activity on Dopaminergic Neurons
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GPCRs, OtherWP666:Hypothetical Network for Drug Addiction
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Nicotine Activity on Dopaminergic NeuronsWP722:Serotonin HTR1 Group and FOS Pathway
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SIDS Susceptibility Pathways
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GPCR downstream signalingWP58:Monoamine GPCRs
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GPCRs, Other
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| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 957). |
|---|
| REF 2 | (Dipropylamino)-tetrahydronaphthofurans: centrally acting serotonin agonists and dopamine agonists-antagonists, Bioorg. Med. Chem. Lett. 7(21):2759-2764 (1997). |
|---|
