Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D02FNU
|
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| Former ID |
DNC000807
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| Drug Name |
Ipsapirone
|
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| Drug Type |
Small molecular drug
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| Indication | Anxiety disorder [ICD9: 300, 311; ICD10:F32, F40-F42] | Terminated | [1], [2] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C19H23N5O3S
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| InChI |
InChI=1S/C19H23N5O3S/c25-18-16-6-1-2-7-17(16)28(26,27)24(18)11-4-3-10-22-12-14-23(15-13-22)19-20-8-5-9-21-19/h1-2,5-9H,3-4,10-15H2
|
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| InChIKey |
TZJUVVIWVWFLCD-UHFFFAOYSA-N
|
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| CAS Number |
CAS 92589-98-5
|
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| PubChem Compound ID | |||||
| PubChem Substance ID |
7603533, 8184984, 11114236, 12013978, 14903693, 43114717, 47285840, 47731233, 49883567, 50326777, 57313863, 85209405, 85788167, 91746214, 103166960, 103918673, 104311449, 104827256, 117598635, 119525529, 129335952, 134338757, 134340130, 135015567, 135650411, 135698194, 137231966, 142141651, 144204513, 162023316, 162222165, 163135249, 170466380, 175611931, 179151468, 184536638, 198972236, 202544113, 224910665, 226458694, 252156151, 252330661, 252450956, 252562161
|
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| Target and Pathway | |||||
| Target(s) | 5-hydroxytryptamine 1A receptor | Target Info | Agonist | [3] | |
| KEGG Pathway | cAMP signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Serotonergic synapse | |||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| 5HT1 type receptor mediated signaling pathway | |||||
| Reactome | Serotonin receptors | ||||
| G alpha (i) signalling events | |||||
| WikiPathways | Serotonin HTR1 Group and FOS Pathway | ||||
| SIDS Susceptibility Pathways | |||||
| Monoamine GPCRs | |||||
| GPCRs, Class A Rhodopsin-like | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 42). | ||||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000695) | ||||
| REF 3 | Chronic voluntary ethanol intake hypersensitizes 5-HT(1A) autoreceptors in C57BL/6J mice. J Neurochem. 2008 Dec;107(6):1660-70. | ||||
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