| Drug General Information |
| Drug ID |
D0D2PL
|
| Former ID |
DNC005103
|
| Drug Name |
8-Methoxy-quinolin-2-ylamine
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C10H10N2O
|
| Canonical SMILES |
COC1=CC=CC2=C1N=C(C=C2)N
|
| InChI |
1S/C10H10N2O/c1-13-8-4-2-3-7-5-6-9(11)12-10(7)8/h2-6H,1H3,(H2,11,12)
|
| InChIKey |
PMXFKGCLUAFLMH-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
5-hydroxytryptamine 1D receptor |
Target Info |
Inhibitor |
[1]
|
|---|
| 5-hydroxytryptamine 1A receptor |
Target Info |
Inhibitor |
[1]
|
| Melanin-concentrating hormone receptor 1 |
Target Info |
Inhibitor |
[2]
|
|
KEGG Pathway
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cAMP signaling pathway
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Neuroactive ligand-receptor interaction
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Serotonergic synapsehsa04024:cAMP signaling pathway
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Serotonergic synapsehsa04080:Neuroactive ligand-receptor interaction
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PANTHER Pathway
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Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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5HT1 type receptor mediated signaling pathway
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Reactome
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Serotonin receptors
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G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
|
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G alpha (i) signalling eventsR-HSA-375276:Peptide ligand-binding receptors
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G alpha (q) signalling events
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G alpha (i) signalling events
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WikiPathways
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Serotonin HTR1 Group and FOS Pathway
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Monoamine GPCRs
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GPCRs, Class A Rhodopsin-like
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GPCR ligand binding
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GPCR downstream signalingWP722:Serotonin HTR1 Group and FOS Pathway
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SIDS Susceptibility Pathways
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GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
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Gastrin-CREB signalling pathway via PKC and MAPK
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GPCR downstream signaling
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| References |
| REF 1 | J Med Chem. 1986 Nov;29(11):2375-80.5-HT1 and 5-HT2 binding characteristics of some quipazine analogues. |
|---|
| REF 2 | Bioorg Med Chem Lett. 2004 Oct 4;14(19):4873-7.Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 1. |
|---|
