| Drug General Information |
| Drug ID |
D0D9YW
|
| Former ID |
DIB020901
|
| Drug Name |
SB 216641
|
| Synonyms |
SB-216,641; SB-216641
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
|
| Formula |
C28H30N4O4
|
| InChI |
InChI=1S/C28H30N4O4/c1-18-16-22(27-29-19(2)36-31-27)10-12-24(18)20-6-8-21(9-7-20)28(33)30-23-11-13-25(34-5)26(17-23)35-15-14-32(3)4/h6-13,16-17H,14-15H2,1-5H3,(H,30,33)
|
| InChIKey |
JRNUKVFYILMMLX-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
4345731, 7979280, 9258802, 11113989, 14908214, 24724622, 26752130, 29215037, 34695502, 47583700, 47731203, 48029617, 48404444, 57356159, 79302524, 81065497, 85209994, 85788309, 103187949, 111868037, 128317321, 135338242, 135650988, 136351266, 162223688, 179236164, 184527989, 196408595, 225038697, 228477848, 252216261, 252433366
|
| Target and Pathway |
| Target(s) |
5-hydroxytryptamine 1D receptor |
Target Info |
Agonist |
[2]
|
|---|
| 5-hydroxytryptamine 1A receptor |
Target Info |
Agonist |
[2]
|
| 5-hydroxytryptamine 2A receptor |
Target Info |
Agonist |
[2]
|
| 5-hydroxytryptamine 2B receptor |
Target Info |
Agonist |
[2]
|
| 5-hydroxytryptamine 1B receptor |
Target Info |
Agonist |
[2]
|
| 5-hydroxytryptamine 2C receptor |
Target Info |
Agonist |
[2]
|
|
KEGG Pathway
|
cAMP signaling pathway
|
|
Neuroactive ligand-receptor interaction
|
|
Serotonergic synapsehsa04024:cAMP signaling pathway
|
|
Serotonergic synapsehsa04020:Calcium signaling pathway
|
|
Gap junction
|
|
Serotonergic synapse
|
|
Inflammatory mediator regulation of TRP channelshsa04020:Calcium signaling pathway
|
|
Inflammatory mediator regulation of TRP channelshsa04024:cAMP signaling pathway
|
|
Inflammatory mediator regulation of TRP channels
|
|
PANTHER Pathway
|
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
|
5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
|
5HT1 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
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5HT1 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathway
|
|
Reactome
|
Serotonin receptors
|
|
G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
|
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G alpha (q) signalling eventsR-HSA-390666:Serotonin receptors
|
|
G alpha (q) signalling events
|
|
WikiPathways
|
Serotonin HTR1 Group and FOS Pathway
|
|
Monoamine GPCRs
|
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GPCRs, Class A Rhodopsin-like
|
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GPCR ligand binding
|
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GPCR downstream signalingWP722:Serotonin HTR1 Group and FOS Pathway
|
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SIDS Susceptibility Pathways
|
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GPCR downstream signalingWP733:Serotonin Receptor 2 and STAT3 Signaling
|
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Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
|
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Gastrin-CREB signalling pathway via PKC and MAPK
|
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GPCR downstream signaling
|
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GPCRs, OtherWP732:Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
|
|
GPCR downstream signalingWP732:Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
|
| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 28). |
|---|
| REF 2 | SB-216641 and BRL-15572--compounds to pharmacologically discriminate h5-HT1B and h5-HT1D receptors. Naunyn Schmiedebergs Arch Pharmacol. 1997 Sep;356(3):312-20. |
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