| Drug General Information |
| Drug ID |
D03PIP
|
| Former ID |
DNC011040
|
| Drug Name |
1,6-bis(4-(3-methoxyphenyl)piperazin-1-yl)hexane
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C28H42N4O2
|
| Canonical SMILES |
COC1=CC=CC(=C1)N2CCN(CC2)CCCCCCN3CCN(CC3)C4=CC(=CC=C4)O<br />C
|
| InChI |
1S/C28H42N4O2/c1-33-27-11-7-9-25(23-27)31-19-15-29(16-20-31)13-5-3-4-6-14-30-17-21-32(22-18-30)26-10-8-12-28(24-26)34-2/h7-12,23-24H,3-6,13-22H2,1-2H3
|
| InChIKey |
IMWNCWRNMUKPGO-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Potassium voltage-gated channel subfamily H member 2 |
Target Info |
Inhibitor |
[1]
|
|---|
| 5-hydroxytryptamine 2A receptor |
Target Info |
Inhibitor |
[1]
|
| 5-hydroxytryptamine 1A receptor |
Target Info |
Inhibitor |
[1]
|
| D(2) dopamine receptor |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
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Calcium signaling pathway
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Neuroactive ligand-receptor interaction
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|
Gap junction
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Serotonergic synapse
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Inflammatory mediator regulation of TRP channelshsa04024:cAMP signaling pathway
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Serotonergic synapsehsa04015:Rap1 signaling pathway
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cAMP signaling pathway
|
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Dopaminergic synapse
|
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Parkinson's disease
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Cocaine addiction
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Alcoholism
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PANTHER Pathway
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5HT2 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
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Dopamine receptor mediated signaling pathway
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Nicotine pharmacodynamics pathway
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PathWhiz Pathway
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Muscle/Heart Contraction
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Reactome
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Voltage gated Potassium channelsR-HSA-390666:Serotonin receptors
|
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G alpha (q) signalling eventsR-HSA-390666:Serotonin receptors
|
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G alpha (i) signalling eventsR-HSA-390651:Dopamine receptors
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G alpha (i) signalling events
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WikiPathways
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SIDS Susceptibility Pathways
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Hematopoietic Stem Cell Differentiation
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Potassium ChannelsWP733:Serotonin Receptor 2 and STAT3 Signaling
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Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
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Monoamine GPCRs
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GPCRs, Class A Rhodopsin-like
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Gastrin-CREB signalling pathway via PKC and MAPK
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GPCR ligand binding
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GPCR downstream signaling
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GPCRs, OtherWP722:Serotonin HTR1 Group and FOS Pathway
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GPCR downstream signalingWP666:Hypothetical Network for Drug Addiction
|
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Genes and (Common) Pathways Underlying Drug Addiction
|
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Nicotine Activity on Dopaminergic Neurons
|
| References |
| REF 1 | J Med Chem. 2010 Jun 24;53(12):4803-7.Discovery of bishomo(hetero)arylpiperazines as novel multifunctional ligands targeting dopamine D(3) and serotonin 5-HT(1A) and 5-HT(2A) receptors. |
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