| Drug General Information |
| Drug ID |
D0TH8D
|
| Former ID |
DNC012242
|
| Drug Name |
8-Methoxy-2-piperazin-1-yl-quinoline
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C14H17N3O
|
| Canonical SMILES |
COC1=CC=CC2=C1N=C(C=C2)N3CCNCC3
|
| InChI |
1S/C14H17N3O/c1-18-12-4-2-3-11-5-6-13(16-14(11)12)17-9-7-15-8-10-17/h2-6,15H,7-10H2,1H3
|
| InChIKey |
CUULVNAZRYFNIT-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
5-hydroxytryptamine 1D receptor |
Target Info |
Inhibitor |
[1]
|
|---|
| 5-hydroxytryptamine 1A receptor |
Target Info |
Inhibitor |
[1]
|
| 5-hydroxytryptamine 2A receptor |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
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cAMP signaling pathway
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|
Neuroactive ligand-receptor interaction
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|
Serotonergic synapsehsa04024:cAMP signaling pathway
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Serotonergic synapsehsa04020:Calcium signaling pathway
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Gap junction
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Serotonergic synapse
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Inflammatory mediator regulation of TRP channels
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PANTHER Pathway
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Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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5HT1 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathway
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Reactome
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Serotonin receptors
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G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
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G alpha (q) signalling events
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WikiPathways
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Serotonin HTR1 Group and FOS Pathway
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Monoamine GPCRs
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GPCRs, Class A Rhodopsin-like
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GPCR ligand binding
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GPCR downstream signalingWP722:Serotonin HTR1 Group and FOS Pathway
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SIDS Susceptibility Pathways
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GPCR downstream signalingWP733:Serotonin Receptor 2 and STAT3 Signaling
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Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
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Gastrin-CREB signalling pathway via PKC and MAPK
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GPCR downstream signaling
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|
GPCRs, Other
|
| References |
| REF 1 | J Med Chem. 1986 Nov;29(11):2375-80.5-HT1 and 5-HT2 binding characteristics of some quipazine analogues. |
|---|
