| Drug General Information |
| Drug ID |
D00ZEG
|
| Former ID |
DIB010017
|
| Drug Name |
Umespirone
|
| Synonyms |
KC-7218; KC-9172
|
| Drug Type |
Small molecular drug
|
| Indication |
Anxiety disorder [ICD9: 300, 311; ICD10:F32, F40-F42]
|
Phase 1 |
[1]
|
|---|
| Company |
Solvay SA
|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C28H40N4O5
|
| Canonical SMILES |
C12C(=O)N(C(=O)C(C(=O)N(C1=O)CCCCN1CCN(c3c(OC)cccc3)CC1<br />)C2(C)C)CCCC
|
| CAS Number |
CAS 107736-98-1
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
D(2) dopamine receptor |
Target Info |
Antagonist |
[2]
|
|---|
| 5-hydroxytryptamine 1A receptor |
Target Info |
Antagonist |
[2]
|
|
KEGG Pathway
|
Rap1 signaling pathway
|
|
cAMP signaling pathway
|
|
Neuroactive ligand-receptor interaction
|
|
Gap junction
|
|
Dopaminergic synapse
|
|
Parkinson's disease
|
|
Cocaine addiction
|
|
Alcoholismhsa04024:cAMP signaling pathway
|
|
Serotonergic synapse
|
|
PANTHER Pathway
|
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
|
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
|
|
Dopamine receptor mediated signaling pathway
|
|
Nicotine pharmacodynamics pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
|
5HT1 type receptor mediated signaling pathway
|
|
Reactome
|
Dopamine receptors
|
|
G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
|
|
G alpha (i) signalling events
|
|
WikiPathways
|
Hypothetical Network for Drug Addiction
|
|
Monoamine GPCRs
|
|
GPCRs, Class A Rhodopsin-like
|
|
Genes and (Common) Pathways Underlying Drug Addiction
|
|
GPCR ligand binding
|
|
GPCR downstream signaling
|
|
Nicotine Activity on Dopaminergic NeuronsWP722:Serotonin HTR1 Group and FOS Pathway
|
|
SIDS Susceptibility Pathways
|
| References |
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000698) |
|---|
| REF 2 | The effects of umespirone as a potential anxiolytic and antipsychotic agent. Pharmacol Biochem Behav. 1991 Sep;40(1):89-96. |
|---|
