| Drug General Information |
| Drug ID |
D0K6ZT
|
| Former ID |
DNC010332
|
| Drug Name |
2-(2-fluorophenoxy)-3-(piperidin-4-yl)pyridine
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C16H17FN2O
|
| Canonical SMILES |
C1CNCCC1C2=C(N=CC=C2)OC3=CC=CC=C3F
|
| InChI |
1S/C16H17FN2O/c17-14-5-1-2-6-15(14)20-16-13(4-3-9-19-16)12-7-10-18-11-8-12/h1-6,9,12,18H,7-8,10-11H2
|
| InChIKey |
OTTUCFBNHXCUBH-UHFFFAOYSA-N
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| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
5-hydroxytryptamine 1A receptor |
Target Info |
Inhibitor |
[1]
|
|---|
| Sodium-dependent serotonin transporter |
Target Info |
Inhibitor |
[1]
|
| Sodium-dependent noradrenaline transporter |
Target Info |
Inhibitor |
[1]
|
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KEGG Pathway
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cAMP signaling pathway
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Neuroactive ligand-receptor interaction
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Serotonergic synapsehsa04726:Serotonergic synapse
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NetPath Pathway
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TCR Signaling Pathway
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PANTHER Pathway
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Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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5HT1 type receptor mediated signaling pathwayP04373:5HT1 type receptor mediated signaling pathway
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5HT2 type receptor mediated signaling pathway
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5HT3 type receptor mediated signaling pathway
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5HT4 type receptor mediated signaling pathwayP00001:Adrenaline and noradrenaline biosynthesis
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Reactome
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Serotonin receptors
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G alpha (i) signalling eventsR-HSA-442660:Na+/Cl- dependent neurotransmitter transporters
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WikiPathways
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Serotonin HTR1 Group and FOS Pathway
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SIDS Susceptibility Pathways
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Monoamine GPCRs
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GPCRs, Class A Rhodopsin-like
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GPCR ligand binding
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GPCR downstream signalingWP727:Monoamine Transport
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NRF2 pathway
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Synaptic Vesicle Pathway
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Serotonin Transporter ActivityWP727:Monoamine Transport
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Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
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| References |
| REF 1 | Bioorg Med Chem Lett. 2010 Feb 1;20(3):1114-7. Epub 2009 Dec 6.Design, synthesis, and pharmacological evaluation of phenoxy pyridyl derivatives as dual norepinephrine reuptake inhibitors and 5-HT1A partial agonists. |
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