Drug Information

Drug General Information
Drug ID
D0K6ZT
Former ID
DNC010332
Drug Name
2-(2-fluorophenoxy)-3-(piperidin-4-yl)pyridine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530596]
Structure
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2D MOL

3D MOL
Formula
C16H17FN2O
Canonical SMILES
C1CNCCC1C2=C(N=CC=C2)OC3=CC=CC=C3F
InChI
1S/C16H17FN2O/c17-14-5-1-2-6-15(14)20-16-13(4-3-9-19-16)12-7-10-18-11-8-12/h1-6,9,12,18H,7-8,10-11H2
InChIKey
OTTUCFBNHXCUBH-UHFFFAOYSA-N
PubChem Compound ID
44133851
Target and Pathway
Target(s) 5-hydroxytryptamine 1A receptor Target Info Inhibitor [530596]
Sodium-dependent serotonin transporter Target Info Inhibitor [530596]
Sodium-dependent noradrenaline transporter Target Info Inhibitor [530596]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapsehsa04726:Serotonergic synapse
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathwayP04373:5HT1 type receptor mediated signaling pathway
5HT2 type receptor mediated signaling pathway
5HT3 type receptor mediated signaling pathway
5HT4 type receptor mediated signaling pathwayP00001:Adrenaline and noradrenaline biosynthesis
Reactome Serotonin receptors
G alpha (i) signalling eventsR-HSA-442660:Na+/Cl- dependent neurotransmitter transporters
WikiPathways Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP727:Monoamine Transport
NRF2 pathway
Synaptic Vesicle Pathway
Serotonin Transporter ActivityWP727:Monoamine Transport
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
References
Ref 530596Bioorg Med Chem Lett. 2010 Feb 1;20(3):1114-7. Epub 2009 Dec 6.Design, synthesis, and pharmacological evaluation of phenoxy pyridyl derivatives as dual norepinephrine reuptake inhibitors and 5-HT1A partial agonists.
Ref 530596Bioorg Med Chem Lett. 2010 Feb 1;20(3):1114-7. Epub 2009 Dec 6.Design, synthesis, and pharmacological evaluation of phenoxy pyridyl derivatives as dual norepinephrine reuptake inhibitors and 5-HT1A partial agonists.

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