| Drug General Information |
| Drug ID |
D04ZMS
|
| Former ID |
DNC004823
|
| Drug Name |
3-(4-Benzyl-piperidin-1-ylmethyl)-chroman-4-one
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C22H25NO2
|
| Canonical SMILES |
C1CN(CCC1CC2=CC=CC=C2)CC3COC4=CC=CC=C4C3=O
|
| InChI |
1S/C22H25NO2/c24-22-19(16-25-21-9-5-4-8-20(21)22)15-23-12-10-18(11-13-23)14-17-6-2-1-3-7-17/h1-9,18-19H,10-16H2
|
| InChIKey |
ODWZSCLUZWGCOH-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
5-hydroxytryptamine 1A receptor |
Target Info |
Inhibitor |
[1]
|
|---|
| D(2) dopamine receptor |
Target Info |
Inhibitor |
[1]
|
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KEGG Pathway
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cAMP signaling pathway
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Neuroactive ligand-receptor interaction
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Serotonergic synapsehsa04015:Rap1 signaling pathway
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Gap junction
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Dopaminergic synapse
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Parkinson's disease
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Cocaine addiction
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Alcoholism
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PANTHER Pathway
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Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
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Dopamine receptor mediated signaling pathway
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Nicotine pharmacodynamics pathway
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Reactome
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Serotonin receptors
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G alpha (i) signalling eventsR-HSA-390651:Dopamine receptors
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G alpha (i) signalling events
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WikiPathways
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Serotonin HTR1 Group and FOS Pathway
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SIDS Susceptibility Pathways
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Monoamine GPCRs
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GPCRs, Class A Rhodopsin-like
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GPCR ligand binding
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GPCR downstream signalingWP666:Hypothetical Network for Drug Addiction
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Genes and (Common) Pathways Underlying Drug Addiction
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GPCR downstream signaling
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Nicotine Activity on Dopaminergic Neurons
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| References |
| REF 1 | J Med Chem. 2005 Jan 13;48(1):266-73.Synthesis and structure-activity relationships of 1-aralkyl-4-benzylpiperidine and 1-aralkyl-4-benzylpiperazine derivatives as potent sigma ligands. |
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