Target Information
Target General Infomation | |||||
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Target ID |
T58992
|
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Former ID |
TTDS00128
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Target Name |
Delta-type opioid receptor
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Gene Name |
OPRD1
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Synonyms |
DOR-1; Delta opioid receptor; OPRD1
|
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Target Type |
Successful
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Disease | Acute migraine [ICD9: 346; ICD10: G43] | ||||
Acute nonspecific diarrhea; Chronic diarrhea associated with inflammatory bowel disease [ICD10: K50, K60] | |||||
Alcohol use disorders [ICD9: 303; ICD10: F10.2] | |||||
Anxiety disorder [ICD9: 300, 311; ICD10: F32, F40-F42] | |||||
Bladder disease [ICD10: N30-N32] | |||||
Cough [ICD9: 786.2; ICD10: R05] | |||||
Diarrhea-predominant IBS [ICD9: 564.1; ICD10: K58.0] | |||||
Ischemic heart diseases [ICD9: 410-414; ICD10: I20-I25] | |||||
Moderate-to-severe pain [ICD10: R52, G89] | |||||
Major depressive disorder [ICD9: 296.2, 296.3, 710.0; ICD10: F32, F33, M32] | |||||
Overactive bladder disorder [ICD9: 188, 596.51; ICD10: C67, N32.81] | |||||
Pain [ICD9: 338, 356.0, 356.8,780; ICD10: G64, G90.0, R52, G89] | |||||
Premature ejaculation [ICD9: 302.75; ICD10: F52.4] | |||||
Rheumatoid arthritis [ICD9: 710-719, 714; ICD10: M05-M06] | |||||
Substance dependence [ICD10: F10-F19] | |||||
Urinary incontinence [ICD9: 788.3; ICD10: N39.3, N39.4, R32] | |||||
Function |
G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine.
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BioChemical Class |
GPCR rhodopsin
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Target Validation |
T58992
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UniProt ID | |||||
Sequence |
MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVC
AVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELL CKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVG VPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRL RSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAAL HLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTAC TPSDGPGGGAAA |
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Drugs and Mode of Action | |||||
Drug(s) | Butorphanol | Drug Info | Approved | Pain | [538290], [542581] |
Codeine | Drug Info | Approved | Pain | [538268], [539036] | |
Eluxadoline | Drug Info | Approved | Diarrhea-predominant IBS | [542668], [549001] | |
Hydromorphone | Drug Info | Approved | Moderate-to-severe pain | [551871] | |
Loperamide | Drug Info | Approved | Acute nonspecific diarrhea; Chronic diarrhea associated with inflammatory bowel disease | [551871] | |
Oxycodone | Drug Info | Approved | Pain | [538359], [542099] | |
ADL-5747 | Drug Info | Phase 2 | Pain | [522936] | |
ADL-5859 | Drug Info | Phase 2 | Rheumatoid arthritis | [522241] | |
AZD-2327 | Drug Info | Phase 2 | Anxiety disorder | [522445] | |
Carfentanil | Drug Info | Phase 2 | Discovery agent | [524366] | |
Met-enkephalin | Drug Info | Phase 2 | Pain | [521637], [538991] | |
TPM-1/Morphine | Drug Info | Phase 2 | Pain | [548201] | |
Codeine | Drug Info | Phase 1 | Cough | [533409], [539036] | |
MCP-201 | Drug Info | Phase 1 | Pain | [547634] | |
MCP-202 | Drug Info | Phase 1 | Overactive bladder disorder | [547635] | |
BIO-306 | Drug Info | Preclinical | Acute migraine | [536497] | |
SoRI-9409 | Drug Info | Preclinical | Alcohol use disorders | [548793] | |
DPI-3290 | Drug Info | Discontinued in Phase 2 | Pain | [546854] | |
DYNORPHIN A | Drug Info | Discontinued in Phase 2 | Discovery agent | [538995], [546012] | |
TRK-851 | Drug Info | Discontinued in Phase 1 | Cough | [547332] | |
VP004 | Drug Info | Discontinued in Phase 1 | Substance dependence | [548458] | |
BIPHALIN | Drug Info | Terminated | Discovery agent | [546535] | |
BW 373U86 | Drug Info | Terminated | Discovery agent | [545029] | |
LY-255582 | Drug Info | Terminated | Discovery agent | [545880] | |
SB-213698 | Drug Info | Terminated | Discovery agent | [546084] | |
SB-219825 | Drug Info | Terminated | Pain | [546476] | |
SNF-9007 | Drug Info | Terminated | Discovery agent | [546204] | |
Inhibitor | (-)-cyclorphan | Drug Info | [527951] | ||
(-)-eseroline | Drug Info | [551355] | |||
(-)-isoelaeocarpiline | Drug Info | [528442] | |||
(H-Dmt-Tic-Glu-NH-(CH(2))(5)-CO-Dap(6DMN)-NH(2) | Drug Info | [528238] | |||
1,10-bis-(Dmt-Tic-amino)decane | Drug Info | [527916] | |||
1,4-bis-(Dmt-Tic-amino)butane | Drug Info | [527916] | |||
1,6-bis-(Dmt-Tic-amino)hexane | Drug Info | [527916] | |||
1,6-bis-(N,N-dimethyl-Dmt-Tic-NH)hexane | Drug Info | [527916] | |||
1-(1,2-diphenylethyl)-4-phenylpiperidin-4-ol | Drug Info | [528785] | |||
1-(2-ethoxy-1-phenylethyl)-4-phenylpiperidin-4-ol | Drug Info | [528785] | |||
1-(dio-tolylmethyl)-4-phenylpiperidin-4-ol | Drug Info | [528785] | |||
1-benzhydryl-4-(2-fluorophenyl)piperidin-4-ol | Drug Info | [528781] | |||
1-benzhydryl-4-(2-methoxyphenyl)piperidin-4-ol | Drug Info | [528781] | |||
1-benzhydryl-4-(3-fluorophenyl)piperidin-4-ol | Drug Info | [528781] | |||
1-benzhydryl-4-(3-methoxyphenyl)piperidin-4-ol | Drug Info | [528781] | |||
1-benzhydryl-4-(3-phenylpropyl)piperidin-4-ol | Drug Info | [528781] | |||
1-benzhydryl-4-(4-bromophenyl)piperidin-4-ol | Drug Info | [528781] | |||
1-benzhydryl-4-(4-chlorophenyl)piperidin-4-ol | Drug Info | [528781] | |||
1-benzhydryl-4-(4-fluorophenyl)piperidin-4-ol | Drug Info | [528781] | |||
1-benzhydryl-4-(4-methoxyphenyl)piperidin-4-ol | Drug Info | [528781] | |||
1-benzhydryl-4-(benzyloxy)-4-phenylpiperidine | Drug Info | [528785] | |||
1-benzhydryl-4-(furan-2-yl)piperidin-4-ol | Drug Info | [528781] | |||
1-benzhydryl-4-(thiophen-2-yl)piperidin-4-ol | Drug Info | [528781] | |||
1-benzhydryl-4-benzylpiperidin-4-ol | Drug Info | [528781] | |||
1-benzhydryl-4-butylpiperidin-4-ol | Drug Info | [528781] | |||
1-benzhydryl-4-cyclohexylpiperidin-4-ol | Drug Info | [528781] | |||
1-benzhydryl-4-ethoxy-4-phenylpiperidine | Drug Info | [528785] | |||
1-benzhydryl-4-hexylpiperidin-4-ol | Drug Info | [528781] | |||
1-benzhydryl-4-m-tolylpiperidin-4-ol | Drug Info | [528781] | |||
1-benzhydryl-4-methoxy-4-phenylpiperidine | Drug Info | [528785] | |||
1-benzhydryl-4-o-tolylpiperidin-4-ol | Drug Info | [528781] | |||
1-benzhydryl-4-p-tolylpiperidin-4-ol | Drug Info | [528781] | |||
1-benzhydryl-4-phenyl-4-propoxypiperidine | Drug Info | [528785] | |||
1-benzhydryl-4-phenylpiperidin-4-ol | Drug Info | [530052] | |||
1-[3-(3-biphenyl)-(1,2,4-triazol-4-yl) ]-3-phenol | Drug Info | [528288] | |||
1-[3-(4-biphenyl)-(1,2,4-triazol-4-yl) ]-3-phenol | Drug Info | [528288] | |||
14-O-phenylpropylnaltrexone | Drug Info | [529991] | |||
17-(Cyclobutylmethyl)-N-phenylmorphinan-3-amine | Drug Info | [530529] | |||
17-(Cyclopropylmethyl)-N-phenylmorphinan-3-amine | Drug Info | [530529] | |||
17-methyl-4'-methyldihydromorphinone | Drug Info | [528375] | |||
17-Methylmorphinan-3-yl 4-Iodophenyl Carbamate | Drug Info | [530529] | |||
2-Hydroxymethyl-3-hydroxymorphinan | Drug Info | [530529] | |||
3,6-bis(Dmt-Tic-NH-butyl)-2(1H)-pyrazinone | Drug Info | [527916] | |||
3,6-bis(Dmt-Tic-NH-ethyl)-2(1H)-pyrazinone | Drug Info | [527916] | |||
3,6-bis(Dmt-Tic-NH-methyl)-2(1H)-pyrazinone | Drug Info | [527916] | |||
3,6-bis(Dmt-Tic-NH-propyl)-2(1H)-pyrazinone | Drug Info | [527916] | |||
3-desoxy-3-carboxamidonaltrexone | Drug Info | [530013] | |||
4-(4-((phenethylamino)methyl)phenoxy)benzamide | Drug Info | [528996] | |||
4-(p-Tolyl)spiro[chromene-2,4'-piperidine] | Drug Info | [529689] | |||
4-(Spiro[chromene-2,4'-piperidine]-4-yl)benzamide | Drug Info | [530324] | |||
4-(Spiro[chromene-2,4'-piperidine]-4-yl)phenol | Drug Info | [529689] | |||
4-phenyl-1-(1-phenylbutyl)piperidin-4-ol | Drug Info | [528785] | |||
4-phenyl-1-(1-phenylheptyl)piperidin-4-ol | Drug Info | [528785] | |||
4-phenyl-1-(1-phenylhexyl)piperidin-4-ol | Drug Info | [528785] | |||
4-phenyl-1-(1-phenylpentyl)piperidin-4-ol | Drug Info | [528785] | |||
4-phenyl-1-(phenyl(m-tolyl)methyl)piperidin-4-ol | Drug Info | [528785] | |||
4-phenyl-1-(phenyl(o-tolyl)methyl)piperidin-4-ol | Drug Info | [528785] | |||
4-phenyl-1-(phenyl(p-tolyl)methyl)piperidin-4-ol | Drug Info | [528785] | |||
4-phenyl-4-[1H-imidazol-2-yl]-piperidine | Drug Info | [527810] | |||
4-Phenylspiro[chromene-2,4'-piperidine] | Drug Info | [529689] | |||
5-(4-((phenethylamino)methyl)phenoxy)picolinamide | Drug Info | [528996] | |||
6-(2-phenethylisoindolin-5-yloxy)nicotinamide | Drug Info | [529132] | |||
6-(4-((benzylamino)methyl)phenoxy)nicotinamide | Drug Info | [528996] | |||
6-(4-((phenethylamino)methyl)phenoxy)nicotinamide | Drug Info | [529132] | |||
6-(4-(2-(benzylamino)ethyl)phenoxy)nicotinamide | Drug Info | [529132] | |||
6-(4-(3-(benzylamino)propyl)phenoxy)nicotinamide | Drug Info | [528996] | |||
6-(Allyl-methyl-amino)-4,4-diphenyl-heptan-3-ol | Drug Info | [533539] | |||
6-cinnamoyl-N-methylstephasunoline | Drug Info | [530876] | |||
6-cinnamoylhernandine | Drug Info | [530876] | |||
6-desoxonaltrexone | Drug Info | [530013] | |||
6beta-naltrexol HCl | Drug Info | [530077] | |||
8-azabicyclo[3.2.1]octan-3-yloxy-benzamide | Drug Info | [531109] | |||
8-carboxamidocyclazocine | Drug Info | [529429] | |||
AKNADILACTAM | Drug Info | [530876] | |||
AMINOFENTANYL | Drug Info | [528300] | |||
ANALOG OF DYNORPHIN A | Drug Info | [533889] | |||
Antanal 1 | Drug Info | [529704] | |||
Antanal 2 | Drug Info | [529704] | |||
Benzyl derivative of M6G | Drug Info | [527461] | |||
BIPHALIN | Drug Info | [530392] | |||
Bis-((-)-N-propargylmorphinan-3-yl) sebacoylate | Drug Info | [527951] | |||
BUTORPHAN | Drug Info | [530707] | |||
CARBOXYFENTANYL | Drug Info | [529088] | |||
CCDC 710249, HCl salt | Drug Info | [530013] | |||
Cis-H-Tyr-c[D-AllylGly-Gly-Phe-D-Allylgly]-OH | Drug Info | [528875] | |||
Clocinnamox | Drug Info | [529991] | |||
CYCLAZOCINE | Drug Info | [529871] | |||
CYCLORPHAN | Drug Info | [530529] | |||
C[L-mTyr-D-pro-L-Phe-D-trp] | Drug Info | [530160] | |||
C[L-Phe-D-pro-L-mTyr-D-trp] | Drug Info | [530160] | |||
C[L-Phe-D-pro-L-Phe-L-trp] | Drug Info | [530160] | |||
D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2(CTAP) | Drug Info | [533376] | |||
D-Phe-Cys-Tyr-D-Trp-Lys-Thr-Pen-Thr-NH2(CTP) | Drug Info | [533376] | |||
D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2(CTOP) | Drug Info | [533376] | |||
D-PhGly-Cys-Tyr-D-Trp-Lys-Thr-Pen-Thr-NH2 | Drug Info | [533376] | |||
DAMGO | Drug Info | [551220] | |||
Dcp-c[D-Cys-Gly-Phe(pNO2)-D-Cys]NH2 | Drug Info | [528376] | |||
Delta-kappa opioid heterodimer | Drug Info | [527089] | |||
DELTORPHIN | Drug Info | [533972] | |||
DELTORPHIN-II | Drug Info | [531038] | |||
Deprotected cogener of M6G | Drug Info | [527461] | |||
DERMORPHIN | Drug Info | [527931] | |||
Dhp-c[D-Cys-Gly-Phe(pNO2)-D-Cys]NH2 | Drug Info | [528376] | |||
Dimepheptanol | Drug Info | [533539] | |||
Dmt-Pro-3,5Dmp-Phe-NH2 | Drug Info | [528832] | |||
Dmt-Pro-Dmp-Phe-NH2 | Drug Info | [528832] | |||
Dmt-Pro-Dmt-Phe-NH2 | Drug Info | [528832] | |||
Dmt-Pro-Emp-Phe-NH2 | Drug Info | [528832] | |||
Dmt-Pro-Imp-Phe-NH2 | Drug Info | [528832] | |||
Dmt-Pro-Mmp-Phe-NH2 | Drug Info | [528832] | |||
Dmt-Pro-Phe-D-1-Nal-NH2 | Drug Info | [528646] | |||
Dmt-Pro-Phe-D-2-Nal-NH2 | Drug Info | [528646] | |||
Dmt-Pro-Phe-Phe-NH2 | Drug Info | [528832] | |||
Dmt-Pro-Tmp-Phe-NH2 | Drug Info | [528832] | |||
Dmt-Pro-Trp-D-2-Nal-NH2 | Drug Info | [528646] | |||
DPDPE | Drug Info | [551220] | |||
DYNORPHIN A | Drug Info | [533889] | |||
ELAEOCARPENINE | Drug Info | [530705] | |||
ENDOMORPHIN 2 | Drug Info | [531092] | |||
ENDOMORPHIN-1 | Drug Info | [529556] | |||
ETONITAZENE | Drug Info | [531519] | |||
FALCARINDIOL | Drug Info | [529238] | |||
Grandisine C | Drug Info | [528442] | |||
Grandisine D | Drug Info | [528442] | |||
Grandisine F | Drug Info | [528442] | |||
GUANIDINONALTRINDOLE | Drug Info | [526656] | |||
H-2',6'-dimethyltyrosine-Tic-OH | Drug Info | [530447] | |||
H-2',6'-dimethyltyrosine-Tic-Phe-Phe-OH | Drug Info | [530447] | |||
H-Aba-ala-Gly-Phe-leu-OH | Drug Info | [528724] | |||
H-Aba-ala-Gly-Phe-Met-OH | Drug Info | [528724] | |||
H-Aba-Gly-Gly-Phe-Leu-OH | Drug Info | [528724] | |||
H-Aba-ser-Gly-Phe-Leu-Thr-OH | Drug Info | [528724] | |||
H-Apa-ala-Gly-Phe-leu-OH | Drug Info | [528724] | |||
H-Cdp-ala-Gly-Phe-leu-OH | Drug Info | [528724] | |||
H-Cdp-Gly-Gly-Phe-Leu-OH | Drug Info | [528724] | |||
H-Cdp-ser-Gly-Phe-Leu-Thr-OH | Drug Info | [528724] | |||
H-Cpa-c[pen-Gly-Phe-pen]OH | Drug Info | [528724] | |||
H-Cpa-Gly-Gly-Phe-Met-NH2 | Drug Info | [528724] | |||
H-Cpa-Gly-Gly-Phe-Met-OH | Drug Info | [528724] | |||
H-Cxp-ala-Gly-Phe-leu-OH | Drug Info | [528724] | |||
H-D-Phe-c[Cys-Tyr-DTrp-Orn-Thr-Pen]-Thr-NH2 | Drug Info | [529704] | |||
H-D-Tca-c[Cys-Tyr-D-Trp-Arg-Thr-Pen]-Thr-NH2 | Drug Info | [525699] | |||
H-D-Tic-c[Cys-Tyr-D-Trp-Arg-Thr-Pen]-Thr-NH2 | Drug Info | [525699] | |||
H-D-Trp-c[Cys-Tyr-D-Trp-Arg-Thr-Pen]-Thr-NH2 | Drug Info | [525699] | |||
H-Dmt-Aba-Gly-NH-CH2-Bid | Drug Info | [528269] | |||
H-Dmt-Aba-Gly-NH-CH2-Ph | Drug Info | [528269] | |||
H-Dmt-Aba-Gly-NH-Ph | Drug Info | [528269] | |||
H-Dmt-D-Arg(NO2)-Phe-Lys(Z)-NH2 | Drug Info | [527693] | |||
H-Dmt-D-Arg(NO2)-Phe-Lys(Z)-OH | Drug Info | [527693] | |||
H-Dmt-Tic-(2R,3R)-beta-MeCha-Phe-NH2 | Drug Info | [528621] | |||
H-Dmt-Tic-(2R,3R)-beta-MeCha-Phe-OH | Drug Info | [528621] | |||
H-Dmt-Tic-(2R,3S)-beta-MeCha-Phe-NH2 | Drug Info | [528621] | |||
H-Dmt-Tic-(2R,3S)-beta-MeCha-Phe-OH | Drug Info | [528621] | |||
H-Dmt-Tic-(2S,3R)-beta-MeCha-Phe-NH2 | Drug Info | [528621] | |||
H-Dmt-Tic-(2S,3R)-beta-MeCha-Phe-OH | Drug Info | [528621] | |||
H-Dmt-Tic-(2S,3S)-beta-MeCha-Phe-NH2 | Drug Info | [528621] | |||
H-Dmt-Tic-(2S,3S)-beta-MeCha-Phe-OH | Drug Info | [528621] | |||
H-Dmt-Tic-Asp-N(Me)-Ph | Drug Info | [529630] | |||
H-Dmt-Tic-Asp-NH-Bzl | Drug Info | [529630] | |||
H-Dmt-Tic-Asp-NH-Ph | Drug Info | [529630] | |||
H-Dmt-Tic-D-Asp-N(Me)-Ph | Drug Info | [529630] | |||
H-Dmt-Tic-D-Asp-NH-Ph | Drug Info | [529630] | |||
H-Dmt-Tic-Glu-Dap(6DMN)-NH(2) | Drug Info | [528238] | |||
H-Dmt-Tic-Glu-NH-(CH2)5-NH2 | Drug Info | [527332] | |||
H-Dmt-Tic-Glu-NH2 | Drug Info | [527332] | |||
H-Dmt-Tic-Gly-N(Me)-Ph | Drug Info | [529630] | |||
H-Dmt-Tic-Gly-NH-Bzl | Drug Info | [529630] | |||
H-Dmt-Tic-Gly-NH-CH2-Bid | Drug Info | [528269] | |||
H-Dmt-Tic-Gly-NH-Ph | Drug Info | [529630] | |||
H-Dmt-Tic-Lys(Ac)-NH-CH2-Ph | Drug Info | [528411] | |||
H-Dmt-Tic-Lys(Ac)-NH-Ph | Drug Info | [528411] | |||
H-Dmt-Tic-Lys(Z)-NH-CH2-Ph | Drug Info | [528411] | |||
H-Dmt-Tic-Lys(Z)-NH-Ph | Drug Info | [528411] | |||
H-Dmt-Tic-Lys-NH-CH2-Ph | Drug Info | [528411] | |||
H-Dmt-Tic-Lys-NH-Ph | Drug Info | [528411] | |||
H-Dmt-Tic-NH-(CH2)6-NH-Dmt-H | Drug Info | [527758] | |||
H-Dmt-Tic-NH-(CH2)6-NH-Phe-H | Drug Info | [527758] | |||
H-Dmt-Tic-NH-(CH2)6-NH-Tic-H | Drug Info | [527758] | |||
H-Dmt-Tic-NH-(D)-CH[(CH2)4-NH-Z]-Bid | Drug Info | [528411] | |||
H-Dmt-Tic-NH-(R)CH(CH2-COOH)-Bid | Drug Info | [529630] | |||
H-Dmt-Tic-NH-(R)CH(CH2-COOH)-Bid(N1-Me) | Drug Info | [529630] | |||
H-Dmt-Tic-NH-(S)CH(CH2-COOH)-Bid(N1-Me) | Drug Info | [529630] | |||
H-Dmt-Tic-NH-CH2-Boa | Drug Info | [529246] | |||
H-Dmt-Tic-NH-CH2-Bta | Drug Info | [529246] | |||
H-Dmt-Tic-NH-CH2-CH2-NH2 | Drug Info | [529041] | |||
H-Dmt-Tic-NH-CH2-Imid | Drug Info | [529246] | |||
H-Dmt-Tic-NH-CH2-ImidPh | Drug Info | [529246] | |||
H-Dmt-Tic-NH-CH2-Indl | Drug Info | [529246] | |||
H-Dmt-Tic-NH-CH2-Indn | Drug Info | [529246] | |||
H-Dmt-Tic-NH-CH[(CH2)4-NH-Ac]-Bid | Drug Info | [528411] | |||
H-Dmt-Tic-NH-CH[(CH2)4-NH-Z]-Bid | Drug Info | [528411] | |||
H-Dmt-Tic-NH-CH[(CH2)4-NH2]-Bid | Drug Info | [528411] | |||
H-Dmt-Tic-OH | Drug Info | [527916] | |||
H-mCpa-ala-Gly-Phe-leu-OH | Drug Info | [528724] | |||
H-mCpa-Gly-Gly-Phe-Leu-OH | Drug Info | [528724] | |||
H-mCpa-ser-Gly-Phe-Leu-Thr-OH | Drug Info | [528724] | |||
H-Poa-ser-Gly-Phe-Leu-Thr-OH | Drug Info | [528724] | |||
H-Tyr-c[cys-Gly-Phe(p-NO2)-cys]NH2 | Drug Info | [528724] | |||
H-Tyr-c[D-Allylgly-Gly-Phe-D-Allylgly]-OH | Drug Info | [528875] | |||
H-Tyr-c[D-Allylgly-Gly-Phe-D-Allylgly]NH2 | Drug Info | [528692] | |||
H-Tyr-c[D-Allylgly-Gly-Phe-L-Allylgly]NH2 | Drug Info | [528692] | |||
H-Tyr-c[D-Cys-Gly-Phe-D-Cys]NH2 | Drug Info | [528692] | |||
H-Tyr-c[D-Cys-Gly-Phe-L-Cys]NH2 | Drug Info | [528692] | |||
H-Tyr-c[D-Orn-(D or L)Atc-Glu]-NH2 | Drug Info | [528093] | |||
H-Tyr-c[D-Orn-Aic-Glu]-NH2 | Drug Info | [528093] | |||
H-Tyr-c[pen-Gly-Phe-pen]OH | Drug Info | [528724] | |||
H-Tyr-D-Ala-Gly Phe-Pro-Leu-Trp-O-3,5-Bzl(CF3)2 | Drug Info | [529306] | |||
H-Tyr-D-Ala-Gly-Phe-D-Leu | Drug Info | [528853] | |||
H-Tyr-D-Ala-Gly-Phe-NH-NH-(NMe)Phe-Asp-Nle-Trp-Ac | Drug Info | [528058] | |||
H-Tyr-D-Ala-Gly-Phe-NH-NH-D-Phe-D-Asp-D-Nle-Trp-H | Drug Info | [528606] | |||
H-Tyr-D-Ala-Gly-Phe-NH-NH-D-Trp-Nle-Asp-Phe-Bo | Drug Info | [528606] | |||
H-Tyr-D-Ala-Gly-Phe-NH-NH-D-Trp-Nle-Asp-Phe-H | Drug Info | [528606] | |||
H-Tyr-D-Ala-Gly-Phe-NH-NH-Phe-Asp-Nle-D-Trp-Boc | Drug Info | [528058] | |||
H-Tyr-D-Ala-Gly-Phe-NH-NH-Phe-Asp-Nle-D-Trp-H | Drug Info | [528058] | |||
H-Tyr-D-Ala-Gly-Phe-NH-NH-Phe-Asp-Nle-Trp-Ac | Drug Info | [528058] | |||
H-Tyr-D-Ala-Gly-Phe-NH-NH-Phe-Asp-Nle-Trp-Boc | Drug Info | [528058] | |||
H-Tyr-D-Ala-Gly-Phe-NH-NH-Trp-D-Nle-D-Asp-D-Phe-H | Drug Info | [528606] | |||
H-Tyr-D-Ala-Gly-Phe-Pro-Leu-Trp-NH-3,5-Bzl(CF3)2 | Drug Info | [529306] | |||
H-Tyr-D-Ala-Gly-Phe-Pro-Leu-Trp-NH-Bzl | Drug Info | [529306] | |||
H-Tyr-D-Ala-Gly-Phe-Pro-Leu-Trp-NMe-3,5-Bzl(CF3)2 | Drug Info | [529306] | |||
H-Tyr-D-Ala-Gly-Phe-Pro-Leu-Trp-NMe-Bzl | Drug Info | [529306] | |||
H-Tyr-D-Ala-Gly-Phe-Pro-Leu-Trp-O-Bzl | Drug Info | [529306] | |||
H-Tyr-Gly-Gly-Phe-Met-NH2 | Drug Info | [528724] | |||
H-Tyr-Gly-Gly-Phe-Met-OH | Drug Info | [528724] | |||
H-Tyr-NMe-D-Ala-Phe-Sar-NH2 | Drug Info | [529395] | |||
H-Tyr-Pro-Dap(6DMN)-Phe-NH2 | Drug Info | [528238] | |||
H-Tyr-Pro-Phe-Phe-NH-(CH2)5-(C=O)-Dap(6DMN)-NH2 | Drug Info | [528238] | |||
H-Tyr-Pro-Phe-Phe-NH-CH2-CH2-NH Tic Dmt-H | Drug Info | [529041] | |||
H-Tyr-Tic-Cha-Phe-OH | Drug Info | [528621] | |||
H-Tyr-Tic-OH | Drug Info | [530447] | |||
H-Tyr-Tic-Phe-Phe-OH | Drug Info | [528621] | |||
HERKINORIN | Drug Info | [529401] | |||
HTyr-Gly-Gly-Phe-Leu-Arg-Arg-lle-Arg-Pro-LysNH2 | Drug Info | [530428] | |||
ICI-174864 | Drug Info | [528410] | |||
ICI-199441 | Drug Info | [527541] | |||
ISOELAEOCARPINE | Drug Info | [528801] | |||
LOFENTANIL | Drug Info | [533543] | |||
LONGANINE | Drug Info | [530876] | |||
LOPHOCLADINE A | Drug Info | [528165] | |||
LY-255582 | Drug Info | [534631] | |||
M6G thiosaccharide analogue | Drug Info | [527461] | |||
MC-CAM | Drug Info | [530461] | |||
MCL-117 | Drug Info | [527951] | |||
MCL-139 | Drug Info | [527951] | |||
MCL-144 | Drug Info | [530279] | |||
MCL-145 | Drug Info | [527951] | |||
MCL-147 | Drug Info | [528787] | |||
MCL-149 | Drug Info | [528787] | |||
MCL-153 | Drug Info | [530707] | |||
MCL-154 | Drug Info | [530707] | |||
MCL-182 | Drug Info | [528787] | |||
MCL-183 | Drug Info | [528787] | |||
MCL-428 | Drug Info | [528655] | |||
MCL-429 | Drug Info | [528655] | |||
MCL-431 | Drug Info | [528655] | |||
MCL-432 | Drug Info | [528655] | |||
MCL-433 | Drug Info | [528655] | |||
MCL-434 | Drug Info | [528655] | |||
MCL-435 | Drug Info | [528655] | |||
MCL-443 | Drug Info | [528655] | |||
MCL-444 | Drug Info | [528655] | |||
MCL-445 | Drug Info | [528787] | |||
MCL-446 | Drug Info | [528787] | |||
MCL-447 | Drug Info | [528787] | |||
MCL-448 | Drug Info | [528787] | |||
MCL-449 | Drug Info | [528655] | |||
MCL-450 | Drug Info | [528412] | |||
MCL-451 | Drug Info | [528412] | |||
MCL-458 | Drug Info | [528787] | |||
METAZOCINE | Drug Info | [529816] | |||
N-(17-Methylmorphinan-3-yl)-N'-phenylurea | Drug Info | [530529] | |||
N-(4-Iodophenyl)-N'-(17-methylmorphinan-3-yl)urea | Drug Info | [530529] | |||
N-alpha-amidino-Tyr(Me)-Pro-Trp-p-Cl-Phe-NH2 | Drug Info | [528594] | |||
N-alpha-amidino-Tyr(Me)-Pro-Trp-Phe-NH2 | Drug Info | [528594] | |||
N-Benzyl-17-(cyclobutylmethyl)morphinan-3-amine | Drug Info | [530529] | |||
N-Benzyl-17-(cyclopropylmethyl)morphinan-3-amine | Drug Info | [530529] | |||
N-methylstephisoferulin | Drug Info | [530876] | |||
N-methylstephuline | Drug Info | [530876] | |||
Naltrexone-6-alpha-ol | Drug Info | [529816] | |||
Naltrexone-6-beta-ol | Drug Info | [529816] | |||
NORBINALTORPHIMINE | Drug Info | [526656] | |||
O-DESMETHYL TRAMADOL | Drug Info | [529816] | |||
OXYMORPHINDOLE | Drug Info | [529414] | |||
PERIPENTADENINE | Drug Info | [529173] | |||
PHENAZOCINE | Drug Info | [529816] | |||
PROSTEPHABYSSINE | Drug Info | [530876] | |||
RTI-5989-23 | Drug Info | [534631] | |||
RTI-5989-25 | Drug Info | [534631] | |||
RTI-5989-31 | Drug Info | [528947] | |||
SALVINORIN A | Drug Info | [529401] | |||
SB-0304 | Drug Info | [529395] | |||
SB-213698 | Drug Info | [530073] | |||
SN-11 | Drug Info | [530073] | |||
SN-23 | Drug Info | [530073] | |||
SN-28 | Drug Info | [531165] | |||
SNF-9007 | Drug Info | [528193] | |||
SOMATOSTATIN | Drug Info | [533376] | |||
TPM-1/Morphine | Drug Info | [544320] | |||
Trans-H-Tyr-c[D-AllylGly-Gly-Phe-D-Allylgly]-OH | Drug Info | [528875] | |||
Tyr-(NMe)Ala-L-Phe-D-Pro-NH2 | Drug Info | [534004] | |||
Tyr-(R)-Aba-Gly-Phe-NH2 | Drug Info | [529202] | |||
Tyr-(S)-Aba-Gly-Phe-NH2 | Drug Info | [529202] | |||
Tyr-(S)-spiro-Aba-Gly-Phe-NH2 | Drug Info | [529202] | |||
Tyr-D-Ala-Gly-D-Trp-Nle-Asp-Phe-NH2 | Drug Info | [528193] | |||
Tyr-D-Ala-Gly-D-Trp-NMeNle-Asp-Phe-NH2 | Drug Info | [528193] | |||
Tyr-D-Ala-Gly-Phe-Met-NH2 | Drug Info | [530392] | |||
Tyr-D-Ala-Gly-Phe-Met-Pro-Leu-Trp-NH-Bzl | Drug Info | [529724] | |||
Tyr-D-Ala-Gly-Phe-NH-NH-Phe-Asp-NMeNle-D-Trp-Boc | Drug Info | [528058] | |||
Tyr-D-Ala-Gly-Trp-Nle-Asp-Phe-NH2 | Drug Info | [528193] | |||
Tyr-D-Ala-Gly-Trp-NMeNle-Asp-Phe-NH2 | Drug Info | [528193] | |||
Tyr-D-Ala-Phe-Asp-Val-Val-Thr[Beta-D-Glc]-Gly-NH2 | Drug Info | [534460] | |||
Tyr-D-Ala-Phe-Glu-Val-Val-Gly-NH2 | Drug Info | [533971] | |||
Tyr-D-Ala-Phe-Gly-Tyr-Pro-Thr(Beta-D-Glc)-Gly-NH2 | Drug Info | [534460] | |||
Tyr-D-Ala-Phe-Thr(-D-Glc)-Tyr-Pro-Ser-NH2 | Drug Info | [534460] | |||
Tyr-D-Met-Phe-His-Leu-Met-Asp-NH2 | Drug Info | [533971] | |||
Tyr-D-Nle-Gly-D-Trp-Nle-Asp-Phe-NH2 | Drug Info | [528193] | |||
Tyr-D-Nle-Gly-D-Trp-NMeNle-Asp-Phe-NH2 | Drug Info | [528193] | |||
Tyr-D-Nle-Gly-Trp-Nle-Asp-Phe-NH2 | Drug Info | [528193] | |||
Tyr-D-Nle-Gly-Trp-NMeNle-Asp-Phe-NH2 | Drug Info | [528193] | |||
Tyr-D-Phe-Gly-D-Trp-Nle-Asp-Phe-NH2 | Drug Info | [528193] | |||
Tyr-D-Phe-Gly-D-Trp-NMeNle-Asp-Phe-NH2 | Drug Info | [528193] | |||
Tyr-D-Phe-Gly-Trp-Nle-Asp-Phe-NH2 | Drug Info | [528193] | |||
Tyr-D-Phe-Gly-Trp-NMeNle-Asp-Phe-NH2 | Drug Info | [528193] | |||
Tyr-D-Pro-Gly-Trp-NMeNle-Asp-Phe-NH2 | Drug Info | [528193] | |||
Tyr-Gly-Gly-Phe-c(Cys-Arg-Arg-Ile-Cys)-Arg-lys | Drug Info | [533889] | |||
Tyr-Gly-Gly-Phe-leu-c(Cys-Arg-Ile-Arg-Cys)-lys | Drug Info | [533889] | |||
Tyr-Gly-Gly-Trp-NMeNle-Asp-Phe-NH2 | Drug Info | [528193] | |||
Tyr-Pro-3,5Dmp-Phe-NH2 | Drug Info | [528832] | |||
Tyr-Pro-D-Phe-D-Pro-NH2 | Drug Info | [534004] | |||
Tyr-Pro-D-Phe-Pro-NH2 | Drug Info | [534004] | |||
Tyr-Pro-D-Phg-Phe-NH2 | Drug Info | [528190] | |||
Tyr-Pro-Dmp-Phe-NH2 | Drug Info | [528832] | |||
Tyr-Pro-Dmt-Phe-NH2 | Drug Info | [528832] | |||
Tyr-Pro-Emp-Phe-NH2 | Drug Info | [528832] | |||
Tyr-Pro-Gly-Trp-NMeNle-Asp-Phe-NH2 | Drug Info | [528193] | |||
Tyr-Pro-Imp-Phe-NH2 | Drug Info | [528832] | |||
Tyr-Pro-L-(NMe)Phe-D-Pro-NH2 | Drug Info | [534004] | |||
Tyr-Pro-L-(NMe)Phe-Pro-NH2 | Drug Info | [534004] | |||
Tyr-Pro-L-Phe-D-Pro-NH2 | Drug Info | [534004] | |||
Tyr-Pro-L-Phe-Pro-NH2 | Drug Info | [534004] | |||
Tyr-Pro-Mmp-Phe-NH | Drug Info | [528832] | |||
Tyr-Pro-Phe-Phe-N(CH3)2 | Drug Info | [529480] | |||
Tyr-Pro-Phe-Phe-NHCH3 | Drug Info | [529480] | |||
Tyr-Pro-Phe-Phe-NHNH2 | Drug Info | [529480] | |||
Tyr-Pro-Phe-Phe-OC(CH3)3 | Drug Info | [529480] | |||
Tyr-Pro-Phe-Phe-OCH2CH3 | Drug Info | [529480] | |||
Tyr-Pro-Phe-Phe-OCH2OH | Drug Info | [529480] | |||
Tyr-Pro-Phe-Phe-OCH3 | Drug Info | [529480] | |||
Tyr-Pro-Tmp-Phe-NH | Drug Info | [528832] | |||
UFP-502 | Drug Info | [531038] | |||
UFP-512 | Drug Info | [531038] | |||
[Dcp1]Dyn A(1-11)-NH2 | Drug Info | [528376] | |||
[Leu5]enkephalin | Drug Info | [530780] | |||
Agonist | 3-Methylfentanyl | Drug Info | [551402] | ||
3-Methylthiofentanyl | Drug Info | [551408] | |||
ADL-5747 | Drug Info | [543762] | |||
ADL-5859 | Drug Info | [543762] | |||
ARD-412 | Drug Info | [543762] | |||
AZD-2327 | Drug Info | [531414] | |||
BBI-11008 | Drug Info | [543762] | |||
Beta-endorphin | Drug Info | [537660] | |||
BIO-306 | Drug Info | [536497] | |||
Butorphanol | Drug Info | [536098] | |||
BW 373U86 | Drug Info | [535207] | |||
Carfentanil | Drug Info | [551406] | |||
Codeine | Drug Info | [536098] | |||
DADLE | Drug Info | [535092] | |||
Dihydromorphine | Drug Info | [551379] | |||
Dimethylthiambutene | Drug Info | [551393] | |||
DPI-221 | Drug Info | [543762] | |||
DPI-3290 | Drug Info | [525347] | |||
DSLET | Drug Info | [543762] | |||
DSTBULET | Drug Info | [533358] | |||
dynorphin B | Drug Info | [543762] | |||
ethyketazocine | Drug Info | [534018] | |||
ethylketocyclazocine | Drug Info | [543762] | |||
Etorphine | Drug Info | [535235] | |||
Leu-enkephalin | Drug Info | [535152] | |||
MCP-201 | Drug Info | [550920] | |||
MCP-202 | Drug Info | [547636] | |||
MCP-203 | Drug Info | [543762] | |||
MCP-204 | Drug Info | [543762] | |||
MCP-205 | Drug Info | [543762] | |||
Met-enkephalin | Drug Info | [537870] | |||
normorphine | Drug Info | [543762] | |||
NRP290 | Drug Info | [543762] | |||
Oxycodone | Drug Info | [536427] | |||
SB 227122 | Drug Info | [534953] | |||
SNC-80 | Drug Info | [534994], [535449] | |||
Tonazocine mesylate | Drug Info | [534994] | |||
[3H]diprenorphine | Drug Info | [543762] | |||
Antagonist | 7-benzylidenenaltrexone | Drug Info | [535501] | ||
CTAP | Drug Info | [543762] | |||
Diprenorphine | Drug Info | [551387] | |||
ICI 154129 | Drug Info | [537722] | |||
naltriben | Drug Info | [529508] | |||
Naltrindole | Drug Info | [535501] | |||
quadazocine | Drug Info | [543762] | |||
SoRI-9409 | Drug Info | [526028] | |||
TIP | Drug Info | [534987] | |||
TIPP | Drug Info | [534987] | |||
TIPPpsi | Drug Info | [533937] | |||
TRK-851 | Drug Info | [529642], [551871] | |||
[3H]naltriben | Drug Info | [534682] | |||
[3H]naltrindole | Drug Info | [526730] | |||
Modulator | Eluxadoline | Drug Info | |||
SB-219825 | Drug Info | [526061] | |||
Binder | Hydromorphone | Drug Info | [535919] | ||
Loperamide | Drug Info | [537797] | |||
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM) | |||||
TEP | EXP Info | ||||
Pathways | |||||
KEGG Pathway | cGMP-PKG signaling pathway | ||||
Sphingolipid signaling pathway | |||||
Neuroactive ligand-receptor interaction | |||||
PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||||
Enkephalin release | |||||
Opioid proenkephalin pathway | |||||
Opioid proopiomelanocortin pathway | |||||
Reactome | Peptide ligand-binding receptors | ||||
G alpha (i) signalling events | |||||
WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
Peptide GPCRs | |||||
GPCR ligand binding | |||||
GPCR downstream signaling | |||||
References | |||||
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Ref 539036 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1673). | ||||
Ref 542099 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7093). | ||||
Ref 542581 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7591). | ||||
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Ref 525347 | DPI-3290 [(+)-3-((alpha-R)-alpha-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N-(3-fluorophenyl)-N-methylbenzamide]. II. A mixed opioid agonist with potent antinociceptive activity and limited effects on respiratory function. J Pharmacol Exp Ther. 2003 Dec;307(3):1227-33. Epub 2003 Oct 8. | ||||
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Ref 527461 | Bioorg Med Chem Lett. 2005 Mar 15;15(6):1583-6.Synthesis and in vitro biological evaluation of a carbon glycoside analogue of morphine-6-glucuronide. | ||||
Ref 527541 | Bioorg Med Chem Lett. 2005 May 16;15(10):2647-52.Arylacetamide kappa opioid receptor agonists with reduced cytochrome P450 2D6 inhibitory activity. | ||||
Ref 527693 | J Med Chem. 2005 Aug 25;48(17):5608-11.From the potent and selective mu opioid receptor agonist H-Dmt-d-Arg-Phe-Lys-NH(2) to the potent delta antagonist H-Dmt-Tic-Phe-Lys(Z)-OH. | ||||
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