Drug Information

Drug General Information
Drug ID
D09BYD
Former ID
DNC007728
Drug Name
1-benzhydryl-4-o-tolylpiperidin-4-ol
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528781]
Structure
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2D MOL

3D MOL
Formula
C25H27NO
Canonical SMILES
CC1=CC=CC=C1C2(CCN(CC2)C(C3=CC=CC=C3)C4=CC=CC=C4)O
InChI
1S/C25H27NO/c1-20-10-8-9-15-23(20)25(27)16-18-26(19-17-25)24(21-11-4-2-5-12-21)22-13-6-3-7-14-22/h2-15,24,27H,16-19H2,1H3
InChIKey
WOOXDHAITFKPDQ-UHFFFAOYSA-N
PubChem Compound ID
20481138
Target and Pathway
Target(s) Delta-type opioid receptor Target Info Inhibitor [528781]
Kappa-type opioid receptor Target Info Inhibitor [528781]
Mu-type opioid receptor Target Info Inhibitor [528781]
Nociceptin receptor Target Info Inhibitor [528781]
KEGG Pathway cGMP-PKG signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interactionhsa04080:Neuroactive ligand-receptor interactionhsa04080:Neuroactive ligand-receptor interaction
Estrogen signaling pathway
Morphine addictionhsa04080:Neuroactive ligand-receptor interaction
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Enkephalin release
Opioid proenkephalin pathway
Opioid proopiomelanocortin pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Opioid prodynorphin pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Enkephalin releaseP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Pathway Interaction Database IL4-mediated signaling events
Reactome Peptide ligand-binding receptors
G alpha (i) signalling eventsR-HSA-375276:Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
GPCR downstream signalingWP69:TCR Signaling Pathway
Opioid Signalling
GPCR downstream signaling
References
Ref 528781Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2.
Ref 528781Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2.

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