Drug Information

Drug General Information
Drug ID
D0TN0D
Former ID
DNC008747
Drug Name
METAZOCINE
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529816]
Structure
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2D MOL

3D MOL
Formula
C15H21NO
Canonical SMILES
CC1C2CC3=C(C1(CCN2C)C)C=C(C=C3)O
InChI
1S/C15H21NO/c1-10-14-8-11-4-5-12(17)9-13(11)15(10,2)6-7-16(14)3/h4-5,9-10,14,17H,6-8H2,1-3H3
InChIKey
YGSVZRIZCHZUHB-UHFFFAOYSA-N
CAS Number
CAS 3734-52-9
PubChem Compound ID
62518
PubChem Substance ID
226693, 486200, 5392777, 8188110, 10520681, 11409234, 15121674, 43119625, 47440737, 47960191, 49991676, 49991678, 57314727, 78611269, 103205923, 103937861, 104325991, 117617120, 126422714, 126433873, 129793497, 135020187, 137248647, 143243146, 179294062, 226414221, 241076244, 249778009, 249948677
Target and Pathway
Target(s) Delta-type opioid receptor Target Info Inhibitor [529816]
Kappa-type opioid receptor Target Info Inhibitor [529816]
Mu-type opioid receptor Target Info Inhibitor [533571]
KEGG Pathway cGMP-PKG signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interactionhsa04080:Neuroactive ligand-receptor interactionhsa04080:Neuroactive ligand-receptor interaction
Estrogen signaling pathway
Morphine addiction
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Enkephalin release
Opioid proenkephalin pathway
Opioid proopiomelanocortin pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Opioid prodynorphin pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Pathway Interaction Database IL4-mediated signaling events
Reactome Peptide ligand-binding receptors
G alpha (i) signalling eventsR-HSA-375276:Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
GPCR downstream signalingWP69:TCR Signaling Pathway
Opioid Signalling
GPCR downstream signaling
References
Ref 529816Bioorg Med Chem Lett. 2009 Jan 1;19(1):203-8. Epub 2008 Nov 7.Syntheses and opioid receptor binding properties of carboxamido-substituted opioids.
Ref 529816Bioorg Med Chem Lett. 2009 Jan 1;19(1):203-8. Epub 2008 Nov 7.Syntheses and opioid receptor binding properties of carboxamido-substituted opioids.
Ref 533571J Med Chem. 1982 Dec;25(12):1423-7.Synthesis and biological evaluation of a metazocine-containing enkephalinamide. Evidence for nonidentical roles of the tyramine moiety in opiates and opioid peptides.

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