| Drug General Information |
| Drug ID |
D06EXA
|
| Former ID |
DNC005337
|
| Drug Name |
SALVINORIN A
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C23H28O8
|
| InChI |
InChI=1S/C23H28O8/c1-12(24)30-16-9-15(20(26)28-4)22(2)7-5-14-21(27)31-17(13-6-8-29-11-13)10-23(14,3)19(22)18(16)25/h6,8,11,14-17,19H,5,7,9-10H2,1-4H3/t14-,15-,16-,17-,19-,22-,23-/m0/s1
|
| InChIKey |
OBSYBRPAKCASQB-AGQYDFLVSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
841714, 10242083, 16381046, 24899776, 29307586, 47437902, 50067596, 50111292, 57342629, 78263362, 103457931, 104045748, 104368418, 121501581, 134221828, 134342542, 135085570, 135652714, 137248535, 143385099, 160711073, 162223660, 163311939, 170485795, 175611615, 177748824, 198941395, 224003872, 226424572, 241146906, 246472304
|
| Target and Pathway |
| Target(s) |
Mu-type opioid receptor |
Target Info |
Inhibitor |
[2]
|
|---|
| Delta-type opioid receptor |
Target Info |
Inhibitor |
[2]
|
| Kappa-type opioid receptor |
Target Info |
Inhibitor |
[3]
|
|
KEGG Pathway
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Neuroactive ligand-receptor interaction
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Estrogen signaling pathway
|
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Morphine addictionhsa04022:cGMP-PKG signaling pathway
|
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Sphingolipid signaling pathway
|
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Neuroactive ligand-receptor interactionhsa04080:Neuroactive ligand-receptor interaction
|
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NetPath Pathway
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TCR Signaling Pathway
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PANTHER Pathway
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Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
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Enkephalin releaseP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Enkephalin release
|
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Opioid proenkephalin pathway
|
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Opioid proopiomelanocortin pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
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Opioid prodynorphin pathway
|
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Pathway Interaction Database
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IL4-mediated signaling events
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Reactome
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Peptide ligand-binding receptors
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G alpha (i) signalling eventsR-HSA-375276:Peptide ligand-binding receptors
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G alpha (i) signalling events
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WikiPathways
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TCR Signaling Pathway
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GPCRs, Class A Rhodopsin-like
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Peptide GPCRs
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Opioid Signalling
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GPCR ligand binding
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GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
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GPCR downstream signaling
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| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1666). |
|---|
| REF 2 | J Med Chem. 2008 Apr 24;51(8):2421-31. Epub 2008 Apr 2.Herkinorin analogues with differential beta-arrestin-2 interactions. |
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| REF 3 | J Med Chem. 2008 Mar 27;51(6):1824-30. Epub 2008 Feb 23.Toward a structure-based model of salvinorin A recognition of the kappa-opioid receptor. |
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