| Drug General Information |
| Drug ID |
D0U3UM
|
| Former ID |
DNC012814
|
| Drug Name |
ETONITAZENE
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C22H28N4O3
|
| InChI |
InChI=1S/C22H28N4O3/c1-4-24(5-2)13-14-25-21-12-9-18(26(27)28)16-20(21)23-22(25)15-17-7-10-19(11-8-17)29-6-3/h7-12,16H,4-6,13-15H2,1-3H3
|
| InChIKey |
PXDBZSCGSQSKST-UHFFFAOYSA-N
|
| CAS Number |
CAS 911-65-9
|
| PubChem Compound ID |
|
| PubChem Substance ID |
6689003, 8160151, 15054622, 29281627, 46508885, 47434902, 48329113, 49882799, 50309062, 57328161, 85209419, 103285455, 103925881, 104331902, 117383265, 126409156, 127331490, 127331491, 127331492, 127331493, 127331494, 128980963, 134224012, 134350019, 134979734, 135650245, 137248664, 144206383, 160964721, 179293665, 198964317, 224204224, 226413319, 241164679, 249950794
|
| Target and Pathway |
| Target(s) |
Kappa-type opioid receptor |
Target Info |
Inhibitor |
[2]
|
|---|
| Delta-type opioid receptor |
Target Info |
Inhibitor |
[2]
|
| Mu-type opioid receptor |
Target Info |
Inhibitor |
[3]
|
|
KEGG Pathway
|
Neuroactive ligand-receptor interactionhsa04022:cGMP-PKG signaling pathway
|
|
Sphingolipid signaling pathway
|
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Neuroactive ligand-receptor interactionhsa04080:Neuroactive ligand-receptor interaction
|
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Estrogen signaling pathway
|
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Morphine addiction
|
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NetPath Pathway
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TCR Signaling Pathway
|
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PANTHER Pathway
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Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
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Opioid prodynorphin pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
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Enkephalin release
|
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Opioid proenkephalin pathway
|
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Opioid proopiomelanocortin pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
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Pathway Interaction Database
|
IL4-mediated signaling events
|
|
Reactome
|
Peptide ligand-binding receptors
|
|
G alpha (i) signalling eventsR-HSA-375276:Peptide ligand-binding receptors
|
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G alpha (i) signalling events
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WikiPathways
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GPCRs, Class A Rhodopsin-like
|
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Peptide GPCRs
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GPCR ligand binding
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GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
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GPCR downstream signalingWP69:TCR Signaling Pathway
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Opioid Signalling
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GPCR downstream signaling
|
| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1624). |
|---|
| REF 2 | J Med Chem. 1990 Sep;33(9):2456-64.Photoactivatable opiate derivatives as irreversible probes of the mu-opioid receptor. |
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| REF 3 | Eur J Med Chem. 2008 Nov;43(11):2307-15. Epub 2008 Feb 29.Ligand binding to nucleic acids and proteins: Does selectivity increase with strength?. |
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