Drug Information

Drug General Information
Drug ID
D04JHN
Former ID
DAP000472
Drug Name
Hydromorphone
Synonyms
DiMo; Dihydromorfinon; Dihydromorphinone; Dilaudid; Dimorphone; Hidromorfona; Hydromorfona; Hydromorphon; Hydromorphonum; Idromorfone; Laudacon; Laudicon; Novolaudon; Dihydromorfinon [Czech]; Dilaudid Oros; Hydromorfona [Spanish]; Hydromorphone HCL; Idromorfone [DCIT]; Dilaudid (TN); Dilaudid-hp; Hidromorfona [INN-Spanish]; Hydromorphone (INN); Hydromorphone [INN:BAN]; Hydromorphonum [INN-Latin]; Palladone (TN); Palladone SR (TN); Morphinan-6-one, 4,5alpha-epoxy-3-hydroxy-17-methyl-(8CI); (-)-(5R)-4,5-Epoxy-3-hydroxy-9alpha-methylmorphinan-6-one; (-)-Hydromorphone; (5alpha)-3-hydroxy-17-methyl-4,5-epoxymorphinan-6-one; 3-hydroxy-17-methyl-4,5alpha-epoxymorphinan-6-one; 4,5-Epoxy-3-hydroxy-17-methylmorphinan-6-one; 4,5alpha-Epoxy-3-hydroxy-17-methyl-6-morphinanone; 6-Deoxy-7,8-dihydro-6-oxomorphine; 7,8-Dihydromorphinone
Drug Type
Small molecular drug
Indication Moderate-to-severe pain [ICD10:R52, G89] Approved [551871]
Therapeutic Class
Analgesics
Company
Knoll
Structure
Download
2D MOL

3D MOL
Formula
C17H19NO3
InChI
InChI=1S/C17H19NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2,4,10-11,16,19H,3,5-8H2,1H3/t10-,11+,16-,17-/m0/s1
InChIKey
WVLOADHCBXTIJK-YNHQPCIGSA-N
CAS Number
CAS 466-99-9
PubChem Compound ID
5284570
PubChem Substance ID
9254, 81990, 7979546, 11039353, 14751077, 14873177, 39317885, 46508700, 48416092, 49993162, 50070721, 56394822, 57359121, 77568926, 96024740, 103557031, 104098728, 129640116, 134222944, 134337767, 134974682, 137005111, 139157539, 160963675, 175268533, 178103661, 179116727, 184536600, 198992261, 223798795, 226394766, 250134622, 252350812
ChEBI ID
ChEBI:5790
SuperDrug ATC ID
N02AA03
SuperDrug CAS ID
cas=000466999
Target and Pathway
Target(s) Delta-type opioid receptor Target Info Binder [535919]
KEGG Pathway cGMP-PKG signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interaction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Enkephalin release
Opioid proenkephalin pathway
Opioid proopiomelanocortin pathway
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 535919Identification of opioid ligands possessing mixed micro agonist/delta antagonist activity among pyridomorphinans derived from naloxone, oxymorphone, and hydromorphone [correction of hydropmorphone]. J Med Chem. 2004 Mar 11;47(6):1400-12.

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