Drug General Information
Drug ID
D0B7GU
Former ID
DNC003299
Drug Name
Dihydromorphine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538993]
Structure
Download
2D MOL

3D MOL

Formula
C17H21NO3
InChI
InChI=1S/C17H21NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2,4,10-11,13,16,19-20H,3,5-8H2,1H3/t10-,11+,13-,16-,17-/m0/s1
InChIKey
IJVCSMSMFSCRME-KBQPJGBKSA-N
CAS Number
CAS 509-60-4
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Mu-type opioid receptor Target Info Agonist [551379]
Kappa-type opioid receptor Target Info Agonist [551379]
Corticotropin-lipotropin Target Info Agonist [551379]
Delta-type opioid receptor Target Info Agonist [551379]
KEGG Pathway Neuroactive ligand-receptor interaction
Estrogen signaling pathway
Morphine addictionhsa04080:Neuroactive ligand-receptor interactionhsa04916:Melanogenesis
Adipocytokine signaling pathwayhsa04022:cGMP-PKG signaling pathway
Sphingolipid signaling pathway
NetPath Pathway TCR Signaling PathwayNetPath_2:AndrogenReceptor Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Enkephalin releaseP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Opioid prodynorphin pathwayP04380:Cortocotropin releasing factor receptor signaling pathway
Opioid proopiomelanocortin pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Enkephalin release
Opioid proenkephalin pathway
Opioid proopiomelanocortin pathway
Pathway Interaction Database IL4-mediated signaling eventsreg_gr_pathway:Glucocorticoid receptor regulatory network
Syndecan-3-mediated signaling events
PathWhiz Pathway Corticotropin Activation of Cortisol Production
Reactome Peptide ligand-binding receptors
G alpha (i) signalling eventsR-HSA-375276:Peptide ligand-binding receptors
G alpha (i) signalling eventsR-HSA-193048:Androgen biosynthesis
Glucocorticoid biosynthesis
Endogenous sterols
G alpha (s) signalling events
G alpha (i) signalling events
WikiPathways TCR Signaling Pathway
GPCRs, Class A Rhodopsin-like
Peptide GPCRs
Opioid Signalling
GPCR ligand binding
GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
GPCR downstream signalingWP2749:Metabolism of steroid hormones and vitamin D
Metabolism of amino acids and derivatives
Peptide hormone biosynthesis
Corticotropin-releasing hormone
Phase 1 - Functionalization of compounds
GPCR downstream signaling
References
Ref 538993(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1616).
Ref 551379Opiate receptor binding properties of morphine-, dihydromorphine-, and codeine 6-O-sulfate ester congeners. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4291-5. Epub 2006 Jun 13.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.