Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T62912
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| Former ID |
TTDR00261
|
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| Target Name |
Corticotropin-lipotropin
|
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| Gene Name |
POMC
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| Synonyms |
Pro-opiomelanocortin; POMC
|
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| Target Type |
Research
|
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| Function |
Beta-endorphin and Met-enkephalin are endogenous opiates.
|
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| UniProt ID | |||||
| Sequence |
MPRSCCSRSGALLLALLLQASMEVRGWCLESSQCQDLTTESNLLECIRACKPDLSAETPM
FPGNGDEQPLTENPRKYVMGHFRWDRFGRRNSSSSGSSGAGQKREDVSAGEDCGPLPEGG PEPRSDGAKPGPREGKRSYSMEHFRWGKPVGKKRRPVKVYPNGAEDESAEAFPLEFKREL TGQRLREGDGPDGPADDGAGAQADLEHSLLVAAEKKDEGPYRMEHFRWGSPPKDKRYGGF MTSEKSQTPLVTLFKNAIIKNAYKKGE |
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| Agonist | Dihydromorphine | Drug Info | [1] | ||
| Pathways | |||||
| KEGG Pathway | Melanogenesis | ||||
| Adipocytokine signaling pathway | |||||
| NetPath Pathway | AndrogenReceptor Signaling Pathway | ||||
| PANTHER Pathway | Cortocotropin releasing factor receptor signaling pathway | ||||
| Opioid proopiomelanocortin pathway | |||||
| Pathway Interaction Database | Glucocorticoid receptor regulatory network | ||||
| Syndecan-3-mediated signaling events | |||||
| PathWhiz Pathway | Corticotropin Activation of Cortisol Production | ||||
| Reactome | Androgen biosynthesis | ||||
| Glucocorticoid biosynthesis | |||||
| Endogenous sterols | |||||
| Peptide ligand-binding receptors | |||||
| G alpha (s) signalling events | |||||
| G alpha (i) signalling events | |||||
| WikiPathways | Metabolism of steroid hormones and vitamin D | ||||
| Metabolism of amino acids and derivatives | |||||
| Peptide hormone biosynthesis | |||||
| Corticotropin-releasing hormone | |||||
| Opioid Signalling | |||||
| Phase 1 - Functionalization of compounds | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Opiate receptor binding properties of morphine-, dihydromorphine-, and codeine 6-O-sulfate ester congeners. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4291-5. Epub 2006 Jun 13. | ||||
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