| Drug General Information |
| Drug ID |
D00HIG
|
| Former ID |
DNC003325
|
| Drug Name |
3-Methylthiofentanyl
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C21H28N2OS
|
| Canonical SMILES |
CCC(=O)N(C1CCN(CC1C)CCC2=CC=CS2)C3=CC=CC=C3
|
| InChI |
1S/C21H28N2OS/c1-3-21(24)23(18-8-5-4-6-9-18)20-12-14-22(16-17(20)2)13-11-19-10-7-15-25-19/h4-10,15,17,20H,3,11-14,16H2,1-2H3
|
| InChIKey |
SRARDYUHGVMEQI-UHFFFAOYSA-N
|
| CAS Number |
CAS 86052-04-2
|
| PubChem Compound ID |
|
| PubChem Substance ID |
43119429, 46506995, 78846170, 87218454, 87246623, 104325415, 117568251, 135020144, 135770465, 137237333, 160964706, 164762907, 175443465, 227922902, 242576424
|
| Target and Pathway |
| Target(s) |
Mu-type opioid receptor |
Target Info |
Agonist |
[1]
|
|---|
| Kappa-type opioid receptor |
Target Info |
Agonist |
[1]
|
| Delta-type opioid receptor |
Target Info |
Agonist |
[1]
|
|
KEGG Pathway
|
Neuroactive ligand-receptor interaction
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Estrogen signaling pathway
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Morphine addictionhsa04080:Neuroactive ligand-receptor interactionhsa04022:cGMP-PKG signaling pathway
|
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Sphingolipid signaling pathway
|
|
NetPath Pathway
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TCR Signaling Pathway
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PANTHER Pathway
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Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
|
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Enkephalin releaseP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Opioid prodynorphin pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
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Enkephalin release
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Opioid proenkephalin pathway
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Opioid proopiomelanocortin pathway
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Pathway Interaction Database
|
IL4-mediated signaling events
|
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Reactome
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Peptide ligand-binding receptors
|
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G alpha (i) signalling eventsR-HSA-375276:Peptide ligand-binding receptors
|
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G alpha (i) signalling events
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WikiPathways
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TCR Signaling Pathway
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GPCRs, Class A Rhodopsin-like
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Peptide GPCRs
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Opioid Signalling
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GPCR ligand binding
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GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
|
|
GPCR downstream signaling
|
| References |
| REF 1 | You HJ, Colpaert FC, Arendt-Nielsen L: The novel analgesic and high-efficacy 5-HT1A receptor agonist F 13640 inhibits nociceptive responses, wind-up, and after-discharges in spinal neurons and withdrawal reflexes. Exp Neurol. 2005 Jan;191(1):174-83. |
|---|
