Drug Information
Drug General Information | |||||
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Drug ID |
D05ANN
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Former ID |
DIB020489
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Drug Name |
naltriben
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Synonyms |
naltrindole benzofuran; naltriben
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [539014] | ||
Structure |
Download2D MOL |
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Formula |
C26H25NO4
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InChI |
InChI=1S/C26H25NO4/c28-18-8-7-15-11-20-26(29)12-17-16-3-1-2-4-19(16)30-22(17)24-25(26,21(15)23(18)31-24)9-10-27(20)13-14-5-6-14/h1-4,7-8,14,20,24,28-29H,5-6,9-13H2/t20-,24+,25+,26-/m1/s1
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InChIKey |
ZHVWWEYETMPAMX-IFKAHUTRSA-N
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PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | Mu-type opioid receptor | Target Info | Antagonist | [543764] | |
Delta-type opioid receptor | Target Info | Antagonist | [529508] | ||
Kappa-type opioid receptor | Target Info | Antagonist | [543763] | ||
NetPath Pathway | TCR Signaling Pathway | ||||
PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||||
Enkephalin releaseP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||||
Enkephalin release | |||||
Opioid proenkephalin pathway | |||||
Opioid proopiomelanocortin pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||||
Opioid prodynorphin pathway | |||||
Pathway Interaction Database | IL4-mediated signaling events | ||||
References | |||||
Ref 529508 | Differential antagonism of delta opioid agonists by naltrindole and its benzofuran analog (NTB) in mice: evidence for delta opioid receptor subtypes. J Pharmacol Exp Ther. 1991 May;257(2):676-80. | ||||
Ref 543763 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 318). | ||||
Ref 543764 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 319). |
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