| Drug General Information |
| Drug ID |
D0H3GI
|
| Former ID |
DNC008941
|
| Drug Name |
4-(p-Tolyl)spiro[chromene-2,4'-piperidine]
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C20H21NO
|
| Canonical SMILES |
CC1=CC=C(C=C1)C2=CC3(CCNCC3)OC4=CC=CC=C42
|
| InChI |
1S/C20H21NO/c1-15-6-8-16(9-7-15)18-14-20(10-12-21-13-11-20)22-19-5-3-2-4-17(18)19/h2-9,14,21H,10-13H2,1H3
|
| InChIKey |
YDXKUUFNKUXOBE-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Kappa-type opioid receptor |
Target Info |
Inhibitor |
[1]
|
|---|
| Delta-type opioid receptor |
Target Info |
Inhibitor |
[1]
|
| Potassium voltage-gated channel subfamily H member 2 |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
Neuroactive ligand-receptor interactionhsa04022:cGMP-PKG signaling pathway
|
|
Sphingolipid signaling pathway
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Neuroactive ligand-receptor interaction
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PANTHER Pathway
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Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
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Opioid prodynorphin pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Enkephalin release
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Opioid proenkephalin pathway
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Opioid proopiomelanocortin pathway
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PathWhiz Pathway
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Muscle/Heart Contraction
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|
Reactome
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Peptide ligand-binding receptors
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G alpha (i) signalling eventsR-HSA-375276:Peptide ligand-binding receptors
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G alpha (i) signalling eventsR-HSA-1296072:Voltage gated Potassium channels
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WikiPathways
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GPCRs, Class A Rhodopsin-like
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Peptide GPCRs
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GPCR ligand binding
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GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
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GPCR downstream signalingWP706:SIDS Susceptibility Pathways
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Hematopoietic Stem Cell Differentiation
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Potassium Channels
|
| References |
| REF 1 | J Med Chem. 2008 Oct 9;51(19):5893-6. Epub 2008 Sep 13.Potent, orally bioavailable delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-4-(5-hydroxyspiro[chromene-2,4'-piperidine]-4-yl)benzamide (ADL5859). |
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