| Drug General Information |
| Drug ID |
D08YUP
|
| Former ID |
DNC012751
|
| Drug Name |
SB-213698
|
| Synonyms |
TAN-67
|
| Indication |
Discovery agent
|
Terminated |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Canonical SMILES |
CN1CCC2(CC3=NC4=CC=CC=C4C=C3CC2C1)C5=CC(=CC=C5)O
|
| InChI |
1S/C23H24N2O/c1-25-10-9-23(18-6-4-7-20(26)13-18)14-22-17(12-19(23)15-25)11-16-5-2-3-8-21(16)24-22/h2-8,11,13,19,26H,9-10,12,14-15H2,1H3/t19-,23+/m1/s1
|
| InChIKey |
LEPBHAAYNPPRRA-XXBNENTESA-N
|
| Target and Pathway |
| Target(s) |
Mu-type opioid receptor |
Target Info |
Inhibitor |
[2]
|
|---|
| Kappa-type opioid receptor |
Target Info |
Inhibitor |
[2]
|
| Delta-type opioid receptor |
Target Info |
Inhibitor |
[2]
|
|
KEGG Pathway
|
Neuroactive ligand-receptor interaction
|
|
Estrogen signaling pathway
|
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Morphine addictionhsa04080:Neuroactive ligand-receptor interactionhsa04022:cGMP-PKG signaling pathway
|
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Sphingolipid signaling pathway
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NetPath Pathway
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TCR Signaling Pathway
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PANTHER Pathway
|
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
|
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Enkephalin releaseP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
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Opioid prodynorphin pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
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Enkephalin release
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Opioid proenkephalin pathway
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Opioid proopiomelanocortin pathway
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Pathway Interaction Database
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IL4-mediated signaling events
|
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Reactome
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Peptide ligand-binding receptors
|
|
G alpha (i) signalling eventsR-HSA-375276:Peptide ligand-binding receptors
|
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G alpha (i) signalling events
|
|
WikiPathways
|
TCR Signaling Pathway
|
|
GPCRs, Class A Rhodopsin-like
|
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Peptide GPCRs
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Opioid Signalling
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GPCR ligand binding
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GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
|
|
GPCR downstream signaling
|
| References |
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006271) |
|---|
| REF 2 | Bioorg Med Chem Lett. 2009 May 15;19(10):2792-5. Epub 2009 Mar 26.Design and synthesis of novel delta opioid receptor agonists and their pharmacologies. |
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