| Drug General Information |
| Drug ID |
D0O1JD
|
| Former ID |
DNC007801
|
| Drug Name |
6-(4-(2-(benzylamino)ethyl)phenoxy)nicotinamide
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C21H21N3O2
|
| Canonical SMILES |
C1=CC=C(C=C1)CNCCC2=CC=C(C=C2)OC3=NC=C(C=C3)C(=O)N
|
| InChI |
1S/C21H21N3O2/c22-21(25)18-8-11-20(24-15-18)26-19-9-6-16(7-10-19)12-13-23-14-17-4-2-1-3-5-17/h1-11,15,23H,12-14H2,(H2,22,25)
|
| InChIKey |
FCDWJNPFPYAKET-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Mu-type opioid receptor |
Target Info |
Inhibitor |
[1]
|
|---|
| Delta-type opioid receptor |
Target Info |
Inhibitor |
[1]
|
| Kappa-type opioid receptor |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
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Neuroactive ligand-receptor interaction
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Estrogen signaling pathway
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Morphine addictionhsa04022:cGMP-PKG signaling pathway
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Sphingolipid signaling pathway
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Neuroactive ligand-receptor interactionhsa04080:Neuroactive ligand-receptor interaction
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NetPath Pathway
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TCR Signaling Pathway
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PANTHER Pathway
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Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
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Enkephalin releaseP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Enkephalin release
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Opioid proenkephalin pathway
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Opioid proopiomelanocortin pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Opioid prodynorphin pathway
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Pathway Interaction Database
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IL4-mediated signaling events
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Reactome
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Peptide ligand-binding receptors
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G alpha (i) signalling eventsR-HSA-375276:Peptide ligand-binding receptors
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G alpha (i) signalling events
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WikiPathways
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TCR Signaling Pathway
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GPCRs, Class A Rhodopsin-like
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Peptide GPCRs
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Opioid Signalling
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GPCR ligand binding
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GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
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GPCR downstream signaling
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| References |
| REF 1 | Bioorg Med Chem Lett. 2007 Dec 15;17(24):6841-6. Epub 2007 Oct 17.Structure activity relationship studies of carboxamido-biaryl ethers as opioid receptor antagonists (OpRAs). Part 2. |
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